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Protein

Solute carrier family 12 member 9

Gene

Slc12a9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function (By similarity).By similarity

GO - Molecular functioni

  • potassium:chloride symporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 12 member 9
Alternative name(s):
Cation-chloride cotransporter-interacting protein 1
Potassium-chloride transporter 9
Gene namesi
Name:Slc12a9
Synonyms:Cip1, Slc12a8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1933532 Slc12a9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 72ExtracellularSequence analysisAdd BLAST15
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 119CytoplasmicSequence analysisAdd BLAST26
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 167ExtracellularSequence analysisAdd BLAST27
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 193CytoplasmicSequence analysis5
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 262ExtracellularSequence analysisAdd BLAST48
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 297CytoplasmicSequence analysisAdd BLAST14
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 338ExtracellularSequence analysisAdd BLAST20
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 376CytoplasmicSequence analysisAdd BLAST17
Transmembranei377 – 399HelicalSequence analysisAdd BLAST23
Topological domaini400 – 416ExtracellularSequence analysisAdd BLAST17
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 466CytoplasmicSequence analysisAdd BLAST29
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 740ExtracellularSequence analysisAdd BLAST253
Transmembranei741 – 761HelicalSequence analysisAdd BLAST21
Topological domaini762 – 914CytoplasmicSequence analysisAdd BLAST153

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314161 – 914Solute carrier family 12 member 9Add BLAST914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Glycosylationi228N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi243N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ99MR3
MaxQBiQ99MR3
PaxDbiQ99MR3
PeptideAtlasiQ99MR3
PRIDEiQ99MR3

PTM databases

iPTMnetiQ99MR3
PhosphoSitePlusiQ99MR3

Expressioni

Gene expression databases

BgeeiENSMUSG00000037344 Expressed in 265 organ(s), highest expression level in retina
ExpressionAtlasiQ99MR3 baseline and differential
GenevisibleiQ99MR3 MM

Interactioni

Subunit structurei

Interacts with SLC12A1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038106

Structurei

3D structure databases

ProteinModelPortaliQ99MR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi715 – 718Poly-Ser4
Compositional biasi811 – 816Poly-Glu6

Sequence similaritiesi

Belongs to the SLC12A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1288 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119053
HOGENOMiHOG000018183
HOVERGENiHBG106223
InParanoidiQ99MR3
KOiK14429
OMAiSNSMTVT
OrthoDBiEOG091G02RC
TreeFamiTF313191

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR018491 SLC12_C
IPR030345 SLC12A9
PANTHERiPTHR11827:SF52 PTHR11827:SF52, 1 hit
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PF03522 SLC12, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99MR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASESSPLLA YRLLGEEGAA FPPNGAGVSG VPSSRKLSTF LGVVVPTVLS
60 70 80 90 100
MFSIVVFLRI GFVVGHAGLL QALAMLLVAY IILALTVLSV CAIATNGAVR
110 120 130 140 150
GGGAYFMISR TLGPEVGGSI GLMFYLANVC GCAVSLLGLV ESILDVFGAD
160 170 180 190 200
ATGSSGIQVL PQGYGWNLLY GSLLLGLVGG VCTLGAGLYA RASFLTFLLV
210 220 230 240 250
SGSLASVLVS FVAVGPRNIP LAPRPGTNAS SVPHRHGHFT GFNGSTLRDN
260 270 280 290 300
LGAGYAEDYT TGAMMTFASV FAVLFNGCTG IMAGANMSGE LKDPSRAIPL
310 320 330 340 350
GTIIAVAYTF FIYILLFFLS SFTCDRALLQ EDYGFFRDIS LWPPLVLIGI
360 370 380 390 400
YATALSASMS SLIGASRILH ALAQDDLFGV ILAPAKVVSG GGNPWGAVLY
410 420 430 440 450
SWGLVQLVLL AGKLNTLAAV VTVFYLVAYA AVDLSCLSLE WASAPNFRPT
460 470 480 490 500
FSLFSWHTCL LGVASCLLMM FLISPGAAGG SLLLMGLLSA LLTARGGPSS
510 520 530 540 550
WGYVSQALLF HQVRKYLLRL DVRKEHVKFW RPQLLLLVGN PRGALPLLRL
560 570 580 590 600
ANQLKKGGLY VLGHVTLGDL DSLPSDPVQP QYGAWLSLVD LAQVKAFVDL
610 620 630 640 650
TLSPSVRQGA QHLLRISGLG GMKPNTLVLG FYDDAPPQDH FLTDPAFSEP
660 670 680 690 700
AEGTREGGSP ALSTLFPPPR APGSPRALSP QDYVATVADA LKMNKNVVLA
710 720 730 740 750
RACGALPPER LSRGSSSSAQ LHHVDVWPLN LLRPRGGPGY VDVCGLFLLQ
760 770 780 790 800
MATILSMVPA WHSARLRIFL CLGPREAPGA AEGRLRALLS QLRIRAEVQE
810 820 830 840 850
VVWGEGAETG EPEEEEGDFV NGGRGDEEAE ALACSANALV RAQQGRGTVG
860 870 880 890 900
GPGGPEGRDG EEGPTTALTF LYLPRPPADP ARYPRYLALL ETLSRDLGPT
910
LLIHGVTPVT CTDL
Length:914
Mass (Da):96,330
Last modified:July 27, 2011 - v2
Checksum:i769EA9EB4BD40E00
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z362D3Z362_MOUSE
Solute carrier family 12 member 9
Slc12a9
60Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34S → A in AAK28822 (PubMed:11239002).Curated1
Sequence conflicti34S → A in AAL26866 (Ref. 2) Curated1
Sequence conflicti34S → A in AAH46982 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312033 Genomic DNA Translation: AAK28822.1
AF314957 mRNA Translation: AAL26866.1
AC150682 Genomic DNA No translation available.
BC046982 mRNA Translation: AAH46982.1
CCDSiCCDS19766.1
RefSeqiNP_113583.2, NM_031406.3
XP_006504696.1, XM_006504633.3
UniGeneiMm.235625

Genome annotation databases

EnsembliENSMUST00000039991; ENSMUSP00000038106; ENSMUSG00000037344
GeneIDi83704
KEGGimmu:83704
UCSCiuc009ace.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312033 Genomic DNA Translation: AAK28822.1
AF314957 mRNA Translation: AAL26866.1
AC150682 Genomic DNA No translation available.
BC046982 mRNA Translation: AAH46982.1
CCDSiCCDS19766.1
RefSeqiNP_113583.2, NM_031406.3
XP_006504696.1, XM_006504633.3
UniGeneiMm.235625

3D structure databases

ProteinModelPortaliQ99MR3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038106

PTM databases

iPTMnetiQ99MR3
PhosphoSitePlusiQ99MR3

Proteomic databases

EPDiQ99MR3
MaxQBiQ99MR3
PaxDbiQ99MR3
PeptideAtlasiQ99MR3
PRIDEiQ99MR3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039991; ENSMUSP00000038106; ENSMUSG00000037344
GeneIDi83704
KEGGimmu:83704
UCSCiuc009ace.2 mouse

Organism-specific databases

CTDi56996
MGIiMGI:1933532 Slc12a9

Phylogenomic databases

eggNOGiKOG1288 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119053
HOGENOMiHOG000018183
HOVERGENiHBG106223
InParanoidiQ99MR3
KOiK14429
OMAiSNSMTVT
OrthoDBiEOG091G02RC
TreeFamiTF313191

Miscellaneous databases

PROiPR:Q99MR3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037344 Expressed in 265 organ(s), highest expression level in retina
ExpressionAtlasiQ99MR3 baseline and differential
GenevisibleiQ99MR3 MM

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR018491 SLC12_C
IPR030345 SLC12A9
PANTHERiPTHR11827:SF52 PTHR11827:SF52, 1 hit
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PF03522 SLC12, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS12A9_MOUSE
AccessioniPrimary (citable) accession number: Q99MR3
Secondary accession number(s): E9QNN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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