UniProtKB - Q99MR1 (GGYF1_MOUSE)
Protein
GRB10-interacting GYF protein 1
Gene
Gigyf1
Organism
Mus musculus (Mouse)
Status
Functioni
May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1.1 Publication
GO - Biological processi
Names & Taxonomyi
Protein namesi | Recommended name: GRB10-interacting GYF protein 1Alternative name(s): PERQ amino acid-rich with GYF domain-containing protein 1 |
Gene namesi | Name:Gigyf1 Synonyms:Kiaa4110, Perq1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1888677, Gigyf1 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 500 | W → A: Decreases binding to GRB10. 1 Publication | 1 | |
Mutagenesisi | 504 | G → A: Decreases binding to GRB10. 1 Publication | 1 | |
Mutagenesisi | 505 | Y → A: Decreases binding to GRB10. 1 Publication | 1 | |
Mutagenesisi | 506 | F → A: Abolishes binding to GRB10. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058315 | 1 – 1044 | GRB10-interacting GYF protein 1Add BLAST | 1044 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | PhosphoserineCombined sources | 1 | |
Modified residuei | 28 | PhosphoserineCombined sources | 1 | |
Modified residuei | 137 | PhosphoserineCombined sources | 1 | |
Modified residuei | 157 | PhosphoserineBy similarity | 1 | |
Modified residuei | 228 | PhosphoserineBy similarity | 1 | |
Modified residuei | 343 | PhosphoserineCombined sources | 1 | |
Modified residuei | 408 | PhosphoserineBy similarity | 1 | |
Modified residuei | 540 | PhosphoserineBy similarity | 1 | |
Modified residuei | 634 | PhosphoserineBy similarity | 1 | |
Modified residuei | 863 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q99MR1 |
jPOSTi | Q99MR1 |
MaxQBi | Q99MR1 |
PaxDbi | Q99MR1 |
PeptideAtlasi | Q99MR1 |
PRIDEi | Q99MR1 |
ProteomicsDBi | 268875 |
PTM databases
iPTMneti | Q99MR1 |
PhosphoSitePlusi | Q99MR1 |
Expressioni
Tissue specificityi
Ubiquitous. Lower expression in skeletal muscle, liver and testis.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000029714, Expressed in brain and 288 other tissues |
Genevisiblei | Q99MR1, MM |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 208260, 3 interactors |
IntActi | Q99MR1, 2 interactors |
MINTi | Q99MR1 |
STRINGi | 10090.ENSMUSP00000031727 |
Miscellaneous databases
RNActi | Q99MR1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 476 – 524 | GYFPROSITE-ProRule annotationAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 333 – 341 | Poly-Glu | 9 | |
Compositional biasi | 550 – 744 | Gln-richAdd BLAST | 195 | |
Compositional biasi | 601 – 604 | Poly-Gln | 4 | |
Compositional biasi | 694 – 697 | Poly-Glu | 4 | |
Compositional biasi | 707 – 712 | Poly-Gln | 6 | |
Compositional biasi | 720 – 723 | Poly-Glu | 4 | |
Compositional biasi | 741 – 744 | Poly-Gln | 4 | |
Compositional biasi | 884 – 887 | Poly-Glu | 4 | |
Compositional biasi | 970 – 984 | Poly-GlnAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the GIGYF family.Curated
Phylogenomic databases
eggNOGi | KOG1862, Eukaryota |
GeneTreei | ENSGT00940000159845 |
HOGENOMi | CLU_007300_0_0_1 |
InParanoidi | Q99MR1 |
OMAi | QYMMRRK |
OrthoDBi | 412069at2759 |
PhylomeDBi | Q99MR1 |
TreeFami | TF325513 |
Family and domain databases
CDDi | cd00072, GYF, 1 hit |
Gene3Di | 3.30.1490.40, 1 hit |
InterProi | View protein in InterPro IPR003169, GYF IPR035445, GYF-like_dom_sf |
Pfami | View protein in Pfam PF02213, GYF, 1 hit |
SMARTi | View protein in SMART SM00444, GYF, 1 hit |
SUPFAMi | SSF55277, SSF55277, 1 hit |
PROSITEi | View protein in PROSITE PS50829, GYF, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q99MR1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAETLNFGP EWLRALSSGG SVASPPPSPA MPKYKLADYR YGREEMLALY
60 70 80 90 100
VKENKVPEEL QDKEFAAVLQ EEPLQPLALE PLTEEEQRNF SLSVNSVAVL
110 120 130 140 150
RLMGKGAGPP LPATSRGRGS TRSRGRGRGD SCFYQRSIEE GDGAFGRNPR
160 170 180 190 200
EIQRSQSWDD RGERRFEKPA RRDGVRSGFE EGGAGPRKEH ARSDSENWRS
210 220 230 240 250
LREEQEDDGS WRLGAGPRRD GDRWRSTSPD GGPRSAGWRE HGERRRKFDF
260 270 280 290 300
DLRGERGGCG EEDGRVGGGN SHLRRCRGLD GFEDDKDGLP EWCLEDEDEE
310 320 330 340 350
MGTFDASGAF LPLKKGPKEA IPEEQELDFR GLEEEEEEEE EPSEGVDEER
360 370 380 390 400
PEAGGKEATP LPPPENSSSP SSLPALGPLW TTNEEGGEAV EKELPPAEGD
410 420 430 440 450
ELRGLSLSPR ISSPPGPPGD LEDEEGLKHL QQEAEKLVAS LQDSSLEEEQ
460 470 480 490 500
FTAAMQTQGL RHSTAATALP LSHGAARKWF YKDPQGEIQG PFTTQEMAEW
510 520 530 540 550
FQAGYFSMSL LVKRGCDEGF QPLGEVIKMW GRVPFAPGPS PPPLLGNMDQ
560 570 580 590 600
ERLKKQQELA AAALYQQLQH QHFLQLVGSR QLPQCTTLRE KAAMGDLTPP
610 620 630 640 650
QQQQLTTFLQ QLQALKTPRG GDQNLLPTMS RSLSVPDSGP LWDLHTSASS
660 670 680 690 700
QSGGEASLWD IPINSSTQGP ILEQLQLQHK FQERREVELR AKREEEERKR
710 720 730 740 750
REEKRRQQQQ QQEEQKRRQE EEELFRRKQV RQQELLLKLL QQQQATNVPV
760 770 780 790 800
PPAPSSPPPL WAGLAKQGLS MKTLLELQME SERQLHKQAA PREPLRAQAP
810 820 830 840 850
NHRVQLGGLG SAPLNQWVSE AGPLWGGPDK SGGSSGGNLG LWEDTLKSGG
860 870 880 890 900
SLARSLGLKS SRSSPSLSDS YSHLSGRPVR KKTEEEEKLL KLLQGIPRPQ
910 920 930 940 950
DGFTQWCEQM LHTLSTAGSL DVPMAVAILK EVESPYDVHD YIRSCLGDTL
960 970 980 990 1000
EAKEFAKQFL ERRAKQKASQ QRQQQQQQQQ QQQQEAWLSS TSLQTAFQAN
1010 1020 1030 1040
HSTKLGPGEG SKAKRRALML HSDPSILGYS LHGPSGEIES VDDY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JGR7 | A0A0G2JGR7_MOUSE | GRB10-interacting GYF protein 1 | Gigyf1 | 229 | Annotation score: |
Sequence cautioni
The sequence AAK28827 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 58 | Missing in AAO46886 (PubMed:12771153).Curated | 1 | |
Sequence conflicti | 275 | R → K in AAO46886 (PubMed:12771153).Curated | 1 | |
Sequence conflicti | 343 | S → A in AAO46886 (PubMed:12771153).Curated | 1 | |
Sequence conflicti | 404 | G → A in AAO46886 (PubMed:12771153).Curated | 1 | |
Sequence conflicti | 895 | G → S in AAK28827 (PubMed:11239002).Curated | 1 | |
Sequence conflicti | 973 – 975 | Missing in AAK28827 (PubMed:11239002).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF312033 Genomic DNA Translation: AAK28827.1 Sequence problems. AY176042 mRNA Translation: AAO46886.1 AK220289 mRNA Translation: BAD90214.1 |
CCDSi | CCDS51673.1 |
RefSeqi | NP_113596.2, NM_031408.2 XP_011239256.1, XM_011240954.1 |
Genome annotation databases
Ensembli | ENSMUST00000031727; ENSMUSP00000031727; ENSMUSG00000029714 |
GeneIDi | 57330 |
KEGGi | mmu:57330 |
UCSCi | uc009acp.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF312033 Genomic DNA Translation: AAK28827.1 Sequence problems. AY176042 mRNA Translation: AAO46886.1 AK220289 mRNA Translation: BAD90214.1 |
CCDSi | CCDS51673.1 |
RefSeqi | NP_113596.2, NM_031408.2 XP_011239256.1, XM_011240954.1 |
3D structure databases
SMRi | Q99MR1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 208260, 3 interactors |
IntActi | Q99MR1, 2 interactors |
MINTi | Q99MR1 |
STRINGi | 10090.ENSMUSP00000031727 |
PTM databases
iPTMneti | Q99MR1 |
PhosphoSitePlusi | Q99MR1 |
Proteomic databases
EPDi | Q99MR1 |
jPOSTi | Q99MR1 |
MaxQBi | Q99MR1 |
PaxDbi | Q99MR1 |
PeptideAtlasi | Q99MR1 |
PRIDEi | Q99MR1 |
ProteomicsDBi | 268875 |
Protocols and materials databases
Antibodypediai | 16628, 83 antibodies |
DNASUi | 57330 |
Genome annotation databases
Ensembli | ENSMUST00000031727; ENSMUSP00000031727; ENSMUSG00000029714 |
GeneIDi | 57330 |
KEGGi | mmu:57330 |
UCSCi | uc009acp.1, mouse |
Organism-specific databases
CTDi | 64599 |
MGIi | MGI:1888677, Gigyf1 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1862, Eukaryota |
GeneTreei | ENSGT00940000159845 |
HOGENOMi | CLU_007300_0_0_1 |
InParanoidi | Q99MR1 |
OMAi | QYMMRRK |
OrthoDBi | 412069at2759 |
PhylomeDBi | Q99MR1 |
TreeFami | TF325513 |
Miscellaneous databases
BioGRID-ORCSi | 57330, 6 hits in 52 CRISPR screens |
ChiTaRSi | Gigyf1, mouse |
PROi | PR:Q99MR1 |
RNActi | Q99MR1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029714, Expressed in brain and 288 other tissues |
Genevisiblei | Q99MR1, MM |
Family and domain databases
CDDi | cd00072, GYF, 1 hit |
Gene3Di | 3.30.1490.40, 1 hit |
InterProi | View protein in InterPro IPR003169, GYF IPR035445, GYF-like_dom_sf |
Pfami | View protein in Pfam PF02213, GYF, 1 hit |
SMARTi | View protein in SMART SM00444, GYF, 1 hit |
SUPFAMi | SSF55277, SSF55277, 1 hit |
PROSITEi | View protein in PROSITE PS50829, GYF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GGYF1_MOUSE | |
Accessioni | Q99MR1Primary (citable) accession number: Q99MR1 Secondary accession number(s): Q571A0, Q6Y7W9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | December 12, 2006 | |
Last modified: | April 7, 2021 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families