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UniProtKB - Q99MQ1 (BICC1_MOUSE)
Protein
Protein bicaudal C homolog 1
Gene
Bicc1
Organism
Mus musculus (Mouse)
Status
Functioni
Putative RNA-binding protein. May be involved in regulating gene expression during embryonic development.
GO - Molecular functioni
- RNA binding Source: MGI
GO - Biological processi
- determination of left/right symmetry Source: MGI
- heart development Source: MGI
- kidney development Source: MGI
- negative regulation of canonical Wnt signaling pathway Source: MGI
Keywordsi
Molecular function | Developmental protein, RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein bicaudal C homolog 1Short name: Bic-C |
Gene namesi | Name:Bicc1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1933388, Bicc1 |
VEuPathDBi | HostDB:ENSMUSG00000014329 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000267715 | 1 – 977 | Protein bicaudal C homolog 1Add BLAST | 977 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 27 | PhosphoserineCombined sources | 1 | |
Modified residuei | 32 | PhosphoserineCombined sources | 1 | |
Modified residuei | 45 | PhosphoserineCombined sources | 1 | |
Modified residuei | 400 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 614 | PhosphoserineCombined sources | 1 | |
Modified residuei | 681 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q99MQ1 |
MaxQBi | Q99MQ1 |
PaxDbi | Q99MQ1 |
PRIDEi | Q99MQ1 |
ProteomicsDBi | 273739 [Q99MQ1-1] 273740 [Q99MQ1-2] |
PTM databases
iPTMneti | Q99MQ1 |
PhosphoSitePlusi | Q99MQ1 |
Expressioni
Tissue specificityi
In the adult, predominantly expressed in heart and kidney. In 8 week old mice, expressed in growing primary oocytes and in the stromal cells of the theca.1 Publication
Developmental stagei
In the developing embryo, first detected at the rostral tip of the primitive streak, Hensen's node, at the late streak stage. At the late headfold stage, expression demarcates the layer of the node from which definitive endoderm and midline mesoderm arises. At 6-8 somite stage observed in the definitive endoderm. Strong expression is detected in the caudal intestinal portal. At 12-15 somite stage is still present in the hindgut, but transient expression is also seen in tissues of neural and mesodermal origins. At 13 dpc present around all sites of cartilage formation, such as cervical vertebral bodies, ribs and Merckel's cartilage. Additionally, expressed in the derivatives of the pleuroperitoneal membrane, the diaphragm and the pericardium, as well as the mesenchyme of the developing lung. Expressed in both the mesonephros and metanephros.
Gene expression databases
Bgeei | ENSMUSG00000014329, Expressed in dorsal pancreas and 285 other tissues |
Genevisiblei | Q99MQ1, MM |
Interactioni
Subunit structurei
Interacts (via KH domains) with ANKS6 (via SAM domain) in an RNA-dependent manner.
Interacts with ANKS3 (PubMed:25671767).
2 PublicationsProtein-protein interaction databases
CORUMi | Q99MQ1 |
STRINGi | 10090.ENSMUSP00000123201 |
Miscellaneous databases
RNActi | Q99MQ1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 134 – 201 | KH 1PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 286 – 350 | KH 2PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 875 – 938 | SAMPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 590 – 622 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 667 – 702 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 794 – 848 | DisorderedSequence analysisAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 27 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 590 – 621 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 794 – 811 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the BicC family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2208, Eukaryota KOG4374, Eukaryota |
GeneTreei | ENSGT00940000156276 |
HOGENOMi | CLU_008040_0_0_1 |
InParanoidi | Q99MQ1 |
OMAi | ATHIHFP |
OrthoDBi | 201055at2759 |
PhylomeDBi | Q99MQ1 |
TreeFami | TF323767 |
Family and domain databases
CDDi | cd09520, SAM_BICC1, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 3.30.1370.10, 1 hit |
InterProi | View protein in InterPro IPR037974, BICC1_SAM_dom IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR001660, SAM IPR013761, SAM/pointed_sf |
Pfami | View protein in Pfam PF00013, KH_1, 2 hits PF00536, SAM_1, 1 hit |
SMARTi | View protein in SMART SM00322, KH, 3 hits SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF54791, SSF54791, 3 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 2 hits PS50105, SAM_DOMAIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q99MQ1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASQSEPGYL AAAQSDPGSN SERSTDSPVA GSEDDLVAAA PLLHSPEWSE
60 70 80 90 100
ERFRVDRKKL EAMLQAAAEG KGRSGEDFFQ KIMEETNTQI AWPSKLKIGA
110 120 130 140 150
KSKKDPHIKV SGKKEDVKEA KEMIMSVLDT KSNRVTLKMD VSHTEHSHVI
160 170 180 190 200
GKGGNNIKKV MEDTGCHIHF PDSNRNNQAE KSNQVSIAGQ PAGVESARAR
210 220 230 240 250
IRELLPLVLM FELPIAGILQ PVPDPNTPSI QHISQTYSVS VSFKQRSRMY
260 270 280 290 300
GATVTVRGSQ NNTNAVKEGT AMLLEHLAGS LASAIPVSTQ LDIAAQHHLF
310 320 330 340 350
MMGRNGSNVK HIMQRTGAQI HFPDPSNPQK KSTVYLQGTI ESVCLARQYL
360 370 380 390 400
MGCLPLVLMF DMKEDIEVDP QVIAQLMEQL DVFISIKPKP KQPSKSVIVK
410 420 430 440 450
SVERNALNMY EARKCLLGLE SSGVSIATSL SPASCPAGLA CPSLDILASA
460 470 480 490 500
GLGLTGLGLL GPTTLSLNTS ATPNSLLNAL NTSVSPLQSS SSGTPSPTLW
510 520 530 540 550
APPIANTASA TGFSTIPHLM LPSTAQATLT NILLSGVPTY GHTAPSPPPG
560 570 580 590 600
LTPVDVHINS MQTEGKNISA SINGHVQPAN MKYGPLSTSS LGEKVLSSNH
610 620 630 640 650
GDPSMQTAGP EQASPKSNSV EGCNDAFVEV GMPRSPSHSG NAGDLKQMLG
660 670 680 690 700
ASKVSCAKRQ TVELLQGTKN SHLHGTDRLL SDPELSATES PLADKKAPGS
710 720 730 740 750
ERAAERAAAA QQKSERARLA SQPTYVHMQA FDYEQKKLLA TKAMLKKPVV
760 770 780 790 800
TEVRTPTNTW SGLGFSKSMP AETIKELRRA NHVSYKPTMT TAYEGSSLSL
810 820 830 840 850
SRSSSREHLA SGSESDNWRD RNGIGPMGHS EFSAPIGSPK RKQNKSREHY
860 870 880 890 900
LSSSNYMDCI SSLTGSNGCN LNSCFKGSDL PELFSKLGLG KYTDVFQQQE
910 920 930 940 950
IDLQTFLTLT DQDLKELGIT TFGARRKMLL AISELSKNRR KLFEPPNASC
960 970
TSFLEGGASG RLPRQYHSDI ASVSGRW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3X8S6 | G3X8S6_MOUSE | Protein bicaudal C homolog 1 | Bicc1 | 951 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 276 | H → R in BAC40732 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021950 | 1 – 82 | Missing in isoform 2. 1 PublicationAdd BLAST | 82 | |
Alternative sequenceiVSP_021951 | 934 – 977 | ELSKN…VSGRW → VCDSVQIRNKILRAARIL in isoform 2. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF319464 mRNA Translation: AAK27347.1 AK089066 mRNA Translation: BAC40732.1 BC062174 mRNA Translation: AAH62174.1 BC111523 mRNA Translation: AAI11524.1 |
CCDSi | CCDS23915.1 [Q99MQ1-1] |
RefSeqi | NP_113574.1, NM_031397.3 [Q99MQ1-1] |
Genome annotation databases
Ensembli | ENSMUST00000131445; ENSMUSP00000119137; ENSMUSG00000014329 [Q99MQ1-2] ENSMUST00000143791; ENSMUSP00000123201; ENSMUSG00000014329 [Q99MQ1-1] |
GeneIDi | 83675 |
KEGGi | mmu:83675 |
UCSCi | uc007fog.2, mouse [Q99MQ1-1] uc033fpy.1, mouse [Q99MQ1-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF319464 mRNA Translation: AAK27347.1 AK089066 mRNA Translation: BAC40732.1 BC062174 mRNA Translation: AAH62174.1 BC111523 mRNA Translation: AAI11524.1 |
CCDSi | CCDS23915.1 [Q99MQ1-1] |
RefSeqi | NP_113574.1, NM_031397.3 [Q99MQ1-1] |
3D structure databases
AlphaFoldDBi | Q99MQ1 |
SMRi | Q99MQ1 |
ModBasei | Search... |
Protein-protein interaction databases
CORUMi | Q99MQ1 |
STRINGi | 10090.ENSMUSP00000123201 |
PTM databases
iPTMneti | Q99MQ1 |
PhosphoSitePlusi | Q99MQ1 |
Proteomic databases
jPOSTi | Q99MQ1 |
MaxQBi | Q99MQ1 |
PaxDbi | Q99MQ1 |
PRIDEi | Q99MQ1 |
ProteomicsDBi | 273739 [Q99MQ1-1] 273740 [Q99MQ1-2] |
Protocols and materials databases
Antibodypediai | 51885, 165 antibodies from 26 providers |
DNASUi | 83675 |
Genome annotation databases
Ensembli | ENSMUST00000131445; ENSMUSP00000119137; ENSMUSG00000014329 [Q99MQ1-2] ENSMUST00000143791; ENSMUSP00000123201; ENSMUSG00000014329 [Q99MQ1-1] |
GeneIDi | 83675 |
KEGGi | mmu:83675 |
UCSCi | uc007fog.2, mouse [Q99MQ1-1] uc033fpy.1, mouse [Q99MQ1-2] |
Organism-specific databases
CTDi | 80114 |
MGIi | MGI:1933388, Bicc1 |
VEuPathDBi | HostDB:ENSMUSG00000014329 |
Phylogenomic databases
eggNOGi | KOG2208, Eukaryota KOG4374, Eukaryota |
GeneTreei | ENSGT00940000156276 |
HOGENOMi | CLU_008040_0_0_1 |
InParanoidi | Q99MQ1 |
OMAi | ATHIHFP |
OrthoDBi | 201055at2759 |
PhylomeDBi | Q99MQ1 |
TreeFami | TF323767 |
Miscellaneous databases
BioGRID-ORCSi | 83675, 0 hits in 71 CRISPR screens |
ChiTaRSi | Bicc1, mouse |
PROi | PR:Q99MQ1 |
RNActi | Q99MQ1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000014329, Expressed in dorsal pancreas and 285 other tissues |
Genevisiblei | Q99MQ1, MM |
Family and domain databases
CDDi | cd09520, SAM_BICC1, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 3.30.1370.10, 1 hit |
InterProi | View protein in InterPro IPR037974, BICC1_SAM_dom IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR001660, SAM IPR013761, SAM/pointed_sf |
Pfami | View protein in Pfam PF00013, KH_1, 2 hits PF00536, SAM_1, 1 hit |
SMARTi | View protein in SMART SM00322, KH, 3 hits SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF54791, SSF54791, 3 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 2 hits PS50105, SAM_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BICC1_MOUSE | |
Accessioni | Q99MQ1Primary (citable) accession number: Q99MQ1 Secondary accession number(s): Q6P6K3, Q8C286 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families