Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Propionyl-CoA carboxylase beta chain, mitochondrial

Gene

Pccb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

Pathwayi: propanoyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Propionyl-CoA carboxylase alpha chain, mitochondrial (Pcca), Propionyl-CoA carboxylase beta chain, mitochondrial (Pccb)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • CoA carboxylase activity Source: GO_Central
  • propionyl-CoA carboxylase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.4.1.3 3474
ReactomeiR-MMU-196780 Biotin transport and metabolism
R-MMU-71032 Propionyl-CoA catabolism
UniPathwayiUPA00945; UER00908

Names & Taxonomyi

Protein namesi
Recommended name:
Propionyl-CoA carboxylase beta chain, mitochondrial (EC:6.4.1.3)
Short name:
PCCase subunit beta
Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase subunit beta
Gene namesi
Name:Pccb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914154 Pccb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionBy similarityAdd BLAST28
ChainiPRO_000000029429 – 541Propionyl-CoA carboxylase beta chain, mitochondrialAdd BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineBy similarity1
Modified residuei101N6-acetyllysine; alternateCombined sources1
Modified residuei101N6-succinyllysine; alternateCombined sources1
Modified residuei250N6-succinyllysineCombined sources1
Modified residuei476N6-acetyllysine; alternateCombined sources1
Modified residuei476N6-succinyllysine; alternateCombined sources1
Modified residuei491N6-acetyllysine; alternateCombined sources1
Modified residuei491N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99MN9
MaxQBiQ99MN9
PaxDbiQ99MN9
PeptideAtlasiQ99MN9
PRIDEiQ99MN9

2D gel databases

REPRODUCTION-2DPAGEiQ99MN9

PTM databases

iPTMnetiQ99MN9
PhosphoSitePlusiQ99MN9
SwissPalmiQ99MN9

Expressioni

Tissue specificityi

Broadly expressed. Most abundantly expressed in the kidney, liver, small intestine and stomach.1 Publication

Gene expression databases

BgeeiENSMUSG00000032527
ExpressionAtlasiQ99MN9 baseline and differential
GenevisibleiQ99MN9 MM

Interactioni

Subunit structurei

Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.By similarity

Protein-protein interaction databases

IntActiQ99MN9, 3 interactors
MINTiQ99MN9
STRINGi10090.ENSMUSP00000035116

Structurei

3D structure databases

ProteinModelPortaliQ99MN9
SMRiQ99MN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 292CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST259
Domaini296 – 535CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 535CarboxyltransferasePROSITE-ProRule annotationAdd BLAST502
Regioni327 – 360Acyl-CoA bindingSequence analysisAdd BLAST34

Sequence similaritiesi

Belongs to the AccD/PCCB family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0540 Eukaryota
COG4799 LUCA
GeneTreeiENSGT00530000063337
HOGENOMiHOG000218693
HOVERGENiHBG003970
InParanoidiQ99MN9
KOiK01966
OMAiGKLWVRE
OrthoDBiEOG091G04S4
TreeFamiTF314350

Family and domain databases

InterProiView protein in InterPro
IPR034733 AcCoA_carboxyl
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
IPR011762 COA_CT_N
PfamiView protein in Pfam
PF01039 Carboxyl_trans, 1 hit
SUPFAMiSSF52096 SSF52096, 2 hits
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit
PS50980 COA_CT_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99MN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAIRIRAV AAGARLSVLN CGLGITTRGL CSQPVSVKER IDNKRHAALL
60 70 80 90 100
GGGQRRIDAQ HKRGKLTARE RISLLLDPGS FMESDMFVEH RCADFGMAAD
110 120 130 140 150
KNKFPGDSVV TGRGRINGRL VYVFSQDFTV FGGSLSGAHA QKICKIMDQA
160 170 180 190 200
ITVGAPVIGL NDSGGARIQE GVESLAGYAD IFLRNVTASG VIPQISLIMG
210 220 230 240 250
PCAGGAVYSP ALTDFTFMVK DTSYLFITGP EVVKSVTNED VTQEQLGGAK
260 270 280 290 300
THTTVSGVAH RAFDNDVDAL CNLREFFNFL PLSSQDPAPI RECHDPSDRL
310 320 330 340 350
VPELDTVVPL ESSKAYNMLD IIHAVIDERE FFEIMPSYAK NIVVGFARMN
360 370 380 390 400
GRTVGIVGNQ PNVASGCLDI NSSVKGARFV RFCDAFNIPL ITFVDVPGFL
410 420 430 440 450
PGTAQEYGGI IRHGAKLLYA FAEATVPKIT VITRKAYGGA YDVMSSKHLL
460 470 480 490 500
GDTNYAWPTA EIAVMGAKGA VEIIFKGHQD VEAAQAEYVE KFANPFPAAV
510 520 530 540
RGFVDDIIQP SSTRARICCD LEVLASKKVH RPWRKHANIP L
Length:541
Mass (Da):58,409
Last modified:July 27, 2011 - v2
Checksum:i1DFB5978BD81103B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti340K → L in AAK28525 (PubMed:11245989).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327060 mRNA Translation: AAK28525.1
AK004976 mRNA Translation: BAB23712.1
AK050366 mRNA Translation: BAC34211.1
CCDSiCCDS23442.1
RefSeqiNP_001298078.1, NM_001311149.1
NP_080111.1, NM_025835.3
UniGeneiMm.335385

Genome annotation databases

EnsembliENSMUST00000035116; ENSMUSP00000035116; ENSMUSG00000032527
GeneIDi66904
KEGGimmu:66904
UCSCiuc009rfc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPCCB_MOUSE
AccessioniPrimary (citable) accession number: Q99MN9
Secondary accession number(s): Q9DBG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health