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Protein

Urocortin-2

Gene

Ucn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity).By similarity

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 2 binding Source: MGI
  • corticotropin-releasing hormone receptor binding Source: UniProtKB
  • G protein-coupled receptor binding Source: MGI
  • hormone activity Source: UniProtKB-KW
  • hormone binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-2
Alternative name(s):
Urocortin II
Short name:
Ucn II
Gene namesi
Name:Ucn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2176375 Ucn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
PropeptideiPRO_000000624124 – 711 PublicationAdd BLAST48
ChainiPRO_000000624273 – 110Urocortin-2Add BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110Valine amide; partial1 Publication1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Amidation, Glycoprotein

Proteomic databases

PaxDbiQ99ML8
PRIDEiQ99ML8

Expressioni

Gene expression databases

BgeeiENSMUSG00000049699 Expressed in 38 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_UCN2
GenevisibleiQ99ML8 MM

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228607, 2 interactors
STRINGi10090.ENSMUSP00000060405

Structurei

3D structure databases

ProteinModelPortaliQ99ML8
SMRiQ99ML8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5CP Eukaryota
ENOG4111C21 LUCA
GeneTreeiENSGT00390000004650
HOGENOMiHOG000154768
HOVERGENiHBG036242
InParanoidiQ99ML8
KOiK05257
OMAiMTRCALL
OrthoDBiEOG091G171N
TreeFamiTF330723

Family and domain databases

InterProiView protein in InterPro
IPR000187 CRF
IPR024273 Urocortin_II
IPR024270 Urocortin_II/III
PANTHERiPTHR17575 PTHR17575, 1 hit
PTHR17575:SF0 PTHR17575:SF0, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD455741 PD455741, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99ML8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMTRWALVVF VVLMLDRILF VPGTPIPTFQ LLPQNSLETT PSSVTSESSS
60 70 80 90 100
GTTTGPSASW SNSKASPYLD TRVILSLDVP IGLLRILLEQ ARYKAARNQA
110
ATNAQILAHV GRR
Length:113
Mass (Da):12,310
Last modified:September 18, 2013 - v2
Checksum:i9C55EB416C7D5B25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140383 Genomic DNA No translation available.
AF331517 mRNA Translation: AAK16157.1
CCDSiCCDS52929.1
RefSeqiNP_659543.1, NM_145077.1
UniGeneiMm.388865

Genome annotation databases

EnsembliENSMUST00000052724; ENSMUSP00000060405; ENSMUSG00000049699
GeneIDi171530
KEGGimmu:171530
UCSCiuc012hax.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140383 Genomic DNA No translation available.
AF331517 mRNA Translation: AAK16157.1
CCDSiCCDS52929.1
RefSeqiNP_659543.1, NM_145077.1
UniGeneiMm.388865

3D structure databases

ProteinModelPortaliQ99ML8
SMRiQ99ML8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228607, 2 interactors
STRINGi10090.ENSMUSP00000060405

Proteomic databases

PaxDbiQ99ML8
PRIDEiQ99ML8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052724; ENSMUSP00000060405; ENSMUSG00000049699
GeneIDi171530
KEGGimmu:171530
UCSCiuc012hax.1 mouse

Organism-specific databases

CTDi90226
MGIiMGI:2176375 Ucn2

Phylogenomic databases

eggNOGiENOG410J5CP Eukaryota
ENOG4111C21 LUCA
GeneTreeiENSGT00390000004650
HOGENOMiHOG000154768
HOVERGENiHBG036242
InParanoidiQ99ML8
KOiK05257
OMAiMTRCALL
OrthoDBiEOG091G171N
TreeFamiTF330723

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)

Miscellaneous databases

PROiPR:Q99ML8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049699 Expressed in 38 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_UCN2
GenevisibleiQ99ML8 MM

Family and domain databases

InterProiView protein in InterPro
IPR000187 CRF
IPR024273 Urocortin_II
IPR024270 Urocortin_II/III
PANTHERiPTHR17575 PTHR17575, 1 hit
PTHR17575:SF0 PTHR17575:SF0, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD455741 PD455741, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUCN2_MOUSE
AccessioniPrimary (citable) accession number: Q99ML8
Secondary accession number(s): F8WIL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: September 18, 2013
Last modified: November 7, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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