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Protein

Bcl-2-binding component 3

Gene

Bbc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53 (By similarity). Regulates ER stress-induced neuronal apoptosis.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-binding component 3
Alternative name(s):
p53 up-regulated modulator of apoptosis
Gene namesi
Name:Bbc3
Synonyms:Puma
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2181667 Bbc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430841 – 193Bcl-2-binding component 3Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99ML1
MaxQBiQ99ML1
PaxDbiQ99ML1
PRIDEiQ99ML1

PTM databases

iPTMnetiQ99ML1
PhosphoSitePlusiQ99ML1

Expressioni

Inductioni

By DNA damage, glucocorticoid treatment, growth factor deprivation and p53 (By similarity). By ER stress in a DDIT3/CHOP-dependent manner.By similarity1 Publication

Gene expression databases

BgeeiENSMUSG00000002083 Expressed in 212 organ(s), highest expression level in blood
CleanExiMM_BBC3
ExpressionAtlasiQ99ML1 baseline and differential
GenevisibleiQ99ML1 MM

Interactioni

Subunit structurei

Interacts with MCL1 and BCL2A1 (PubMed:18589438, PubMed:18462686). Interacts with BCL2 and BCL2L1/BCL-XL (By similarity). Interacts (via BH3 domain) with NOL3 (via CARD domain); this interaction prevents BBC3 association with BCL2 and results in CASP8 activation (By similarity).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228430, 1 interactor
ComplexPortaliCPX-2027 PUMA:BCL-2 complex
CPX-2029 PUMA:BCL-XL complex
CORUMiQ99ML1
DIPiDIP-29805N
ELMiQ99ML1
IntActiQ99ML1, 3 interactors
STRINGi10090.ENSMUSP00000002152

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99ML1
SMRiQ99ML1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99ML1

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi137 – 151BH3Add BLAST15

Domaini

The BH3 motif is intrinsically disordered.By similarity

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiENOG410IW36 Eukaryota
ENOG41119TR LUCA
GeneTreeiENSGT00390000002767
HOGENOMiHOG000060256
HOVERGENiHBG050671
InParanoidiQ99ML1
KOiK10132
OMAiGPRPDXR
OrthoDBiEOG091G0VPS
PhylomeDBiQ99ML1
TreeFamiTF338776

Family and domain databases

InterProiView protein in InterPro
IPR031661 Bbc3
PANTHERiPTHR28639 PTHR28639, 1 hit
PfamiView protein in Pfam
PF15826 PUMA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99ML1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARARQEGSS PEPVEGLARD SPRPFPLGRL MPSAVSCSLC EPGLPAAPAA
60 70 80 90 100
PALLPAAYLC APTAPPAVTA ALGGPRWPGG HRSRPRGPRP DGPQPSLSPA
110 120 130 140 150
QQHLESPVPS APEALAGGPT QAAPGVRVEE EEWAREIGAQ LRRMADDLNA
160 170 180 190
QYERRRQEEQ HRHRPSPWRV MYNLFMGLLP LPRDPGAPEM EPN
Length:193
Mass (Da):20,749
Last modified:June 1, 2001 - v1
Checksum:i39A98487FA86D226
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2M5D3Z2M5_MOUSE
Bcl-2-binding component 3
Bbc3
128Annotation score:
A0A1B0GR88A0A1B0GR88_MOUSE
Bcl-2-binding component 3
Bbc3
91Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332560 mRNA Translation: AAK31317.1
BC044782 mRNA Translation: AAH44782.1
BC060370 mRNA Translation: AAH60370.1
CCDSiCCDS20847.1
RefSeqiNP_573497.1, NM_133234.2
XP_006539640.1, XM_006539577.3
XP_006539641.1, XM_006539578.3
XP_006539642.1, XM_006539579.3
XP_006539643.1, XM_006539580.2
XP_006539644.1, XM_006539581.1
XP_006539645.1, XM_006539582.2
UniGeneiMm.7660

Genome annotation databases

EnsembliENSMUST00000002152; ENSMUSP00000002152; ENSMUSG00000002083
GeneIDi170770
KEGGimmu:170770
UCSCiuc009fho.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332560 mRNA Translation: AAK31317.1
BC044782 mRNA Translation: AAH44782.1
BC060370 mRNA Translation: AAH60370.1
CCDSiCCDS20847.1
RefSeqiNP_573497.1, NM_133234.2
XP_006539640.1, XM_006539577.3
XP_006539641.1, XM_006539578.3
XP_006539642.1, XM_006539579.3
XP_006539643.1, XM_006539580.2
XP_006539644.1, XM_006539581.1
XP_006539645.1, XM_006539582.2
UniGeneiMm.7660

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ROCNMR-B130-155[»]
2VOFX-ray1.80B/D130-155[»]
ProteinModelPortaliQ99ML1
SMRiQ99ML1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228430, 1 interactor
ComplexPortaliCPX-2027 PUMA:BCL-2 complex
CPX-2029 PUMA:BCL-XL complex
CORUMiQ99ML1
DIPiDIP-29805N
ELMiQ99ML1
IntActiQ99ML1, 3 interactors
STRINGi10090.ENSMUSP00000002152

PTM databases

iPTMnetiQ99ML1
PhosphoSitePlusiQ99ML1

Proteomic databases

EPDiQ99ML1
MaxQBiQ99ML1
PaxDbiQ99ML1
PRIDEiQ99ML1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002152; ENSMUSP00000002152; ENSMUSG00000002083
GeneIDi170770
KEGGimmu:170770
UCSCiuc009fho.2 mouse

Organism-specific databases

CTDi27113
MGIiMGI:2181667 Bbc3

Phylogenomic databases

eggNOGiENOG410IW36 Eukaryota
ENOG41119TR LUCA
GeneTreeiENSGT00390000002767
HOGENOMiHOG000060256
HOVERGENiHBG050671
InParanoidiQ99ML1
KOiK10132
OMAiGPRPDXR
OrthoDBiEOG091G0VPS
PhylomeDBiQ99ML1
TreeFamiTF338776

Miscellaneous databases

EvolutionaryTraceiQ99ML1
PROiPR:Q99ML1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002083 Expressed in 212 organ(s), highest expression level in blood
CleanExiMM_BBC3
ExpressionAtlasiQ99ML1 baseline and differential
GenevisibleiQ99ML1 MM

Family and domain databases

InterProiView protein in InterPro
IPR031661 Bbc3
PANTHERiPTHR28639 PTHR28639, 1 hit
PfamiView protein in Pfam
PF15826 PUMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBBC3_MOUSE
AccessioniPrimary (citable) accession number: Q99ML1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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