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Protein

Zinc finger MYND domain-containing protein 10

Gene

Zmynd10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in axonemal structure organization and motility (PubMed:29601588). Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (PubMed:29601588). May act by indirectly regulating transcription of dynein proteins (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri394 – 430MYND-typePROSITE-ProRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

  • inner dynein arm assembly Source: UniProtKB
  • motile cilium assembly Source: UniProtKB
  • outer dynein arm assembly Source: UniProtKB
  • positive regulation of motile cilium assembly Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYND domain-containing protein 10
Alternative name(s):
Protein BLu
Gene namesi
Name:Zmynd10
Synonyms:Blu
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2387863 Zmynd10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice neonates exhibit growth retardation dying within 1 month after birth. Show head deformation and situs invertus (heart apex, stomach, liver or spleen). Display lung lobular structures deterioration and collapsed alveolar spaces. Show mucosal congestion in paranasal cavities. Show loss of ciliary motility and axonemal outer and inner dynein arm (IDA and ODA, respectively) components without disruption of ciliogenesis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002183151 – 440Zinc finger MYND domain-containing protein 10Add BLAST440

Proteomic databases

MaxQBiQ99ML0
PaxDbiQ99ML0
PRIDEiQ99ML0

PTM databases

iPTMnetiQ99ML0
PhosphoSitePlusiQ99ML0

Expressioni

Tissue specificityi

Expressed in the testis. Expressed in the tracheal epithelium (PubMed:29601588). Restricted to regions containing motile cilia (PubMed:23891471).2 Publications

Developmental stagei

Specifically expressed in the ciliated epithelial layer associated with nasal and lung epithelium in E18.5 embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000010044 Expressed in 66 organ(s), highest expression level in testis
CleanExiMM_ZMYND10
ExpressionAtlasiQ99ML0 baseline and differential
GenevisibleiQ99ML0 MM

Interactioni

Subunit structurei

Interacts (via C-terminus) with LRRC6 (via CS domain); this interaction stabilizes LRRC6 at the protein level. Interacts (via C-terminus) with DNAL1; this interaction stabilizes DNAL1 at the protein level. Interacts with DNAAF4, HSPA8, IQUB, RUVBL2 and TCTEX1D1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000010188

Structurei

3D structure databases

ProteinModelPortaliQ99ML0
SMRiQ99ML0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZMYND10 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri394 – 430MYND-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIFT Eukaryota
ENOG410Z083 LUCA
GeneTreeiENSGT00390000010195
HOGENOMiHOG000007333
HOVERGENiHBG055814
InParanoidiQ99ML0
OMAiIYKIGLR
OrthoDBiEOG091G0759
TreeFamiTF324215

Family and domain databases

InterProiView protein in InterPro
IPR017333 UCP037948_Znf-MYND
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF01753 zf-MYND, 1 hit
PIRSFiPIRSF037948 UCP037948_Znf_MYND10, 1 hit
PROSITEiView protein in PROSITE
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99ML0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDLELLLPG EAEVLVRGLR SFQLREMGSE GWNKQHESLE KLNMQAILDA
60 70 80 90 100
TISQAEPIQE LLINHGKIPT LVEELIAVEM WKQKVFPVLC RLEDFKPQNT
110 120 130 140 150
FPIYMVVHHE ASIINLLETV FFHKEVCESA DDKVLDLVDY CHRKLILLVA
160 170 180 190 200
RKGGGDLSEE EQFQDSTPMQ ELQKQAEMME FEISLKALSV LRYITDCVDS
210 220 230 240 250
LSLSTLNRML RTHNLPCLLV ELLEHSPWSR RVGGKLQHFE SGRWQTVAPS
260 270 280 290 300
EQQKLNKLDG QVWIALYNLL LSPEARARYC LTSFAKGQLL KLQAFLTDTL
310 320 330 340 350
LDQLPNLADL KGFLAHLSLA ETQPPKKDLV LEQIPEIWDR LERENKGKWQ
360 370 380 390 400
AIAKHQLQHV FSLSEKDLRQ QAQRWAETYR LDVLEAVAPE RPRCGYCNAE
410 420 430 440
ASKRCSRCQN VWYCCRECQV KHWEKHGKTC VLAAQGDRAK
Length:440
Mass (Da):50,646
Last modified:July 27, 2011 - v2
Checksum:iA9449F82B3050CEA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YW68A0A0A6YW68_MOUSE
Zinc finger MYND domain-containing ...
Zmynd10
41Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63I → V in AAK21199 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333027 Genomic DNA Translation: AAK21199.1
AK132332 mRNA Translation: BAE21110.1
CH466560 Genomic DNA Translation: EDL21195.1
BC052357 mRNA Translation: AAH52357.1
CCDSiCCDS23493.1
RefSeqiNP_444483.2, NM_053253.3
UniGeneiMm.28331

Genome annotation databases

EnsembliENSMUST00000010188; ENSMUSP00000010188; ENSMUSG00000010044
GeneIDi114602
KEGGimmu:114602
UCSCiuc009rlo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333027 Genomic DNA Translation: AAK21199.1
AK132332 mRNA Translation: BAE21110.1
CH466560 Genomic DNA Translation: EDL21195.1
BC052357 mRNA Translation: AAH52357.1
CCDSiCCDS23493.1
RefSeqiNP_444483.2, NM_053253.3
UniGeneiMm.28331

3D structure databases

ProteinModelPortaliQ99ML0
SMRiQ99ML0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000010188

PTM databases

iPTMnetiQ99ML0
PhosphoSitePlusiQ99ML0

Proteomic databases

MaxQBiQ99ML0
PaxDbiQ99ML0
PRIDEiQ99ML0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010188; ENSMUSP00000010188; ENSMUSG00000010044
GeneIDi114602
KEGGimmu:114602
UCSCiuc009rlo.1 mouse

Organism-specific databases

CTDi51364
MGIiMGI:2387863 Zmynd10

Phylogenomic databases

eggNOGiENOG410IIFT Eukaryota
ENOG410Z083 LUCA
GeneTreeiENSGT00390000010195
HOGENOMiHOG000007333
HOVERGENiHBG055814
InParanoidiQ99ML0
OMAiIYKIGLR
OrthoDBiEOG091G0759
TreeFamiTF324215

Miscellaneous databases

PROiPR:Q99ML0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010044 Expressed in 66 organ(s), highest expression level in testis
CleanExiMM_ZMYND10
ExpressionAtlasiQ99ML0 baseline and differential
GenevisibleiQ99ML0 MM

Family and domain databases

InterProiView protein in InterPro
IPR017333 UCP037948_Znf-MYND
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF01753 zf-MYND, 1 hit
PIRSFiPIRSF037948 UCP037948_Znf_MYND10, 1 hit
PROSITEiView protein in PROSITE
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZMY10_MOUSE
AccessioniPrimary (citable) accession number: Q99ML0
Secondary accession number(s): Q3V1P0, Q80W73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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