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Entry version 149 (12 Aug 2020)
Sequence version 1 (01 Jun 2001)
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Protein

ELKS/Rab6-interacting/CAST family member 1

Gene

Erc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ELKS/Rab6-interacting/CAST family member 1Curated
Short name:
ERC-1
Alternative name(s):
CAZ-associated structural protein 21 Publication
Short name:
CAST21 Publication
Rab6-interacting protein 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Erc1Imported
Synonyms:Cast21 Publication, Kiaa1081, Rab6ip21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:2151013, Erc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000971771 – 1120ELKS/Rab6-interacting/CAST family member 1Add BLAST1120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10N6-acetyllysineCombined sources1
Modified residuei17PhosphoserineBy similarity1
Modified residuei21PhosphoserineCombined sources1
Modified residuei37PhosphoserineBy similarity1
Modified residuei38PhosphothreonineBy similarity1
Modified residuei55PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei94PhosphoserineBy similarity1
Modified residuei824PhosphoserineCombined sources1
Modified residuei1009PhosphoserineBy similarity1
Modified residuei1050PhosphothreonineBy similarity1
Isoform 2 (identifier: Q99MI1-2)
Modified residuei965PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99MI1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99MI1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99MI1

PeptideAtlas

More...
PeptideAtlasi
Q99MI1

PRoteomics IDEntifications database

More...
PRIDEi
Q99MI1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99MI1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99MI1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030172, Expressed in undifferentiated genital tubercle and 272 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99MI1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99MI1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the GTB-bound forms of RAB6A isoform 1 and isoform 2 and with RAB6B. The interaction was strongest with RAB6B, followed by RAB6A isoform 2 and weakest with RAB6A isoform 1.

Part of a complex with CHUK, IKBKB and IKBKG.

Interacts with CHUK, IKBKB and IKBKG. The interaction with IKBKG is independent of CHUK and IKBKB.

Interacts with NFKBIA (By similarity). Isoform 2 interacts through its C-terminus with the PDZ domains of RIMS1 and RIMS2.

Interacts with ERC2/CAST1 (By similarity).

Interacts with SDCCAG8.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
226265, 11 interactors

Protein interaction database and analysis system

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IntActi
Q99MI1, 11 interactors

Molecular INTeraction database

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MINTi
Q99MI1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000078534

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99MI1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1050 – 1112FIP-RBDPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili144 – 992Sequence analysisAdd BLAST849
Coiled coili1060 – 1104Sequence analysisAdd BLAST45

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4809, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00650000093320

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_815229_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99MI1

KEGG Orthology (KO)

More...
KOi
K16072

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99MI1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019323, ELKS/CAST
IPR037245, FIP-RBD_C_sf
IPR019018, Rab-bd_FIP-RBD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10174, Cast, 3 hits
PF09457, RBD-FIP, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF144270, SSF144270, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51511, FIP_RBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99MI1-1) [UniParc]FASTAAdd to basket
Also known as: B, beta

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGNSVGGGS
60 70 80 90 100
GKTLSMENIQ SLNAAYATSG PMYLSDHENV GAETPKSTMT LGRSGGRLPY
110 120 130 140 150
GVRMTAMGSS PNIASSGVAS DTIAFGEHHL PPVSMASTVP HSLRQARDNT
160 170 180 190 200
IMDLQTQLKE VLRENDLLRK DVEVKESKLS SSMNSIKTFW SPELKKERAL
210 220 230 240 250
RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR DLNQLFQQDS
260 270 280 290 300
SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ
310 320 330 340 350
TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL
360 370 380 390 400
EQKEKENNML REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD
410 420 430 440 450
LEEEIQMLKS NGALSSEERE EEMKQMEVYR SHSKFMKNKV EQLKEELSSK
460 470 480 490 500
DAQGEELKKR AAGLQSEIGQ VKQELSRKDT ELLALQTKLE TLTNQFSDSK
510 520 530 540 550
QHIEVLKESL TAKEQRAAIL QTEVDALRLR LEEKETMLNK KTKQIQDMAE
560 570 580 590 600
EKGTQAGEIH DLKDMLDVKE RKVNVLQKKI ENLQEQLRDK EKQMSSLKER
610 620 630 640 650
VKSLQADTTN TDTALTTLEE ALADKERTIE RLKEQRDRDE REKQEEIDTY
660 670 680 690 700
KKDLKDLREK VSLLQGDLSE KEASLLDIKE HASSLASSGL KKDSRLKTLE
710 720 730 740 750
IALEQKKEEC LKMESQLKKA HEATLEARAS PEMSDRIQQL EREISRYKDE
760 770 780 790 800
SSKAQTEVDR LLEILKEVEN EKNDKDKKIA ELESLTSRQV KDQNKKVANL
810 820 830 840 850
KHKEQVEKKK SAQMLEEARR REDSLSDSSQ QLQDSLRKKD DRIEELEEAL
860 870 880 890 900
RESVQITAER EMVLAQEESA RTNAEKQVEE LLMAMEKVKQ ELESMKAKLS
910 920 930 940 950
STQQSLAEKE THLTNLRAER RKHLEEVLEM KQEALLAAIS EKDANIALLE
960 970 980 990 1000
LSSSKKKTQE EVAALKREKD RLVQQLKQQT QNRMKLMADN YEDDHFRSSR
1010 1020 1030 1040 1050
SNQTNHKPSP DQIIQPLLEL DQNRSKLKLY IGHLTALCHD RDPLILRGLT
1060 1070 1080 1090 1100
PPASYNADGE QAAWENELQQ MTQEQLQNEL EKVEGDNAEL QEFANTILQQ
1110 1120
IADHCPDILE QVVNALEESS
Length:1,120
Mass (Da):128,331
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA542B526FAEDF9C7
GO
Isoform 2 (identifier: Q99MI1-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     834-877: Missing.
     1013-1020: IIQPLLEL → DEEEGIWA
     1021-1120: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:976
Mass (Da):111,931
Checksum:i48731867C8D8CD6F
GO
Isoform 3 (identifier: Q99MI1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.
     440-467: Missing.
     525-547: DALRLRLEEKETMLNKKTKQIQD → KSFCDLCRIQSIPSFILLYICYV
     548-1120: Missing.

Show »
Length:368
Mass (Da):43,425
Checksum:iA404016D6BD06F06
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VPM7F8VPM7_MOUSE
ELKS/Rab6-interacting/CAST family m...
Erc1
1,120Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXH3V9GXH3_MOUSE
ELKS/Rab6-interacting/CAST family m...
Erc1
992Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GWT6V9GWT6_MOUSE
ELKS/Rab6-interacting/CAST family m...
Erc1
948Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GX53V9GX53_MOUSE
ELKS/Rab6-interacting/CAST family m...
Erc1
720Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXL1V9GXL1_MOUSE
ELKS/Rab6-interacting/CAST family m...
Erc1
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXP8V9GXP8_MOUSE
ELKS/Rab6-interacting/CAST family m...
Erc1
1,116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXF0V9GXF0_MOUSE
ELKS/Rab6-interacting/CAST family m...
Erc1
1,088Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65719 differs from that shown. Artifact. Missing internal sequence that does not correspond to an exon-intron boundary.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti121D → G in BAC35542 (PubMed:16141072).Curated1
Sequence conflicti1070Q → K in BAC65719 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0114561 – 151Missing in isoform 3. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_011457440 – 467Missing in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_011458525 – 547DALRL…KQIQD → KSFCDLCRIQSIPSFILLYI CYV in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_011459548 – 1120Missing in isoform 3. 1 PublicationAdd BLAST573
Alternative sequenceiVSP_011460834 – 877Missing in isoform 2. 2 PublicationsAdd BLAST44
Alternative sequenceiVSP_0114621013 – 1020IIQPLLEL → DEEEGIWA in isoform 2. 2 Publications8
Alternative sequenceiVSP_0114631021 – 1120Missing in isoform 2. 2 PublicationsAdd BLAST100

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF340028 mRNA Translation: AAK26381.1
AF340029 mRNA Translation: AAK26382.1
AY316692 mRNA Translation: AAP83581.1
AK048990 mRNA Translation: BAC33505.1
AK053824 mRNA Translation: BAC35542.1
AK122437 Transcribed RNA Translation: BAC65719.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20476.1 [Q99MI1-4]
CCDS39611.1 [Q99MI1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_835186.1, NM_178085.3 [Q99MI1-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000079582; ENSMUSP00000078534; ENSMUSG00000030172 [Q99MI1-4]
ENSMUST00000184838; ENSMUSP00000139030; ENSMUSG00000030172 [Q99MI1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
111173

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:111173

UCSC genome browser

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UCSCi
uc009dmn.1, mouse [Q99MI1-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF340028 mRNA Translation: AAK26381.1
AF340029 mRNA Translation: AAK26382.1
AY316692 mRNA Translation: AAP83581.1
AK048990 mRNA Translation: BAC33505.1
AK053824 mRNA Translation: BAC35542.1
AK122437 Transcribed RNA Translation: BAC65719.1 Sequence problems.
CCDSiCCDS20476.1 [Q99MI1-4]
CCDS39611.1 [Q99MI1-1]
RefSeqiNP_835186.1, NM_178085.3 [Q99MI1-4]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi226265, 11 interactors
IntActiQ99MI1, 11 interactors
MINTiQ99MI1
STRINGi10090.ENSMUSP00000078534

PTM databases

iPTMnetiQ99MI1
PhosphoSitePlusiQ99MI1

Proteomic databases

EPDiQ99MI1
jPOSTiQ99MI1
PaxDbiQ99MI1
PeptideAtlasiQ99MI1
PRIDEiQ99MI1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
10295, 168 antibodies

Genome annotation databases

EnsembliENSMUST00000079582; ENSMUSP00000078534; ENSMUSG00000030172 [Q99MI1-4]
ENSMUST00000184838; ENSMUSP00000139030; ENSMUSG00000030172 [Q99MI1-2]
GeneIDi111173
KEGGimmu:111173
UCSCiuc009dmn.1, mouse [Q99MI1-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23085
MGIiMGI:2151013, Erc1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG4809, Eukaryota
GeneTreeiENSGT00650000093320
HOGENOMiCLU_815229_0_0_1
InParanoidiQ99MI1
KOiK16072
PhylomeDBiQ99MI1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
111173, 0 hits in 13 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Erc1, mouse

Protein Ontology

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PROi
PR:Q99MI1
RNActiQ99MI1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000030172, Expressed in undifferentiated genital tubercle and 272 other tissues
ExpressionAtlasiQ99MI1, baseline and differential
GenevisibleiQ99MI1, MM

Family and domain databases

InterProiView protein in InterPro
IPR019323, ELKS/CAST
IPR037245, FIP-RBD_C_sf
IPR019018, Rab-bd_FIP-RBD
PfamiView protein in Pfam
PF10174, Cast, 3 hits
PF09457, RBD-FIP, 1 hit
SUPFAMiSSF144270, SSF144270, 1 hit
PROSITEiView protein in PROSITE
PS51511, FIP_RBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRB6I2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99MI1
Secondary accession number(s): Q80TK7
, Q8BPL1, Q8C7Y1, Q99MI2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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