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Protein

Nucleolar GTP-binding protein 1

Gene

Gtpbp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi175 – 182GTPPROSITE-ProRule annotation8
Nucleotide bindingi221 – 225GTPPROSITE-ProRule annotation5
Nucleotide bindingi289 – 292GTPPROSITE-ProRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 1
Alternative name(s):
Chronic renal failure gene protein
GTP-binding protein NGB
Gene namesi
Name:Gtpbp4
Synonyms:Crfg, Nog1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1916487 Gtpbp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001950242 – 634Nucleolar GTP-binding protein 1Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei103N6-acetyllysine; alternateBy similarity1
Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei122PhosphoserineBy similarity1
Cross-linki332Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei468PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Cross-linki534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei558PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99ME9
MaxQBiQ99ME9
PaxDbiQ99ME9
PeptideAtlasiQ99ME9
PRIDEiQ99ME9

PTM databases

iPTMnetiQ99ME9
PhosphoSitePlusiQ99ME9
SwissPalmiQ99ME9

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000021149 Expressed in 284 organ(s), highest expression level in ear vesicle
CleanExiMM_GTPBP4
ExpressionAtlasiQ99ME9 baseline and differential
GenevisibleiQ99ME9 MM

Interactioni

Protein-protein interaction databases

BioGridi213310, 8 interactors
CORUMiQ99ME9
IntActiQ99ME9, 5 interactors
MINTiQ99ME9
STRINGi10090.ENSMUSP00000021574

Structurei

3D structure databases

ProteinModelPortaliQ99ME9
SMRiQ99ME9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 340OBG-type GPROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1490 Eukaryota
COG1084 LUCA
GeneTreeiENSGT00390000018475
HOGENOMiHOG000164071
HOVERGENiHBG052642
InParanoidiQ99ME9
KOiK06943
OMAiSAIMYFM
OrthoDBiEOG091G0476
PhylomeDBiQ99ME9
TreeFamiTF300430

Family and domain databases

InterProiView protein in InterPro
IPR031167 G_OBG
IPR006073 GTP_binding_domain
IPR024926 NOG1
IPR010674 NOG1_Rossman_fold_dom
IPR012973 NOG_C
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
PANTHERiPTHR11702:SF4 PTHR11702:SF4, 1 hit
PfamiView protein in Pfam
PF06858 NOG1, 1 hit
PF08155 NOGCT, 1 hit
PIRSFiPIRSF038919 NOG1, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99ME9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK
60 70 80 90 100
VKFTQQNYHD RLSQILSDFP KLDDIHPFYA DLMNILYDKD HYKLALGQIN
110 120 130 140 150
IAKNLVDNVA KDYVRLMKYG DSLYRCKQLK RAALGRMCTI IKRQRQSLEY
160 170 180 190 200
LEQVRQHLSR LPTIDPNTRT LLLCGYPNVG KSSFINKVTR ADVDVQPYAF
210 220 230 240 250
TTKSLFVGHM DYKYLRWQVV DTPGILDHPL EDRNTIEMQA ITALAHLRAA
260 270 280 290 300
VLYVMDLSEQ CGHGLKEQLE LFQNIRPLFI NKPLIVVANK CDVKRIAELS
310 320 330 340 350
EEDQKIFLDL QAEGFPVIET STLTEEGVIQ VKTEACDRLL AHRVETKMKG
360 370 380 390 400
NKVNEVLNRL HLAVPNKRDD KERPPFIPEG VIARRKRMEI EEPKKKRERD
410 420 430 440 450
LELEMGDDYI LDLQKYWDLM NSSEKYDKIP EIWEGHNVAD YIDPAIMKKL
460 470 480 490 500
EELEKEEELR TAAGEYDSDS ESEDEEMMEI RQLAKQIREK KKLKILQSKE
510 520 530 540 550
KNKQGPRMPR TAKKVQRADL ENEMRSLGVD MDDKNNAHYA VQARRSRSVT
560 570 580 590 600
RKRKREESVP PSSTARSRSC SRTPRDVSGL RDVKMVKKAK TMMKKAQKKM
610 620 630
NRLGKKGEAD RHVFDMKPKH LLSGKRKAGK KDRR
Length:634
Mass (Da):74,113
Last modified:January 23, 2007 - v3
Checksum:i642F42BF8C717D6B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A217FL53A0A217FL53_MOUSE
Nucleolar GTP-binding protein 1
Gtpbp4
164Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17D → E in AAH05514 (PubMed:15489334).Curated1
Sequence conflicti221 – 222DT → TY in AAK13445 (PubMed:11316846).Curated2
Sequence conflicti270E → K in AAK13445 (PubMed:11316846).Curated1
Sequence conflicti288A → T in AAK13445 (PubMed:11316846).Curated1
Sequence conflicti293V → A in AAK13445 (PubMed:11316846).Curated1
Sequence conflicti302E → K in AAK13445 (PubMed:11316846).Curated1
Sequence conflicti341 – 343AHR → THG in AAK13445 (PubMed:11316846).Curated3
Sequence conflicti632D → E in AAK13445 (PubMed:11316846).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348208 mRNA Translation: AAK19749.1
AF325354 mRNA Translation: AAK13445.1
BC005514 mRNA Translation: AAH05514.1
BC025431 mRNA Translation: AAH25431.1
AK011580 mRNA Translation: BAB27714.1
CCDSiCCDS26236.1
RefSeqiNP_081276.2, NM_027000.4
UniGeneiMm.41800

Genome annotation databases

EnsembliENSMUST00000222098; ENSMUSP00000152412; ENSMUSG00000021149
GeneIDi69237
KEGGimmu:69237
UCSCiuc007pkp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348208 mRNA Translation: AAK19749.1
AF325354 mRNA Translation: AAK13445.1
BC005514 mRNA Translation: AAH05514.1
BC025431 mRNA Translation: AAH25431.1
AK011580 mRNA Translation: BAB27714.1
CCDSiCCDS26236.1
RefSeqiNP_081276.2, NM_027000.4
UniGeneiMm.41800

3D structure databases

ProteinModelPortaliQ99ME9
SMRiQ99ME9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213310, 8 interactors
CORUMiQ99ME9
IntActiQ99ME9, 5 interactors
MINTiQ99ME9
STRINGi10090.ENSMUSP00000021574

PTM databases

iPTMnetiQ99ME9
PhosphoSitePlusiQ99ME9
SwissPalmiQ99ME9

Proteomic databases

EPDiQ99ME9
MaxQBiQ99ME9
PaxDbiQ99ME9
PeptideAtlasiQ99ME9
PRIDEiQ99ME9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000222098; ENSMUSP00000152412; ENSMUSG00000021149
GeneIDi69237
KEGGimmu:69237
UCSCiuc007pkp.1 mouse

Organism-specific databases

CTDi23560
MGIiMGI:1916487 Gtpbp4

Phylogenomic databases

eggNOGiKOG1490 Eukaryota
COG1084 LUCA
GeneTreeiENSGT00390000018475
HOGENOMiHOG000164071
HOVERGENiHBG052642
InParanoidiQ99ME9
KOiK06943
OMAiSAIMYFM
OrthoDBiEOG091G0476
PhylomeDBiQ99ME9
TreeFamiTF300430

Miscellaneous databases

PROiPR:Q99ME9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021149 Expressed in 284 organ(s), highest expression level in ear vesicle
CleanExiMM_GTPBP4
ExpressionAtlasiQ99ME9 baseline and differential
GenevisibleiQ99ME9 MM

Family and domain databases

InterProiView protein in InterPro
IPR031167 G_OBG
IPR006073 GTP_binding_domain
IPR024926 NOG1
IPR010674 NOG1_Rossman_fold_dom
IPR012973 NOG_C
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
PANTHERiPTHR11702:SF4 PTHR11702:SF4, 1 hit
PfamiView protein in Pfam
PF06858 NOG1, 1 hit
PF08155 NOGCT, 1 hit
PIRSFiPIRSF038919 NOG1, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOG1_MOUSE
AccessioniPrimary (citable) accession number: Q99ME9
Secondary accession number(s): Q99K16, Q99P78, Q9CT02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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