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Protein

T-box transcription factor TBX19

Gene

Tbx19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi43 – 216T-boxPROSITE-ProRule annotationAdd BLAST174

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX19Curated
Short name:
T-box protein 19
Alternative name(s):
T-box factor, pituitary
Gene namesi
Name:Tbx19Imported
Synonyms:Tpit
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1891158 Tbx19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844501 – 446T-box transcription factor TBX19Add BLAST446

Proteomic databases

PaxDbiQ99ME7
PRIDEiQ99ME7

PTM databases

iPTMnetiQ99ME7
PhosphoSitePlusiQ99ME7

Expressioni

Gene expression databases

BgeeiENSMUSG00000026572 Expressed in 45 organ(s), highest expression level in adenohypophysis
CleanExiMM_TBX19
ExpressionAtlasiQ99ME7 baseline and differential
GenevisibleiQ99ME7 MM

Interactioni

Protein-protein interaction databases

BioGridi219993, 1 interactor
STRINGi10090.ENSMUSP00000027859

Structurei

3D structure databases

ProteinModelPortaliQ99ME7
SMRiQ99ME7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00900000140847
HOGENOMiHOG000063663
HOVERGENiHBG004599
InParanoidiQ99ME7
KOiK10184
OMAiHTSGPIN
OrthoDBiEOG091G05OC
PhylomeDBiQ99ME7
TreeFamiTF106341

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR002070 TF_Brachyury
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00938 BRACHYURY
PR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99ME7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSELATQKAG EGTVSRLLNV VESELQAGRE KGDPTEKQLQ IILEDAPLWQ
60 70 80 90 100
RFKEVTNEMI VTKNGRRMFP VLKISVTGLD PNAMYSLLLD FVRTDSHRWK
110 120 130 140 150
YVNGEWVPAG KPEVSSHSCV YIHPDSPNFG AHWMKAPISF SKVKLTNKLN
160 170 180 190 200
GGGQIMLNSL HKYEPQVHIV RVGGAHRMVM NCSFPETQFI AVTAYQNEEI
210 220 230 240 250
TALKIKYNPF AKAFLDAKER NHLKDVPEAI SESQHVTYSH LGGWILSNPD
260 270 280 290 300
GVCTAANSNY QYATPLPLPA PHTHHGCEHY AGLRGHRQAP YPSAYMHRNH
310 320 330 340 350
SPSVNLIESS SNNLQVFSGP DSWTSLSSTP HASILSVPHS NGPINPGPSP
360 370 380 390 400
YPCLWTISNG GGGPVASGSE VHASTSGTIL LGNPAVTSPS SLLPTQATTS
410 420 430 440
AGVEVLGEPS LTSIAVSTWT AVASHPLPGW GGPGGAGRHS SSSLDS
Length:446
Mass (Da):48,037
Last modified:June 1, 2001 - v1
Checksum:i9BA0995D30547753
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6USC6F6USC6_MOUSE
T-box transcription factor TBX19
Tbx19
318Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348321 mRNA Translation: AAK27153.1
AF345520 mRNA Translation: AAK64365.1
AK038666 mRNA Translation: BAC30088.1
BC120635 mRNA Translation: AAI20636.1
BC137731 mRNA Translation: AAI37732.1
CCDSiCCDS15439.1
RefSeqiNP_114394.1, NM_032005.4
UniGeneiMm.190649

Genome annotation databases

EnsembliENSMUST00000027859; ENSMUSP00000027859; ENSMUSG00000026572
GeneIDi83993
KEGGimmu:83993
UCSCiuc007diw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348321 mRNA Translation: AAK27153.1
AF345520 mRNA Translation: AAK64365.1
AK038666 mRNA Translation: BAC30088.1
BC120635 mRNA Translation: AAI20636.1
BC137731 mRNA Translation: AAI37732.1
CCDSiCCDS15439.1
RefSeqiNP_114394.1, NM_032005.4
UniGeneiMm.190649

3D structure databases

ProteinModelPortaliQ99ME7
SMRiQ99ME7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219993, 1 interactor
STRINGi10090.ENSMUSP00000027859

PTM databases

iPTMnetiQ99ME7
PhosphoSitePlusiQ99ME7

Proteomic databases

PaxDbiQ99ME7
PRIDEiQ99ME7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027859; ENSMUSP00000027859; ENSMUSG00000026572
GeneIDi83993
KEGGimmu:83993
UCSCiuc007diw.1 mouse

Organism-specific databases

CTDi9095
MGIiMGI:1891158 Tbx19

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00900000140847
HOGENOMiHOG000063663
HOVERGENiHBG004599
InParanoidiQ99ME7
KOiK10184
OMAiHTSGPIN
OrthoDBiEOG091G05OC
PhylomeDBiQ99ME7
TreeFamiTF106341

Miscellaneous databases

PROiPR:Q99ME7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026572 Expressed in 45 organ(s), highest expression level in adenohypophysis
CleanExiMM_TBX19
ExpressionAtlasiQ99ME7 baseline and differential
GenevisibleiQ99ME7 MM

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR002070 TF_Brachyury
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00938 BRACHYURY
PR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBX19_MOUSE
AccessioniPrimary (citable) accession number: Q99ME7
Secondary accession number(s): Q0VBH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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