UniProtKB - Q99ME3 (SNCAP_MOUSE)
Protein
Synphilin-1
Gene
Sncaip
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
GO - Biological processi
- cell death Source: MGI
- dopamine metabolic process Source: ParkinsonsUK-UCL
- regulation of inclusion body assembly Source: ParkinsonsUK-UCL
- regulation of neurotransmitter secretion Source: ParkinsonsUK-UCL
Names & Taxonomyi
Protein namesi | Recommended name: Synphilin-1Alternative name(s): Alpha-synuclein-interacting protein |
Gene namesi | Name:Sncaip |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915097, Sncaip |
Subcellular locationi
Nucleus
- nucleoplasm Source: MGI
Other locations
- cytoplasm Source: ParkinsonsUK-UCL
- cytoplasmic ribonucleoprotein granule Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000320071 | 1 – 962 | Synphilin-1Add BLAST | 962 |
Post-translational modificationi
Ubiquitinated; mediated by SIAH1 or RNF19A and leading to its subsequent proteasomal degradation.By similarity
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | Q99ME3 |
MaxQBi | Q99ME3 |
PaxDbi | Q99ME3 |
PRIDEi | Q99ME3 |
PTM databases
iPTMneti | Q99ME3 |
PhosphoSitePlusi | Q99ME3 |
Interactioni
Subunit structurei
Associates with SNCA, RNF19A AND PRKN.
By similarityGO - Molecular functioni
- identical protein binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 212477, 1 interactor |
IntActi | Q99ME3, 3 interactors |
MINTi | Q99ME3 |
STRINGi | 10090.ENSMUSP00000137549 |
Miscellaneous databases
RNActi | Q99ME3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 348 – 379 | ANK 1Add BLAST | 32 | |
Repeati | 383 – 412 | ANK 2Add BLAST | 30 | |
Repeati | 418 – 447 | ANK 3Add BLAST | 30 | |
Repeati | 455 – 484 | ANK 4Add BLAST | 30 | |
Repeati | 602 – 631 | ANK 5Add BLAST | 30 | |
Repeati | 698 – 728 | ANK 6Add BLAST | 31 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 522 – 548 | Sequence analysisAdd BLAST | 27 |
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0504, Eukaryota |
InParanoidi | Q99ME3 |
OrthoDBi | 167171at2759 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR040133, SNCAIP IPR032027, SNCAIP_SNCA-bd |
PANTHERi | PTHR22882, PTHR22882, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF16700, SNCAIP_SNCA_bd, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
Q99ME3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAPEYLDLD EIDFSDDISY SVTSLKTIPA LCRRCDSQNE DRSVSSSGWN
60 70 80 90 100
CGVSTLITNP QKPTGIADVY SKFRPVKRVS PLKHQPETLE NNENEDQKNN
110 120 130 140 150
TVEYQKGGET DQGPQPEELS PEDGVGGLPG KGSEPSQALG ELEHYDLDMD
160 170 180 190 200
EILDVPYIKS SQQLAPLTKV TSEKRILGLC TTINGLSAKT CPIASTENST
210 220 230 240 250
PNMTPFCVLS PVKSPHLRKA PTALRDQHKL STEDSESSPA LGKCGPAYES
260 270 280 290 300
ENHSKDFLNK VFSDPHSRKI EKSGPDCKLR SFHLQSSAAG AKTEEPINGM
310 320 330 340 350
NWTNTQGTEE RTEYLKKVRS ILNIVNEGQI SLLPHLAADN LDKIHDENGN
360 370 380 390 400
NLLHIAASKG HAECLQHLTS LMGEDCLNER NTEQLTPAGL AIKNGQLECV
410 420 430 440 450
RWMVSETEAI AELSCSKDFP SLIHYAGCYG QEKILLWLLQ FMQEQGISLD
460 470 480 490 500
EVDREGNSAV HVASQHGYLG CIQTLVEYGA NVTMQNHAGE KPSQSAERHG
510 520 530 540 550
HTLCSRYLVV VETCMSLASQ VVKLTKQLKE QTVERVTLQS QLQQLLEAQK
560 570 580 590 600
SEGKSLPSSP SSPSSPASTK SQWKALDTDE ESTGKSKVGA QEGIQVLGSL
610 620 630 640 650
SVSSRARTKG KDEDSDKILR QLLGKEISEN VCTQEKLSLE FQDAQASSRN
660 670 680 690 700
SKKIPLEKRE LKLARLRQLM QRSLSESDTD SNNSEDPKNT PVKRADRPRP
710 720 730 740 750
QPIVESVENV DSAESLHLMI KKHSLASGRR FPFGMKASKS LDGHSPSPTS
760 770 780 790 800
ESSEPDLDSH GPGLGMTPPT QPSTEATQSS PDSTAAQKVA TSPKSALKSP
810 820 830 840 850
SSKRRTSQNS KLRVTFEEPV VQMEQTGLEL NGEKDKDKGR APQRTSESGE
860 870 880 890 900
QMKRPFGTFR SIMESLSGNQ NNNNNYQPAS QLKTCTLPLT SLGRKTADAK
910 920 930 940 950
GNPVSPASKG KNKAAMYSSC IHLPSNALVE EHLRDYARHN DIKRNATKTY
960
HMKHTAEPEP RE
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E848 | G5E848_MOUSE | Synphilin-1 | Sncaip | 965 | Annotation score: | ||
Q3V1N2 | Q3V1N2_MOUSE | Synphilin-1 | Sncaip | 914 | Annotation score: | ||
E9Q4E2 | E9Q4E2_MOUSE | Synphilin-1 | Sncaip | 915 | Annotation score: | ||
J3QP58 | J3QP58_MOUSE | Synphilin-1 | Sncaip | 503 | Annotation score: | ||
J3QNK1 | J3QNK1_MOUSE | Synphilin-1 | Sncaip | 855 | Annotation score: | ||
J3KMU0 | J3KMU0_MOUSE | Synphilin-1 | Sncaip | 62 | Annotation score: | ||
A0A0G2JDC8 | A0A0G2JDC8_MOUSE | Synphilin-1 | Sncaip | 10 | Annotation score: | ||
J3QPG2 | J3QPG2_MOUSE | Synphilin-1 | Sncaip | 55 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 805 | R → G in AAK30156 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC130225 mRNA Translation: AAI30226.1 AF348447 mRNA Translation: AAK30156.1 |
RefSeqi | NP_001186080.1, NM_001199151.1 NP_001186082.1, NM_001199153.1 |
Genome annotation databases
GeneIDi | 67847 |
KEGGi | mmu:67847 |
UCSCi | uc008exm.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC130225 mRNA Translation: AAI30226.1 AF348447 mRNA Translation: AAK30156.1 |
RefSeqi | NP_001186080.1, NM_001199151.1 NP_001186082.1, NM_001199153.1 |
3D structure databases
SMRi | Q99ME3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212477, 1 interactor |
IntActi | Q99ME3, 3 interactors |
MINTi | Q99ME3 |
STRINGi | 10090.ENSMUSP00000137549 |
PTM databases
iPTMneti | Q99ME3 |
PhosphoSitePlusi | Q99ME3 |
Proteomic databases
EPDi | Q99ME3 |
MaxQBi | Q99ME3 |
PaxDbi | Q99ME3 |
PRIDEi | Q99ME3 |
Genome annotation databases
GeneIDi | 67847 |
KEGGi | mmu:67847 |
UCSCi | uc008exm.2, mouse |
Organism-specific databases
CTDi | 9627 |
MGIi | MGI:1915097, Sncaip |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota |
InParanoidi | Q99ME3 |
OrthoDBi | 167171at2759 |
Miscellaneous databases
BioGRID-ORCSi | 67847, 1 hit in 17 CRISPR screens |
ChiTaRSi | Sncaip, mouse |
PROi | PR:Q99ME3 |
RNActi | Q99ME3, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR040133, SNCAIP IPR032027, SNCAIP_SNCA-bd |
PANTHERi | PTHR22882, PTHR22882, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF16700, SNCAIP_SNCA_bd, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SNCAP_MOUSE | |
Accessioni | Q99ME3Primary (citable) accession number: Q99ME3 Secondary accession number(s): A2BDD1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | September 18, 2013 | |
Last modified: | December 2, 2020 | |
This is version 103 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot