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Protein

Synphilin-1

Gene

Sncaip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Synphilin-1
Alternative name(s):
Alpha-synuclein-interacting protein
Gene namesi
Name:Sncaip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915097 Sncaip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003200711 – 962Synphilin-1Add BLAST962

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or RNF19A and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ99ME3
MaxQBiQ99ME3
PaxDbiQ99ME3
PRIDEiQ99ME3

PTM databases

iPTMnetiQ99ME3
PhosphoSitePlusiQ99ME3

Expressioni

Gene expression databases

CleanExiMM_SNCAIP

Interactioni

Subunit structurei

Associates with SNCA, RNF19A AND PRKN.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212477, 1 interactor
IntActiQ99ME3, 3 interactors
MINTiQ99ME3
STRINGi10090.ENSMUSP00000025413

Structurei

3D structure databases

ProteinModelPortaliQ99ME3
SMRiQ99ME3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati348 – 379ANK 1Add BLAST32
Repeati383 – 412ANK 2Add BLAST30
Repeati418 – 447ANK 3Add BLAST30
Repeati455 – 484ANK 4Add BLAST30
Repeati602 – 631ANK 5Add BLAST30
Repeati698 – 728ANK 6Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili522 – 548Sequence analysisAdd BLAST27

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
HOVERGENiHBG061375
InParanoidiQ99ME3
KOiK04558

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032027 SNCAIP_SNCA-bd
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16700 SNCAIP_SNCA_bd, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q99ME3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAPEYLDLD EIDFSDDISY SVTSLKTIPA LCRRCDSQNE DRSVSSSGWN
60 70 80 90 100
CGVSTLITNP QKPTGIADVY SKFRPVKRVS PLKHQPETLE NNENEDQKNN
110 120 130 140 150
TVEYQKGGET DQGPQPEELS PEDGVGGLPG KGSEPSQALG ELEHYDLDMD
160 170 180 190 200
EILDVPYIKS SQQLAPLTKV TSEKRILGLC TTINGLSAKT CPIASTENST
210 220 230 240 250
PNMTPFCVLS PVKSPHLRKA PTALRDQHKL STEDSESSPA LGKCGPAYES
260 270 280 290 300
ENHSKDFLNK VFSDPHSRKI EKSGPDCKLR SFHLQSSAAG AKTEEPINGM
310 320 330 340 350
NWTNTQGTEE RTEYLKKVRS ILNIVNEGQI SLLPHLAADN LDKIHDENGN
360 370 380 390 400
NLLHIAASKG HAECLQHLTS LMGEDCLNER NTEQLTPAGL AIKNGQLECV
410 420 430 440 450
RWMVSETEAI AELSCSKDFP SLIHYAGCYG QEKILLWLLQ FMQEQGISLD
460 470 480 490 500
EVDREGNSAV HVASQHGYLG CIQTLVEYGA NVTMQNHAGE KPSQSAERHG
510 520 530 540 550
HTLCSRYLVV VETCMSLASQ VVKLTKQLKE QTVERVTLQS QLQQLLEAQK
560 570 580 590 600
SEGKSLPSSP SSPSSPASTK SQWKALDTDE ESTGKSKVGA QEGIQVLGSL
610 620 630 640 650
SVSSRARTKG KDEDSDKILR QLLGKEISEN VCTQEKLSLE FQDAQASSRN
660 670 680 690 700
SKKIPLEKRE LKLARLRQLM QRSLSESDTD SNNSEDPKNT PVKRADRPRP
710 720 730 740 750
QPIVESVENV DSAESLHLMI KKHSLASGRR FPFGMKASKS LDGHSPSPTS
760 770 780 790 800
ESSEPDLDSH GPGLGMTPPT QPSTEATQSS PDSTAAQKVA TSPKSALKSP
810 820 830 840 850
SSKRRTSQNS KLRVTFEEPV VQMEQTGLEL NGEKDKDKGR APQRTSESGE
860 870 880 890 900
QMKRPFGTFR SIMESLSGNQ NNNNNYQPAS QLKTCTLPLT SLGRKTADAK
910 920 930 940 950
GNPVSPASKG KNKAAMYSSC IHLPSNALVE EHLRDYARHN DIKRNATKTY
960
HMKHTAEPEP RE
Length:962
Mass (Da):105,607
Last modified:September 18, 2013 - v2
Checksum:iAD8980FA1F8E8BCB
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E848G5E848_MOUSE
Synphilin-1
Sncaip mCG_3252
965Annotation score:
Q3V1N2Q3V1N2_MOUSE
Synphilin-1
Sncaip
914Annotation score:
E9Q4E2E9Q4E2_MOUSE
Synphilin-1
Sncaip mCG_3252
915Annotation score:
J3QP58J3QP58_MOUSE
Synphilin-1
Sncaip
503Annotation score:
J3QNK1J3QNK1_MOUSE
Synphilin-1
Sncaip
855Annotation score:
J3KMU0J3KMU0_MOUSE
Synphilin-1
Sncaip
62Annotation score:
A0A0G2JDC8A0A0G2JDC8_MOUSE
Synphilin-1
Sncaip
10Annotation score:
J3QPG2J3QPG2_MOUSE
Synphilin-1
Sncaip
55Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti805R → G in AAK30156 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC130225 mRNA Translation: AAI30226.1
AF348447 mRNA Translation: AAK30156.1
RefSeqiNP_001186080.1, NM_001199151.1
NP_001186082.1, NM_001199153.1
UniGeneiMm.292168

Genome annotation databases

GeneIDi67847
KEGGimmu:67847
UCSCiuc008exm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC130225 mRNA Translation: AAI30226.1
AF348447 mRNA Translation: AAK30156.1
RefSeqiNP_001186080.1, NM_001199151.1
NP_001186082.1, NM_001199153.1
UniGeneiMm.292168

3D structure databases

ProteinModelPortaliQ99ME3
SMRiQ99ME3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212477, 1 interactor
IntActiQ99ME3, 3 interactors
MINTiQ99ME3
STRINGi10090.ENSMUSP00000025413

PTM databases

iPTMnetiQ99ME3
PhosphoSitePlusiQ99ME3

Proteomic databases

EPDiQ99ME3
MaxQBiQ99ME3
PaxDbiQ99ME3
PRIDEiQ99ME3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi67847
KEGGimmu:67847
UCSCiuc008exm.2 mouse

Organism-specific databases

CTDi9627
MGIiMGI:1915097 Sncaip

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
HOVERGENiHBG061375
InParanoidiQ99ME3
KOiK04558

Miscellaneous databases

PROiPR:Q99ME3
SOURCEiSearch...

Gene expression databases

CleanExiMM_SNCAIP

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032027 SNCAIP_SNCA-bd
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16700 SNCAIP_SNCA_bd, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNCAP_MOUSE
AccessioniPrimary (citable) accession number: Q99ME3
Secondary accession number(s): A2BDD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 18, 2013
Last modified: May 23, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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