Wdr6

Functionⁱ

Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.By similarity

GO - Molecular functionⁱ

insulin receptor substrate binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle arrest Source: MGI
negative regulation of autophagy Source: MGI
negative regulation of cell proliferation Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle

Biological process

Cell cycle

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: WD repeat-containing protein 6 Short name: mWDR6
Gene namesⁱ	Name:Wdr6
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:1930140 Wdr6

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000393460	1 – 1125	WD repeat-containing protein 6Add BLAST		1125

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q99ME2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99ME2
PaxDbⁱ	Q99ME2
PRIDEⁱ	Q99ME2

PTM databases

iPTMnetⁱ	Q99ME2
PhosphoSitePlusⁱ	Q99ME2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000066357 Expressed in 294 organ(s), highest expression level in arcuate nucleus of hypothalamus
Genevisibleⁱ	Q99ME2 MM

Interactionⁱ

Subunit structureⁱ

Interacts with STK11/LKB1. Interacts with IRS4 (By similarity).By similarity

GO - Molecular functionⁱ

insulin receptor substrate binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	219954, 1 interactor
STRINGⁱ	10090.ENSMUSP00000070927

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99ME2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	53 – 97	WD 1Add BLAST	45
Repeatⁱ	105 – 143	WD 2Add BLAST	39
Repeatⁱ	147 – 189	WD 3Add BLAST	43
Repeatⁱ	200 – 238	WD 4Add BLAST	39
Repeatⁱ	247 – 285	WD 5Add BLAST	39
Repeatⁱ	289 – 327	WD 6Add BLAST	39
Repeatⁱ	335 – 376	WD 7Add BLAST	42
Repeatⁱ	381 – 422	WD 8Add BLAST	42
Repeatⁱ	425 – 470	WD 9Add BLAST	46
Repeatⁱ	476 – 520	WD 10Add BLAST	45
Repeatⁱ	559 – 598	WD 11Add BLAST	40
Repeatⁱ	604 – 642	WD 12Add BLAST	39
Repeatⁱ	645 – 684	WD 13Add BLAST	40
Repeatⁱ	739 – 785	WD 14Add BLAST	47
Repeatⁱ	848 – 897	WD 15Add BLAST	50
Repeatⁱ	905 – 950	WD 16Add BLAST	46
Repeatⁱ	974 – 1016	WD 17Add BLAST	43
Repeatⁱ	1040 – 1077	WD 18Add BLAST	38
Repeatⁱ	1083 – 1125	WD 19Add BLAST	43

Sequence similaritiesⁱ

Belongs to the WD repeat WDR6 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0974 Eukaryota ENOG410ZJ6J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00420000029923
HOGENOMⁱ	HOG000008701
HOVERGENⁱ	HBG004019
InParanoidⁱ	Q99ME2
OMAⁱ	MHLSSHR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G010D
PhylomeDBⁱ	Q99ME2
TreeFamⁱ	TF313984

Family and domain databases

Gene3Dⁱ	2.130.10.10, 3 hits
InterProⁱ	View protein in InterPro IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 3 hits
SMARTⁱ	View protein in SMART SM00320 WD40, 8 hits
SUPFAMⁱ	SSF50978 SSF50978, 3 hits
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 1 hit PS50294 WD_REPEATS_REGION, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q99ME2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDAFGDYVWP RATSELILLP VTGLECVGDR LLAGEGPDLL VYNLDLGGHL 
        60         70         80         90        100
RMVKRVQNLL GHFLIHGFRV RPEPKGDLDS EAMIAVFGSK GLKVVKVSWG 
       110        120        130        140        150
QSHLRELWRS GLWNMSDWIW DVRWIEGNVA VALGHNSVVL YDPVIGCMLQ 
       160        170        180        190        200
DVPCTDRCTL SSACLVGDTW KELTIVAGAV SNELLIWYPA TALTDNKPVA 
       210        220        230        240        250
PDRRVSGHVG VIFSMSYLES KGLLATASED RSVRLWKVGD LRVPGGRVQN 
       260        270        280        290        300
IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHRGRG 
       310        320        330        340        350
IRAIATHERQ AWVVTGGDDS GIRLWHLAGR GYPGLGVSSL SFKSPSRPGA 
       360        370        380        390        400
LKAVTLAGSW RVLAVTDVGS LYLYDLEVKS WEQLLEDNRF RSYCLLEAAP 
       410        420        430        440        450
GPEGFGLCAL ANGEGLVKVV PINTPTAAVE QKLFQGKVHS LSWALRGYEE 
       460        470        480        490        500
LLLLASGPGG VIACLEISAA PTGKAIFVKE RCRYLLPPSK QRWHTCSAFL 
       510        520        530        540        550
PPGDFLVCGD RRGSVMLFPV RPCLFKKPGA GSKAITAAEA PGAGSGSGGS 
       560        570        580        590        600
ESVPTGIGPV STLHSLHGKQ GVTSVTCHGG YLYSTGRDSS YFQLFVHGGH 
       610        620        630        640        650
LQPVLRQKAC RGMNWVAGLR MVPDGSMVIL GFHANEFVVW SPRSHEKLHI 
       660        670        680        690        700
VNCGGGHRSW AFSDTEAAMA FTYLKDGEVM LYRALGGCIR PNVILREGLH 
       710        720        730        740        750
GREITCVKRV GTVTLGPEFE VPNLEHPDSL EPGSEGPGLI DIVITGSEDT 
       760        770        780        790        800
TVCVLALPTT TGSAHALTSV CNHISSVRAL AVWAVGTPGG PQDTRPGLTA 
       810        820        830        840        850
QVVSAGGRAE IHCFSVMVTP DASTPSRLAC HVMHLSSHRL DEYWDRQRNK 
       860        870        880        890        900
HKMIKVDPET RYMSLAICEL DNDRPGLGPG PLVAAACSDG AVRLFLLQDS 
       910        920        930        940        950
GRILHLLAES FHHKRCVLKV HSFTHEAPNQ RRRLILCSAA TDGSLAFWDL 
       960        970        980        990       1000
TTAMDKGSTT LELPAHPGLP YQMGTPSMTV QAHSCGVNSL HTLPTPEGHH 
      1010       1020       1030       1040       1050
LVASGSEDGS LHVFTLAVKM PEPEEADGEA ELVPQLCVLE EYSVPCAHAA 
      1060       1070       1080       1090       1100
HVTGVKILSP KLMVSASIDQ RLTFWRLGQG EPTFMNSTVY HVPDVADMDC 
      1110       1120 
WPVSPEFGHR CALAGQGLEV YNWYD

Length:1,125

Mass (Da):121,898

Last modified:June 1, 2001 - v1

Checksum:ⁱF228CE5D71554766

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF348591 mRNA Translation: AAK31166.1 AK037181 mRNA Translation: BAC29740.1 AK146617 mRNA Translation: BAE27306.1 AK163752 mRNA Translation: BAE37480.1 CH466560 Genomic DNA Translation: EDL21306.1 BC050894 mRNA Translation: AAH50894.1 BC054367 mRNA Translation: AAH54367.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23532.2
NCBI Reference Sequences More...RefSeqⁱ	NP_113569.1, NM_031392.2
UniGeneⁱ	Mm.335454 Mm.458081

Genome annotation databases

Ensemblⁱ	ENSMUST00000068700; ENSMUSP00000070927; ENSMUSG00000066357
GeneIDⁱ	83669
KEGGⁱ	mmu:83669
UCSC genome browser More...UCSCⁱ	uc009rqj.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99ME2	Wdr6 protein		MOUSE		446	UniRef100_Q99ME2

Protein	Similar proteins		Species	Score	Length	Source
Q99ME2	WD repeat-containing protein 6		RAT		1125	UniRef90_Q5XFW6
Uncharacterized protein		NEOLE		1125
Wdr6 protein		MOUSE		446
WD repeat-containing protein 6		MESAU		1124
WD repeat-containing protein 6		CRIGR		1072
+9

Protein	Similar proteins		Species	Score	Length	Source
Q99ME2	WD repeat-containing protein 6		HUMAN		1121	UniRef50_Q9NNW5
WD repeat-containing protein 6		PONAB		1121
WD repeat-containing protein 6		RAT		1125
WD repeat-containing protein 6		BOVIN		1124
Uncharacterized protein		CERAT		1153
+181

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF348591 mRNA Translation: AAK31166.1 AK037181 mRNA Translation: BAC29740.1 AK146617 mRNA Translation: BAE27306.1 AK163752 mRNA Translation: BAE37480.1 CH466560 Genomic DNA Translation: EDL21306.1 BC050894 mRNA Translation: AAH50894.1 BC054367 mRNA Translation: AAH54367.1
CCDSⁱ	CCDS23532.2
RefSeqⁱ	NP_113569.1, NM_031392.2
UniGeneⁱ	Mm.335454 Mm.458081

3D structure databases

ProteinModelPortalⁱ	Q99ME2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	219954, 1 interactor
STRINGⁱ	10090.ENSMUSP00000070927

PTM databases

iPTMnetⁱ	Q99ME2
PhosphoSitePlusⁱ	Q99ME2

Proteomic databases

EPDⁱ	Q99ME2
MaxQBⁱ	Q99ME2
PaxDbⁱ	Q99ME2
PRIDEⁱ	Q99ME2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000068700; ENSMUSP00000070927; ENSMUSG00000066357
GeneIDⁱ	83669
KEGGⁱ	mmu:83669
UCSCⁱ	uc009rqj.1 mouse

Organism-specific databases

CTDⁱ	11180
MGIⁱ	MGI:1930140 Wdr6

Phylogenomic databases

eggNOGⁱ	KOG0974 Eukaryota ENOG410ZJ6J LUCA
GeneTreeⁱ	ENSGT00420000029923
HOGENOMⁱ	HOG000008701
HOVERGENⁱ	HBG004019
InParanoidⁱ	Q99ME2
OMAⁱ	MHLSSHR
OrthoDBⁱ	EOG091G010D
PhylomeDBⁱ	Q99ME2
TreeFamⁱ	TF313984

Miscellaneous databases

ChiTaRSⁱ	Wdr6 mouse
Protein Ontology More...PROⁱ	PR:Q99ME2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000066357 Expressed in 294 organ(s), highest expression level in arcuate nucleus of hypothalamus
Genevisibleⁱ	Q99ME2 MM

Family and domain databases

Gene3Dⁱ	2.130.10.10, 3 hits
InterProⁱ	View protein in InterPro IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF00400 WD40, 3 hits
SMARTⁱ	View protein in SMART SM00320 WD40, 8 hits
SUPFAMⁱ	SSF50978 SSF50978, 3 hits
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 1 hit PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WDR6_MOUSE
Accessionⁱ	Q99ME2Primary (citable) accession number: Q99ME2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 20, 2010
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99ME2 (WDR6_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

WD repeat-containing protein 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ