UniProtKB - Q99ME2 (WDR6_MOUSE)
Protein
WD repeat-containing protein 6
Gene
Wdr6
Organism
Mus musculus (Mouse)
Status
Functioni
Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.By similarity
GO - Molecular functioni
- insulin receptor substrate binding Source: MGI
GO - Biological processi
- cell cycle arrest Source: MGI
- negative regulation of autophagy Source: MGI
- negative regulation of cell population proliferation Source: MGI
Keywordsi
Biological process | Cell cycle |
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 6Short name: mWDR6 |
Gene namesi | Name:Wdr6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1930140, Wdr6 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Note: Colocalizes in the cytoplasm with STK11/LKB1.By similarity
Cytosol
- cytosol Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- protein-containing complex Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000393460 | 1 – 1125 | WD repeat-containing protein 6Add BLAST | 1125 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q99ME2 |
MaxQBi | Q99ME2 |
PaxDbi | Q99ME2 |
PRIDEi | Q99ME2 |
PTM databases
iPTMneti | Q99ME2 |
PhosphoSitePlusi | Q99ME2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000066357, Expressed in arcuate nucleus of hypothalamus and 308 other tissues |
Genevisiblei | Q99ME2, MM |
Interactioni
Subunit structurei
Interacts with STK11/LKB1.
Interacts with IRS4 (By similarity).
By similarityGO - Molecular functioni
- insulin receptor substrate binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 219954, 35 interactors |
STRINGi | 10090.ENSMUSP00000070927 |
Miscellaneous databases
RNActi | Q99ME2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 53 – 97 | WD 1Add BLAST | 45 | |
Repeati | 105 – 143 | WD 2Add BLAST | 39 | |
Repeati | 147 – 189 | WD 3Add BLAST | 43 | |
Repeati | 200 – 238 | WD 4Add BLAST | 39 | |
Repeati | 247 – 285 | WD 5Add BLAST | 39 | |
Repeati | 289 – 327 | WD 6Add BLAST | 39 | |
Repeati | 335 – 376 | WD 7Add BLAST | 42 | |
Repeati | 381 – 422 | WD 8Add BLAST | 42 | |
Repeati | 425 – 470 | WD 9Add BLAST | 46 | |
Repeati | 476 – 520 | WD 10Add BLAST | 45 | |
Repeati | 559 – 598 | WD 11Add BLAST | 40 | |
Repeati | 604 – 642 | WD 12Add BLAST | 39 | |
Repeati | 645 – 684 | WD 13Add BLAST | 40 | |
Repeati | 739 – 785 | WD 14Add BLAST | 47 | |
Repeati | 848 – 897 | WD 15Add BLAST | 50 | |
Repeati | 905 – 950 | WD 16Add BLAST | 46 | |
Repeati | 974 – 1016 | WD 17Add BLAST | 43 | |
Repeati | 1040 – 1077 | WD 18Add BLAST | 38 | |
Repeati | 1083 – 1125 | WD 19Add BLAST | 43 |
Sequence similaritiesi
Belongs to the WD repeat WDR6 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0974, Eukaryota |
GeneTreei | ENSGT00420000029923 |
HOGENOMi | CLU_002615_0_0_1 |
InParanoidi | Q99ME2 |
OMAi | HFFTGHE |
OrthoDBi | 555109at2759 |
PhylomeDBi | Q99ME2 |
TreeFami | TF313984 |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 3 hits |
SMARTi | View protein in SMART SM00320, WD40, 8 hits |
SUPFAMi | SSF50978, SSF50978, 3 hits |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
Q99ME2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDAFGDYVWP RATSELILLP VTGLECVGDR LLAGEGPDLL VYNLDLGGHL
60 70 80 90 100
RMVKRVQNLL GHFLIHGFRV RPEPKGDLDS EAMIAVFGSK GLKVVKVSWG
110 120 130 140 150
QSHLRELWRS GLWNMSDWIW DVRWIEGNVA VALGHNSVVL YDPVIGCMLQ
160 170 180 190 200
DVPCTDRCTL SSACLVGDTW KELTIVAGAV SNELLIWYPA TALTDNKPVA
210 220 230 240 250
PDRRVSGHVG VIFSMSYLES KGLLATASED RSVRLWKVGD LRVPGGRVQN
260 270 280 290 300
IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHRGRG
310 320 330 340 350
IRAIATHERQ AWVVTGGDDS GIRLWHLAGR GYPGLGVSSL SFKSPSRPGA
360 370 380 390 400
LKAVTLAGSW RVLAVTDVGS LYLYDLEVKS WEQLLEDNRF RSYCLLEAAP
410 420 430 440 450
GPEGFGLCAL ANGEGLVKVV PINTPTAAVE QKLFQGKVHS LSWALRGYEE
460 470 480 490 500
LLLLASGPGG VIACLEISAA PTGKAIFVKE RCRYLLPPSK QRWHTCSAFL
510 520 530 540 550
PPGDFLVCGD RRGSVMLFPV RPCLFKKPGA GSKAITAAEA PGAGSGSGGS
560 570 580 590 600
ESVPTGIGPV STLHSLHGKQ GVTSVTCHGG YLYSTGRDSS YFQLFVHGGH
610 620 630 640 650
LQPVLRQKAC RGMNWVAGLR MVPDGSMVIL GFHANEFVVW SPRSHEKLHI
660 670 680 690 700
VNCGGGHRSW AFSDTEAAMA FTYLKDGEVM LYRALGGCIR PNVILREGLH
710 720 730 740 750
GREITCVKRV GTVTLGPEFE VPNLEHPDSL EPGSEGPGLI DIVITGSEDT
760 770 780 790 800
TVCVLALPTT TGSAHALTSV CNHISSVRAL AVWAVGTPGG PQDTRPGLTA
810 820 830 840 850
QVVSAGGRAE IHCFSVMVTP DASTPSRLAC HVMHLSSHRL DEYWDRQRNK
860 870 880 890 900
HKMIKVDPET RYMSLAICEL DNDRPGLGPG PLVAAACSDG AVRLFLLQDS
910 920 930 940 950
GRILHLLAES FHHKRCVLKV HSFTHEAPNQ RRRLILCSAA TDGSLAFWDL
960 970 980 990 1000
TTAMDKGSTT LELPAHPGLP YQMGTPSMTV QAHSCGVNSL HTLPTPEGHH
1010 1020 1030 1040 1050
LVASGSEDGS LHVFTLAVKM PEPEEADGEA ELVPQLCVLE EYSVPCAHAA
1060 1070 1080 1090 1100
HVTGVKILSP KLMVSASIDQ RLTFWRLGQG EPTFMNSTVY HVPDVADMDC
1110 1120
WPVSPEFGHR CALAGQGLEV YNWYD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF348591 mRNA Translation: AAK31166.1 AK037181 mRNA Translation: BAC29740.1 AK146617 mRNA Translation: BAE27306.1 AK163752 mRNA Translation: BAE37480.1 CH466560 Genomic DNA Translation: EDL21306.1 BC050894 mRNA Translation: AAH50894.1 BC054367 mRNA Translation: AAH54367.1 |
CCDSi | CCDS23532.2 |
RefSeqi | NP_113569.1, NM_031392.2 |
Genome annotation databases
Ensembli | ENSMUST00000068700; ENSMUSP00000070927; ENSMUSG00000066357 |
GeneIDi | 83669 |
KEGGi | mmu:83669 |
UCSCi | uc009rqj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF348591 mRNA Translation: AAK31166.1 AK037181 mRNA Translation: BAC29740.1 AK146617 mRNA Translation: BAE27306.1 AK163752 mRNA Translation: BAE37480.1 CH466560 Genomic DNA Translation: EDL21306.1 BC050894 mRNA Translation: AAH50894.1 BC054367 mRNA Translation: AAH54367.1 |
CCDSi | CCDS23532.2 |
RefSeqi | NP_113569.1, NM_031392.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 219954, 35 interactors |
STRINGi | 10090.ENSMUSP00000070927 |
PTM databases
iPTMneti | Q99ME2 |
PhosphoSitePlusi | Q99ME2 |
Proteomic databases
EPDi | Q99ME2 |
MaxQBi | Q99ME2 |
PaxDbi | Q99ME2 |
PRIDEi | Q99ME2 |
Protocols and materials databases
Antibodypediai | 13436, 91 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000068700; ENSMUSP00000070927; ENSMUSG00000066357 |
GeneIDi | 83669 |
KEGGi | mmu:83669 |
UCSCi | uc009rqj.1, mouse |
Organism-specific databases
CTDi | 11180 |
MGIi | MGI:1930140, Wdr6 |
Phylogenomic databases
eggNOGi | KOG0974, Eukaryota |
GeneTreei | ENSGT00420000029923 |
HOGENOMi | CLU_002615_0_0_1 |
InParanoidi | Q99ME2 |
OMAi | HFFTGHE |
OrthoDBi | 555109at2759 |
PhylomeDBi | Q99ME2 |
TreeFami | TF313984 |
Miscellaneous databases
BioGRID-ORCSi | 83669, 1 hit in 18 CRISPR screens |
ChiTaRSi | Wdr6, mouse |
PROi | PR:Q99ME2 |
RNActi | Q99ME2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000066357, Expressed in arcuate nucleus of hypothalamus and 308 other tissues |
Genevisiblei | Q99ME2, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 3 hits |
SMARTi | View protein in SMART SM00320, WD40, 8 hits |
SUPFAMi | SSF50978, SSF50978, 3 hits |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR6_MOUSE | |
Accessioni | Q99ME2Primary (citable) accession number: Q99ME2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 20, 2010 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families