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Entry version 131 (05 Jun 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Xaa-Pro aminopeptidase 2

Gene

Xpnpep2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.1 Publication EC:3.4.11.9

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the chelating agents 1,10-phenanthroline and EDTA. Inhibited by the thiol-containing compounds 2-mercaptoethanol and dithiothreitol. Also inhibited by apstatin, captopril and p-(ch1oromercuri)benzenesulfonic acid. Weakly inhibited by D,L-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid and N-[l-(R,S)-carboxy-(2-phenylethyl)]-Ala-Ala-Phe-p-aminobenzoate. Inhibited by ramiprilat and enalaprilat, in a Mn2+-dependent manner. Metal ions have a complex substrate- and concentration-dependent effect on activity. Activity towards Arg-Pro-Pro and Gly-Pro-Hyp is stimulated by Mn2+ ion concentrations of 10-100 µM and then inhibited at Mn2+ concentrations of 1-2 mM. Mn2+ concentrations in excess of 2 mM stimulate activity towards Gly-Pro-Hyp but inhibit activity towards Arg-Pro-Pro. Zn2+ and Co2+ ions also inhibit activity towards Arg-Pro-Pro at high concentrations. Activity towards bradykinin is inhibited by Mn2+ concentrations in excess of 1 mM.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.35 mM for Arg-Pro-Pro (at pH 8.0)1 Publication
  2. KM=0.36 mM for Arg-Pro-Pro (at pH 8.0, in the presence of 4 mM Mn2+)1 Publication
  3. KM=0.32 mM for Gly-Pro-Hyp (at pH 8.0)1 Publication
  4. KM=2.0 mM for Gly-Pro-Hyp (at pH 8.0, in the presence of 4 mM Mn2+)1 Publication
  5. KM=0.021 mM for Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg (bradykinin, at pH 6.8)1 Publication
  6. KM=0.039 mM for Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe (at pH 6.8)1 Publication
  7. KM=0.051 mM for Arg-Pro-Pro-Gly-Phe-Ser-Pro (at pH 6.8)1 Publication
  8. KM=0.032 mM for Arg-Pro-Pro-Gly-Phe-Ser (at pH 6.8)1 Publication
  9. KM=0.048 mM for Arg-Pro-Pro-Gly-Phe (at pH 6.8)1 Publication
  10. KM=0.030 mM for Arg-Pro-Pro-Gly (at pH 6.8)1 Publication
  11. KM=1.0 mM for Arg-Pro-Pro (at pH 6.8)1 Publication

    pH dependencei

    Optimum pH is 7.0 for bradykinin. Active between pH 6.0-11.0.1 Publication

    Temperature dependencei

    Thermostable to 55 degrees Celsius. Complete loss of activity above 70-75 degrees Celsius.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei116SubstrateBy similarity1
    Binding sitei430Substrate; via tele nitrogenBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi450Zinc 1By similarity1
    Metal bindingi461Zinc 1By similarity1
    Metal bindingi461Zinc 2By similarity1
    Metal bindingi524Zinc 2; via tele nitrogenBy similarity1
    Binding sitei524Substrate; via tele nitrogenBy similarity1
    Binding sitei533Substrate; via tele nitrogenBy similarity1
    Metal bindingi555Zinc 2By similarity1
    Binding sitei555SubstrateBy similarity1
    Metal bindingi569Zinc 1By similarity1
    Metal bindingi569Zinc 2By similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminopeptidase, Hydrolase, Protease
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-RNO-163125 Post-translational modification: synthesis of GPI-anchored proteins

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M24.005

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Xaa-Pro aminopeptidase 2Curated (EC:3.4.11.91 Publication)
    Alternative name(s):
    Membrane-bound aminopeptidase P1 Publication
    Short name:
    Membrane-bound APP1 Publication
    Short name:
    mAPP1 Publication
    X-prolyl aminopeptidase 2Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Xpnpep2Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

    Organism-specific databases

    Rat genome database

    More...
    RGDi
    621277 Xpnpep2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2970

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500817970323 – 650Xaa-Pro aminopeptidase 21 PublicationAdd BLAST628
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000438730651 – 674Removed in mature formCuratedAdd BLAST24

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi650GPI-anchor amidated alanineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q99MA2

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q99MA2

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed strongly in lung, liver and heart, and at lower levels in kidney, testis, brain, spleen and skeletal muscle.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSRNOG00000004009 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotrimer.

    By similarity

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10116.ENSRNOP00000005604

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q99MA2

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q99MA2

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M24B family.UniRule annotationCurated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2413 Eukaryota
    COG0006 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157196

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000255713

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q99MA2

    KEGG Orthology (KO)

    More...
    KOi
    K14208

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    SPEHLQY

    Database of Orthologous Groups

    More...
    OrthoDBi
    417805at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q99MA2

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314183

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01085 APP, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.350.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029149 Creatin/AminoP/Spt16_NTD
    IPR036005 Creatinase/aminopeptidase-like
    IPR000587 Creatinase_N
    IPR000994 Pept_M24
    IPR033740 Pept_M24B
    IPR032416 Peptidase_M24_C
    IPR001131 Peptidase_M24B_aminopep-P_CS

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01321 Creatinase_N, 1 hit
    PF00557 Peptidase_M24, 1 hit
    PF16188 Peptidase_M24_C, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53092 SSF53092, 1 hit
    SSF55920 SSF55920, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00491 PROLINE_PEPTIDASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99MA2-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAQAYWQCYP WLVLLCACAW SYPGPESLGR EDVRDCSTNP PRLPVTAVNT
    60 70 80 90 100
    TMRLAALRQQ MEKSNLSAYI IPDTDAHMSE YIGKHDERRA WISGFTGSAG
    110 120 130 140 150
    TAVVTKKKAA VWTDSRYWTQ AERQMDCNWE LHKEVSISSI VAWILAEVPD
    160 170 180 190 200
    GENVGFDPFL FSVGSWENYD QELQDSNRHL LSITTNLVDV AWGSERPPVP
    210 220 230 240 250
    SQPIYALPKE FTGSTWQEKV SAIRSYMQNH TMAPTGVLLS ALDETAWLFN
    260 270 280 290 300
    LRSSDIPYNP FFYSYTLLTD SSIRLFVNKS RFSLETLQYL NTNCTLPMCV
    310 320 330 340 350
    QLEDYSQIRD GVKAYASGNV KILIGISYTT YGVYDVIPKE KLVTETYSPV
    360 370 380 390 400
    MLIKAVKNSK EQALLKASHV RDAVAVIQYL VWLEKNVPKG TVDEFSGAEH
    410 420 430 440 450
    IDQLRRNENF SSGPSFETIS ASGLNAALAH YSPTKELHRK LSLDEMYLVD
    460 470 480 490 500
    SGGQYWDGTT DITRTVHWGT PTAFQKEAYT RVLMGNIDLS RLVFPAATSG
    510 520 530 540 550
    RVVEAFARRA LWEVGLNYGH GTGHGIGNFL CVHEWPVGFQ YNNMAMAKGM
    560 570 580 590 600
    FTSIEPGYYQ DGEFGIRLED VALVVEAKTK YPGTYLTFEL VSFVPYDRNL
    610 620 630 640 650
    IDVSLLSPEQ LQYLNRYYQT IRENIGPELQ RRQLLEEFAW LERHTEPLSA
    660 670
    SAPHTTSLAS MWVASALAIL SWSC
    Length:674
    Mass (Da):76,080
    Last modified:June 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10B127E2A3AF51F2
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF359355 mRNA Translation: AAK30297.1
    AC127934 Genomic DNA No translation available.
    AC132991 Genomic DNA No translation available.
    CH473991 Genomic DNA Translation: EDM10905.1
    BC074017 mRNA Translation: AAH74017.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_476496.1, NM_057155.3
    XP_008771735.1, XM_008773513.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSRNOT00000005604; ENSRNOP00000005604; ENSRNOG00000004009

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    117522

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    rno:117522

    UCSC genome browser

    More...
    UCSCi
    RGD:621277 rat

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF359355 mRNA Translation: AAK30297.1
    AC127934 Genomic DNA No translation available.
    AC132991 Genomic DNA No translation available.
    CH473991 Genomic DNA Translation: EDM10905.1
    BC074017 mRNA Translation: AAH74017.1
    RefSeqiNP_476496.1, NM_057155.3
    XP_008771735.1, XM_008773513.2

    3D structure databases

    SMRiQ99MA2
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005604

    Chemistry databases

    BindingDBiQ99MA2
    ChEMBLiCHEMBL2970

    Protein family/group databases

    MEROPSiM24.005

    Proteomic databases

    PaxDbiQ99MA2
    PRIDEiQ99MA2

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSRNOT00000005604; ENSRNOP00000005604; ENSRNOG00000004009
    GeneIDi117522
    KEGGirno:117522
    UCSCiRGD:621277 rat

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    7512
    RGDi621277 Xpnpep2

    Phylogenomic databases

    eggNOGiKOG2413 Eukaryota
    COG0006 LUCA
    GeneTreeiENSGT00940000157196
    HOGENOMiHOG000255713
    InParanoidiQ99MA2
    KOiK14208
    OMAiSPEHLQY
    OrthoDBi417805at2759
    PhylomeDBiQ99MA2
    TreeFamiTF314183

    Enzyme and pathway databases

    ReactomeiR-RNO-163125 Post-translational modification: synthesis of GPI-anchored proteins

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q99MA2

    Gene expression databases

    BgeeiENSRNOG00000004009 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

    Family and domain databases

    CDDicd01085 APP, 1 hit
    Gene3Di3.40.350.10, 2 hits
    InterProiView protein in InterPro
    IPR029149 Creatin/AminoP/Spt16_NTD
    IPR036005 Creatinase/aminopeptidase-like
    IPR000587 Creatinase_N
    IPR000994 Pept_M24
    IPR033740 Pept_M24B
    IPR032416 Peptidase_M24_C
    IPR001131 Peptidase_M24B_aminopep-P_CS
    PfamiView protein in Pfam
    PF01321 Creatinase_N, 1 hit
    PF00557 Peptidase_M24, 1 hit
    PF16188 Peptidase_M24_C, 1 hit
    SUPFAMiSSF53092 SSF53092, 1 hit
    SSF55920 SSF55920, 1 hit
    PROSITEiView protein in PROSITE
    PS00491 PROLINE_PEPTIDASE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPP2_RAT
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99MA2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 18, 2017
    Last sequence update: June 1, 2001
    Last modified: June 5, 2019
    This is version 131 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Peptidase families
      Classification of peptidase families and list of entries
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