Scrt1

Functionⁱ

Transcriptional repressor that binds E-box motif CAGGTG (By similarity). Appears to function downstream of proneural bHLH proteins in promoting neural differentiation.By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	191 – 213	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	222 – 244	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	248 – 270	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	276 – 298	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	304 – 327	C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcriptional repressor scratch 1 Alternative name(s): Scratch homolog 1 zinc finger protein Short name: SCRT Short name: Scratch 1 Short name: mScrt
Gene namesⁱ	Name:Scrt1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:2176606 Scrt1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047037	1 – 348	Transcriptional repressor scratch 1Add BLAST		348

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99M85
PaxDbⁱ	Q99M85
PRIDEⁱ	Q99M85

PTM databases

iPTMnetⁱ	Q99M85
PhosphoSitePlusⁱ	Q99M85

Expressionⁱ

Developmental stageⁱ

Detected throughout the spinal cord except in the ventricular zone surrounding the central canal, which contains proliferating neurons, and dorsal root ganglia at E11.5. At E12.5, detected in the telencephalon, and by E14.5 a distinct laminar pattern of expression was seen in regions adjacent to the ventricular zone. In the developing eye, expression was detected in the inner nuclear layer of the retina beginning at E13.5.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000048385 Expressed in 108 organ(s), highest expression level in lumbar subsegment of spinal cord
Genevisibleⁱ	Q99M85 MM

Interactionⁱ

Subunit structureⁱ

Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains).1 Publication

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000094093

STRINGⁱ

10090.ENSMUSP00000094093

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99M85
SMRⁱ	Q99M85
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 20	SNAG domainBy similarityAdd BLAST		20

Domainⁱ

The N-terminal non zinc-finger region mediates the repressor activity.By similarity

Sequence similaritiesⁱ

Belongs to the snail C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	191 – 213	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	222 – 244	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	248 – 270	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	276 – 298	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	304 – 327	C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2462 Eukaryota ENOG41106JS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011027
HOGENOMⁱ	HOG000261665
HOVERGENⁱ	HBG007477
InParanoidⁱ	Q99M85
KEGG Orthology (KO) More...KOⁱ	K09219
OMAⁱ	AFFIMDG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q0V
PhylomeDBⁱ	Q99M85
TreeFamⁱ	TF315515

Family and domain databases

InterProⁱ	View protein in InterPro IPR029794 SCRATCH1/2 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR44270 PTHR44270, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q99M85-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRSFLVKKV KLDTFSSADL DSSYGRARSD LGVRLQDKGY LSDYVGPASV 
        60         70         80         90        100
YDGDAEAALL KGPSPEPMYA AAVRGELGPA ASGSAPPPTP RPELATAAGG 
       110        120        130        140        150
YINGDAAVSE GYAADAFFIT DGRSRRKAAN ANAAAAPSTA SVAAPDSDAG 
       160        170        180        190        200
GGGGPGTRGS GSGSASRGGT RVGAGTEARA GSGATGAGGR HACGECGKTY 
       210        220        230        240        250
ATSSNLSRHK QTHRSLDSQL ARRCPTCGKV YVSMPAMAMH LLTHDLRHKC 
       260        270        280        290        300
GVCGKAFSRP WLLQGHMRSH TGEKPFGCAH CGKAFADRSN LRAHMQTHSA 
       310        320        330        340 
FKHFQCKRCK KSFALKSYLN KHYESACFKG GASGPATPAP PQLSPVQA

Length:348

Mass (Da):35,919

Last modified:June 1, 2001 - v1

Checksum:ⁱ98734743D56C204F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY014997 mRNA Translation: AAK01468.1 BC057562 mRNA Translation: AAH57562.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS37123.1
NCBI Reference Sequences More...RefSeqⁱ	NP_570963.1, NM_130893.3
UniGeneⁱ	Mm.218747

Genome annotation databases

Ensemblⁱ	ENSMUST00000096365; ENSMUSP00000094093; ENSMUSG00000048385 ENSMUST00000164703; ENSMUSP00000131152; ENSMUSG00000048385
GeneIDⁱ	170729
KEGGⁱ	mmu:170729
UCSC genome browser More...UCSCⁱ	uc007wko.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99M85	Transcriptional repressor scratch 1		HUMAN		348	UniRef90_Q9BWW7
Uncharacterized protein		CERAT		348
Uncharacterized protein		PAPAN		348
Uncharacterized protein		CHLSB		348
Uncharacterized protein		MACNE		348
+54

Protein	Similar proteins		Species	Score	Length	Source
Q99M85	Transcriptional repressor scratch 1		HUMAN		348	UniRef50_Q9BWW7
Transcriptional repressor scratch 2		MOUSE		311
Uncharacterized protein		CERAT		348
Uncharacterized protein		PAPAN		348
Uncharacterized protein		CHLSB		348
+224

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY014997 mRNA Translation: AAK01468.1 BC057562 mRNA Translation: AAH57562.1
CCDSⁱ	CCDS37123.1
RefSeqⁱ	NP_570963.1, NM_130893.3
UniGeneⁱ	Mm.218747

3D structure databases

ProteinModelPortalⁱ	Q99M85
SMRⁱ	Q99M85
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000094093

STRINGⁱ

10090.ENSMUSP00000094093

PTM databases

iPTMnetⁱ	Q99M85
PhosphoSitePlusⁱ	Q99M85

Proteomic databases

MaxQBⁱ	Q99M85
PaxDbⁱ	Q99M85
PRIDEⁱ	Q99M85

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000096365; ENSMUSP00000094093; ENSMUSG00000048385 ENSMUST00000164703; ENSMUSP00000131152; ENSMUSG00000048385
GeneIDⁱ	170729
KEGGⁱ	mmu:170729
UCSCⁱ	uc007wko.1 mouse

Organism-specific databases

CTDⁱ	83482
MGIⁱ	MGI:2176606 Scrt1

Phylogenomic databases

eggNOGⁱ	KOG2462 Eukaryota ENOG41106JS LUCA
GeneTreeⁱ	ENSGT00390000011027
HOGENOMⁱ	HOG000261665
HOVERGENⁱ	HBG007477
InParanoidⁱ	Q99M85
KOⁱ	K09219
OMAⁱ	AFFIMDG
OrthoDBⁱ	EOG091G0Q0V
PhylomeDBⁱ	Q99M85
TreeFamⁱ	TF315515

Miscellaneous databases

ChiTaRSⁱ	Scrt1 mouse
Protein Ontology More...PROⁱ	PR:Q99M85
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000048385 Expressed in 108 organ(s), highest expression level in lumbar subsegment of spinal cord
Genevisibleⁱ	Q99M85 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR029794 SCRATCH1/2 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR44270 PTHR44270, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SCRT1_MOUSE
Accessionⁱ	Q99M85Primary (citable) accession number: Q99M85
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99M85 (SCRT1_MOUSE)

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Transcriptional repressor scratch 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ