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UniProtKB - Q99M80 (PTPRT_MOUSE)

Entry version 158 (02 Dec 2020)
Sequence version 2 (19 Jul 2003)
Previous versions | rss
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Protein

Receptor-type tyrosine-protein phosphatase T

Gene

Ptprt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in both signal transduction and cellular adhesion in the CNS. May have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1065SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1097Phosphocysteine intermediateBy similarity1
Binding sitei1141SubstrateBy similarity1
Active sitei1391Phosphocysteine intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase T (EC:3.1.3.48)
Short name:
R-PTP-T
Alternative name(s):
RPTPmam4
Receptor-type tyrosine-protein phosphatase rho
Short name:
RPTP-rho
Short name:
mRPTPrho
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ptprt
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1321152, Ptprt

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 770ExtracellularSequence analysisAdd BLAST741
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei771 – 791HelicalSequence analysisAdd BLAST21
Topological domaini792 – 1454CytoplasmicSequence analysisAdd BLAST663

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002546430 – 1454Receptor-type tyrosine-protein phosphatase TAdd BLAST1425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi217 ↔ 271PROSITE-ProRule annotation
Glycosylationi425N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi551N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi605N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi658N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi688N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1221PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99M80

PRoteomics IDEntifications database

More...PRIDEi		Q99M80

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q99M80, 10 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99M80

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99M80

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is restricted to the CNS. Distributed throughout the brain and spinal cord.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Exceptionally high levels found in the cortex and olfactory bulbs during perinatal development and are down-regulated during postnatal week 2. Expression in the cerebellar cortex is restricted to the granule cell layer of lobules 1-6. Anterior and posterior compartments become discernible only during postnatal weeks 2 and 6.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000053141, Expressed in retina and 158 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99M80, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99M80, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000105071

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99M80, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99M80

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 195MAMPROSITE-ProRule annotationAdd BLAST162
Domaini197 – 288Ig-like C2-typeAdd BLAST92
Domaini295 – 388Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini393 – 487Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini488 – 594Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST107
Domaini670 – 767Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini902 – 1156Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST255
Domaini1188 – 1450Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST263

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1097 – 1103Substrate bindingBy similarity7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4228, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155326

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001645_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99M80

Identification of Orthologs from Complete Genome Data

More...OMAi		IVECFSV

Database of Orthologous Groups

More...OrthoDBi		411281at2759

TreeFam database of animal gene trees

More...TreeFami		TF312900

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 3 hits
cd06263, MAM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 4 hits
3.90.190.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR000998, MAM_dom
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041, fn3, 2 hits
PF00629, MAM, 1 hit
PF00102, Y_phosphatase, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00020, MAMDOMAIN
PR00700, PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 3 hits
SM00137, MAM, 1 hit
SM00194, PTPc, 2 hits
SM00404, PTPc_motif, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit
SSF49265, SSF49265, 2 hits
SSF49899, SSF49899, 1 hit
SSF52799, SSF52799, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 3 hits
PS50835, IG_LIKE, 1 hit
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 1 hit
PS00383, TYR_PHOSPHATASE_1, 2 hits
PS50056, TYR_PHOSPHATASE_2, 2 hits
PS50055, TYR_PHOSPHATASE_PTP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99M80-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSLGGLALC LLRLLLLGLQ RPPLPGAGAQ SAAGGCSFDE HYSNCGYSVA 
        60         70         80         90        100
LGTNGFTWEQ INTWEKPMLD PAVPTGSFMM VNSSGRASGQ KAHLLLPTLK 
       110        120        130        140        150
ENDTHCIDFH YYFSSRDRSS PGALNVYVKV NGGPQGNPVW NVSGVVTEGW 
       160        170        180        190        200
VKAELAISTF WPHFYQVIFE SVSLKGHPGY IAVDEVRVLA HPCRKAPHFL 
       210        220        230        240        250
RLQNVEVNVG QNATFQCIAG GKWSQHDKLW LQQWNGRDTA LMVTRVVNHR 
       260        270        280        290        300
RFSATVSVAD TSQRSISKYR CVIRSDGGSG VSNYAELIVK EPPTPIAPPE 
       310        320        330        340        350
LLAVGATYLW IKPNANSIIG DGPIILKEVE YRTTTGTWAE THIVDSPNYK 
       360        370        380        390        400
LWHLDPDVEY EIRVLLTRPG EGGTGPPGPP LTTRTKCADP VHGPQNVEIV 
       410        420        430        440        450
DIRARQLTLQ WEPFGYAVTR CHSYNLTVQY QYVFNQQQYE AEEVIQTSSH 
       460        470        480        490        500
YTLRGLRPFM TIRLRLLLSN PEGRMESEEL VVQTEEDVPG AVPLESIQGG 
       510        520        530        540        550
PFEEKIYIQW KPPNETNGVI TLYEINYKAV GSLDPSADLS SQRGKVFKLR 
       560        570        580        590        600
NETHHLFVGL YPGTTYSFTI KASTAKGFGP PVTTRIATKI SAPSMPEYDA 
       610        620        630        640        650
DTPLNETDTT ITVMLKPAQS RGAPVSVYQL VVKEERLQKS RRAADIIECF 
       660        670        680        690        700
SVPVSYRNAS NLDSLHYFAA ELKPSNLPVT QPFTVGDNKT YNGYWNPPLS 
       710        720        730        740        750
PLKSYSIYFQ ALSKANGETK INCVRLATKG APMGSAQVTP GTPLCLLTTA 
       760        770        780        790        800
STQNSNTVEP EKQVDNTVKM AGVIAGLLMF IIILLGVMLT IKRRKLAKKQ 
       810        820        830        840        850
KETQSGAQRE MGPVASTDKP TAKLGTNRND EGFSSSSQDV NGFTDGSRGE 
       860        870        880        890        900
LSQPTLTIQT HPYRTCDPVE MSYPRDQFQP AIRVADLLQH ITQMKRGQGY 
       910        920        930        940        950
GFKEEYEALP EGQTASWDTA KEDENRNKNR YGNIISYDHS RVRLLVLDGD 
       960        970        980        990       1000
PHSDYINANY IDGYHRPRHY IATQGPMQET VKDFWRMIWQ ENSASIVMVT 
      1010       1020       1030       1040       1050
NLVEVGRVKC VRYWPDDTEV YGDIKVTLIE TEPLAEYVIR TFTVQKKGYH 
      1060       1070       1080       1090       1100
EIRELRLFHF TSWPDHGVPC YATGLLGFVR QVKFLNPPEA GPIVVHCSAG 
      1110       1120       1130       1140       1150
AGRTGCFIAI DTMLDMAENE GVVDIFNCVR ELRAQRVNLV QTEEQYVFVH 
      1160       1170       1180       1190       1200
DAILEACLCG NTAIPVCEFR SLYYNISRLD PQTNSSQIKD EFQTLNIVTP 
      1210       1220       1230       1240       1250
RVRPEDCSIG LLPRNHDKNR SMDVLPLDRC LPFLISVDGE SSNYINAALM 
      1260       1270       1280       1290       1300
DSHKQPAAFV VTQHPLPNTV ADFWRLVFDY NCSSVVMLNE MDTAQLCMQY 
      1310       1320       1330       1340       1350
WPEKTSGCYG PIQVEFVSAD IDEDIIHRIF RICNMARPQD GYRIVQHLQY 
      1360       1370       1380       1390       1400
IGWPAYRDTP PSKRSLLKVV RRLEKWQEQY DGREGRTVVH CLNGGGRSGT 
      1410       1420       1430       1440       1450
FCAICSVCEM IQQQNIIDVF HIVKTLRNNK SNMVETLEQY KFVYEVALEY 

LSSF
Length:1,454
Mass (Da):163,012
Last modified:July 19, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC60464F7B423F8A8
GO
Isoform 2 (identifier: Q99M80-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     731-749: Missing.
     1007-1007: R → RHPAEHTVGTATLGRAASPGM

Show »
Length:1,455
Mass (Da):163,115
Checksum:i95293974FAEA85A0
GO
Isoform 3 (identifier: Q99M80-3) [UniParc]FASTAAdd to basket
Also known as: RPTPrho2

The sequence of this isoform differs from the canonical sequence as follows:
     731-749: Missing.
     794-794: R → RRNAYSYSYYL

Show »
Length:1,445
Mass (Da):162,453
Checksum:i1879E76330FE2329
GO
Isoform 4 (identifier: Q99M80-4) [UniParc]FASTAAdd to basket
Also known as: RPTPrho1

The sequence of this isoform differs from the canonical sequence as follows:
     731-749: Missing.

Show »
Length:1,435
Mass (Da):161,172
Checksum:i37E558F82049F50C
GO
Isoform 5 (identifier: Q99M80-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     731-749: Missing.
     794-794: R → RRNAYSYSYYLSQR

Show »
Length:1,448
Mass (Da):162,825
Checksum:iAF638DD3EA12DC5A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AQN2B1AQN2_MOUSE
Protein-tyrosine-phosphatase
Ptprt
1,454Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13 – 16Missing in AAD34158 (PubMed:11423001).Curated4
Sequence conflicti21R → P in AAD34158 (PubMed:11423001).Curated1
Sequence conflicti34 – 37GGCS → RGVF in AAD34158 (PubMed:11423001).Curated4
Sequence conflicti87A → T in AAF82401 (Ref. 4) Curated1
Sequence conflicti254A → S in AAF82401 (Ref. 4) Curated1
Sequence conflicti266I → V in AAF82401 (Ref. 4) Curated1
Sequence conflicti602T → S in AAF82401 (Ref. 4) Curated1
Sequence conflicti822A → T in AAF82401 (Ref. 4) Curated1
Sequence conflicti825G → S in AAF82401 (Ref. 4) Curated1
Sequence conflicti844 – 845TD → N in AAF82401 (Ref. 4) Curated2
Sequence conflicti1016D → A in AAF82401 (Ref. 4) Curated1
Sequence conflicti1049Y → H in AAD34158 (PubMed:11423001).Curated1
Sequence conflicti1050H → N in AAF82401 (Ref. 4) Curated1
Sequence conflicti1076L → V in AAF82401 (Ref. 4) Curated1
Sequence conflicti1103R → K in AAD34158 (PubMed:11423001).Curated1
Sequence conflicti1259F → L in AAF82401 (Ref. 4) Curated1
Sequence conflicti1266L → I in AAF82401 (Ref. 4) Curated1
Sequence conflicti1269T → S in AAF82401 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007803731 – 749Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST19
Alternative sequenceiVSP_007804794R → RRNAYSYSYYL in isoform 3. 2 Publications1
Alternative sequenceiVSP_007805794R → RRNAYSYSYYLSQR in isoform 5. 1 Publication1
Alternative sequenceiVSP_0078061007R → RHPAEHTVGTATLGRAASPG M in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF152556 mRNA Translation: AAD34158.4
AY026861 mRNA Translation: AAK18741.1
AY026862 mRNA Translation: AAK18742.1
AY026863 mRNA Translation: AAK18743.1
AF244125 mRNA Translation: AAF44712.1
AF162856 mRNA Translation: AAF82400.2
AF162857 mRNA Translation: AAF82401.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS17001.1 [Q99M80-4]
CCDS71182.1 [Q99M80-2]
CCDS71183.1 [Q99M80-3]

NCBI Reference Sequences

More...RefSeqi		NP_001278078.1, NM_001291149.1 [Q99M80-2]
NP_001278079.1, NM_001291150.1 [Q99M80-3]
NP_067439.1, NM_021464.5 [Q99M80-4]
XP_011237686.1, XM_011239384.2 [Q99M80-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000109441; ENSMUSP00000105067; ENSMUSG00000053141 [Q99M80-2]
ENSMUST00000109443; ENSMUSP00000105069; ENSMUSG00000053141 [Q99M80-3]
ENSMUST00000109445; ENSMUSP00000105071; ENSMUSG00000053141 [Q99M80-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		19281

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:19281

UCSC genome browser

More...UCSCi		uc008nrw.2, mouse [Q99M80-4]
uc008nrx.2, mouse [Q99M80-3]
uc008nrz.2, mouse [Q99M80-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152556 mRNA Translation: AAD34158.4
AY026861 mRNA Translation: AAK18741.1
AY026862 mRNA Translation: AAK18742.1
AY026863 mRNA Translation: AAK18743.1
AF244125 mRNA Translation: AAF44712.1
AF162856 mRNA Translation: AAF82400.2
AF162857 mRNA Translation: AAF82401.1
CCDSiCCDS17001.1 [Q99M80-4]
CCDS71182.1 [Q99M80-2]
CCDS71183.1 [Q99M80-3]
RefSeqiNP_001278078.1, NM_001291149.1 [Q99M80-2]
NP_001278079.1, NM_001291150.1 [Q99M80-3]
NP_067439.1, NM_021464.5 [Q99M80-4]
XP_011237686.1, XM_011239384.2 [Q99M80-5]

3D structure databases

SMRiQ99M80
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105071

PTM databases

GlyGeniQ99M80, 10 sites
iPTMnetiQ99M80
PhosphoSitePlusiQ99M80

Proteomic databases

PaxDbiQ99M80
PRIDEiQ99M80

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2780, 107 antibodies

The DNASU plasmid repository

More...DNASUi		19281

Genome annotation databases

EnsembliENSMUST00000109441; ENSMUSP00000105067; ENSMUSG00000053141 [Q99M80-2]
ENSMUST00000109443; ENSMUSP00000105069; ENSMUSG00000053141 [Q99M80-3]
ENSMUST00000109445; ENSMUSP00000105071; ENSMUSG00000053141 [Q99M80-4]
GeneIDi19281
KEGGimmu:19281
UCSCiuc008nrw.2, mouse [Q99M80-4]
uc008nrx.2, mouse [Q99M80-3]
uc008nrz.2, mouse [Q99M80-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11122
MGIiMGI:1321152, Ptprt

Phylogenomic databases

eggNOGiKOG4228, Eukaryota
GeneTreeiENSGT00940000155326
HOGENOMiCLU_001645_0_1_1
InParanoidiQ99M80
OMAiIVECFSV
OrthoDBi411281at2759
TreeFamiTF312900

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		19281, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ptprt, mouse

Protein Ontology

More...PROi		PR:Q99M80
RNActiQ99M80, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000053141, Expressed in retina and 158 other tissues
ExpressionAtlasiQ99M80, baseline and differential
GenevisibleiQ99M80, MM

Family and domain databases

CDDicd00063, FN3, 3 hits
cd06263, MAM, 1 hit
Gene3Di2.60.40.10, 4 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR000998, MAM_dom
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041, fn3, 2 hits
PF00629, MAM, 1 hit
PF00102, Y_phosphatase, 2 hits
PRINTSiPR00020, MAMDOMAIN
PR00700, PRTYPHPHTASE
SMARTiView protein in SMART
SM00060, FN3, 3 hits
SM00137, MAM, 1 hit
SM00194, PTPc, 2 hits
SM00404, PTPc_motif, 2 hits
SUPFAMiSSF48726, SSF48726, 1 hit
SSF49265, SSF49265, 2 hits
SSF49899, SSF49899, 1 hit
SSF52799, SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 3 hits
PS50835, IG_LIKE, 1 hit
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 1 hit
PS00383, TYR_PHOSPHATASE_1, 2 hits
PS50056, TYR_PHOSPHATASE_2, 2 hits
PS50055, TYR_PHOSPHATASE_PTP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPRT_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99M80
Secondary accession number(s): Q99M81
, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: December 2, 2020
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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