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Entry version 161 (02 Dec 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Cytoplasmic protein NCK1

Gene

Nck1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranslation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-186763, Downstream signal transduction
R-MMU-202433, Generation of second messenger molecules
R-MMU-373753, Nephrin family interactions
R-MMU-418885, DCC mediated attractive signaling
R-MMU-4420097, VEGFA-VEGFR2 Pathway
R-MMU-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic protein NCK1
Alternative name(s):
NCK adaptor protein 1
Short name:
Nck-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nck1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109601, Nck1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004138012 – 377Cytoplasmic protein NCK1Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei85PhosphoserineCombined sources1
Modified residuei91PhosphoserineBy similarity1
Modified residuei96PhosphoserineBy similarity1
Modified residuei105PhosphotyrosineCombined sources1
Modified residuei166PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99M51

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99M51

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99M51

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99M51

PeptideAtlas

More...
PeptideAtlasi
Q99M51

PRoteomics IDEntifications database

More...
PRIDEi
Q99M51

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00453999

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99M51

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99M51

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032475, Expressed in adult mammalian kidney and 283 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99M51, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99M51, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with BLNK, PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion.

Interacts with SOCS7. This interaction is required for nuclear import.

Part of a complex containing PPP1R15B, PP1 and NCK1.

Interacts with RALGPS1.

Interacts with CAV2 (tyrosine phosphorylated form).

Interacts with ADAM15.

Interacts with FASLG. Directly interacts with RASA1.

Interacts with MINK1.

Interacts with KDR (tyrosine phosphorylated).

Interacts (via SH2 domain) with EPHB1; activates the JUN cascade to regulate cell adhesion.

Interacts with EPHA2.

Interacts (via SH2 domain) with PDGFRB (tyrosine phosphorylated).

Interacts (via SH2 domain and SH3 domain 2) with EGFR.

Interacts with PAK1 and SOS1.

Interacts (via SH3 domains) with PKN2 (By similarity).

Interacts with FLT1 (tyrosine phosphorylated).

Interacts with the inactive form of EIF2AK2/PKR (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
201704, 49 interactors

Database of interacting proteins

More...
DIPi
DIP-37524N

Protein interaction database and analysis system

More...
IntActi
Q99M51, 17 interactors

Molecular INTeraction database

More...
MINTi
Q99M51

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000112221

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99M51, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q99M51

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99M51

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 61SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini106 – 165SH3 2PROSITE-ProRule annotationAdd BLAST60
Domaini190 – 252SH3 3PROSITE-ProRule annotationAdd BLAST63
Domaini282 – 376SH2PROSITE-ProRule annotationAdd BLAST95

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Only the first and third SH3 domains seem to be involved in RASA1-binding; the second SH3 domain and the SH2 domains do not seem to be involved.By similarity

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4226, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156601

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025160_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99M51

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTGMRET

Database of Orthologous Groups

More...
OrthoDBi
1097449at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99M51

TreeFam database of animal gene trees

More...
TreeFami
TF351631

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10408, SH2_Nck1, 1 hit
cd11900, SH3_Nck1_1, 1 hit
cd11901, SH3_Nck1_2, 1 hit
cd11904, SH3_Nck1_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017304, NCK
IPR035882, Nck1_SH2
IPR035562, Nck1_SH3_1
IPR035564, Nck1_SH3_2
IPR035565, Nck1_SH3_3
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00017, SH2, 1 hit
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037874, Cytoplasmic_NCK, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401, SH2DOMAIN
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 3 hits
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001, SH2, 1 hit
PS50002, SH3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99M51-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNKTGF
60 70 80 90 100
VPSNYVERKN SARKASIVKN LKDTLGIGKV KRKPSVPDTA SPADDSFVDP
110 120 130 140 150
GERLYDLNMP AFVKFNYMAE REDELSLIKG TKVIVMEKCS DGWWRGSYNG
160 170 180 190 200
QIGWFPSNYV TEEGDSPLGD HVGSLSEKLA AVVNNLNTGQ VLHVVQALYP
210 220 230 240 250
FSSSNDEELN FEKGDVMDVI EKPENDPEWW KCRKINGMVG LVPKNYVTIM
260 270 280 290 300
QNNPLTSGLE PSPPQCDYIR PSLTGKFAGN PWYYGKVTRH QAEMALNERG
310 320 330 340 350
HEGDFLIRDS ESSPNDFSVS LKAQGKNKHF KVQLKETVYC IGQRKFSTME
360 370
ELVEHYKKAP IFTSEQGEKL YLVKHLS
Length:377
Mass (Da):42,891
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i671BBFC870A88EB9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BH99Q8BH99_MOUSE
Cytoplasmic protein NCK1
Nck1
313Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WSB1A0A087WSB1_MOUSE
Cytoplasmic protein NCK1
Nck1
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQD1A0A087WQD1_MOUSE
Cytoplasmic protein NCK1
Nck1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4E → G in AAD13752 (Ref. 1) Curated1
Sequence conflicti4E → G in AAC06352 (Ref. 2) Curated1
Sequence conflicti30W → C in AAC06352 (Ref. 2) Curated1
Sequence conflicti74T → N in AAC06352 (Ref. 2) Curated1
Sequence conflicti84P → T in AAC06352 (Ref. 2) Curated1
Sequence conflicti90A → E in AAC06352 (Ref. 2) Curated1
Sequence conflicti155 – 157FPS → LPC in AAC06352 (Ref. 2) Curated3
Sequence conflicti202S → G in AAC06352 (Ref. 2) Curated1
Sequence conflicti206D → N in AAC06352 (Ref. 2) Curated1
Sequence conflicti307I → V in AAC06352 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF084183 mRNA Translation: AAD13752.1
AF043259 mRNA Translation: AAC06352.1
AC129223 Genomic DNA No translation available.
CH466560 Genomic DNA Translation: EDL21028.1
CH466560 Genomic DNA Translation: EDL21029.1
CH466560 Genomic DNA Translation: EDL21031.1
BC002015 mRNA Translation: AAH02015.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23440.1

NCBI Reference Sequences

More...
RefSeqi
NP_035008.2, NM_010878.3
XP_006510903.1, XM_006510840.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000116522; ENSMUSP00000112221; ENSMUSG00000032475

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17973

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17973

UCSC genome browser

More...
UCSCi
uc009rex.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084183 mRNA Translation: AAD13752.1
AF043259 mRNA Translation: AAC06352.1
AC129223 Genomic DNA No translation available.
CH466560 Genomic DNA Translation: EDL21028.1
CH466560 Genomic DNA Translation: EDL21029.1
CH466560 Genomic DNA Translation: EDL21031.1
BC002015 mRNA Translation: AAH02015.1
CCDSiCCDS23440.1
RefSeqiNP_035008.2, NM_010878.3
XP_006510903.1, XM_006510840.2

3D structure databases

BMRBiQ99M51
SMRiQ99M51
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201704, 49 interactors
DIPiDIP-37524N
IntActiQ99M51, 17 interactors
MINTiQ99M51
STRINGi10090.ENSMUSP00000112221

PTM databases

iPTMnetiQ99M51
PhosphoSitePlusiQ99M51

2D gel databases

REPRODUCTION-2DPAGEiIPI00453999

Proteomic databases

EPDiQ99M51
jPOSTiQ99M51
MaxQBiQ99M51
PaxDbiQ99M51
PeptideAtlasiQ99M51
PRIDEiQ99M51

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3567, 538 antibodies

Genome annotation databases

EnsembliENSMUST00000116522; ENSMUSP00000112221; ENSMUSG00000032475
GeneIDi17973
KEGGimmu:17973
UCSCiuc009rex.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4690
MGIiMGI:109601, Nck1

Phylogenomic databases

eggNOGiKOG4226, Eukaryota
GeneTreeiENSGT00940000156601
HOGENOMiCLU_025160_0_1_1
InParanoidiQ99M51
OMAiKTGMRET
OrthoDBi1097449at2759
PhylomeDBiQ99M51
TreeFamiTF351631

Enzyme and pathway databases

ReactomeiR-MMU-186763, Downstream signal transduction
R-MMU-202433, Generation of second messenger molecules
R-MMU-373753, Nephrin family interactions
R-MMU-418885, DCC mediated attractive signaling
R-MMU-4420097, VEGFA-VEGFR2 Pathway
R-MMU-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
17973, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Nck1, mouse

Protein Ontology

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PROi
PR:Q99M51
RNActiQ99M51, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000032475, Expressed in adult mammalian kidney and 283 other tissues
ExpressionAtlasiQ99M51, baseline and differential
GenevisibleiQ99M51, MM

Family and domain databases

CDDicd10408, SH2_Nck1, 1 hit
cd11900, SH3_Nck1_1, 1 hit
cd11901, SH3_Nck1_2, 1 hit
cd11904, SH3_Nck1_3, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR017304, NCK
IPR035882, Nck1_SH2
IPR035562, Nck1_SH3_1
IPR035564, Nck1_SH3_2
IPR035565, Nck1_SH3_3
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00017, SH2, 1 hit
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit
PIRSFiPIRSF037874, Cytoplasmic_NCK, 1 hit
PRINTSiPR00401, SH2DOMAIN
PR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 3 hits
SUPFAMiSSF50044, SSF50044, 3 hits
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001, SH2, 1 hit
PS50002, SH3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCK1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99M51
Secondary accession number(s): O55032, Q9Z279
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2011
Last sequence update: June 1, 2001
Last modified: December 2, 2020
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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