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Protein

Proline-serine-threonine phosphatase-interacting protein 2

Gene

Pstpip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to F-actin. May be involved in regulation of the actin cytoskeleton.

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-serine-threonine phosphatase-interacting protein 2
Short name:
PEST phosphatase-interacting protein 2
Alternative name(s):
Macrophage actin-associated tyrosine-phosphorylated protein
pp37
Gene namesi
Name:Pstpip2
Synonyms:Mayp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1335088 Pstpip2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000585422 – 334Proline-serine-threonine phosphatase-interacting protein 2Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei323PhosphotyrosineCombined sources1
Modified residuei329PhosphotyrosineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99M15
PaxDbiQ99M15
PRIDEiQ99M15

PTM databases

iPTMnetiQ99M15
PhosphoSitePlusiQ99M15

Expressioni

Tissue specificityi

Expressed in macrophage-containing tissues, including bone marrow, spleen, liver, kidney, intestine and brain.

Gene expression databases

BgeeiENSMUSG00000025429 Expressed in 133 organ(s), highest expression level in secondary oocyte
GenevisibleiQ99M15 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Ptpn18Q611527EBI-8653964,EBI-7074223

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ99M15, 3 interactors
MINTiQ99M15
STRINGi10090.ENSMUSP00000110389

Structurei

3D structure databases

ProteinModelPortaliQ99M15
SMRiQ99M15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 264F-BARPROSITE-ProRule annotationAdd BLAST261

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili66 – 163Sequence analysisAdd BLAST98

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IU8M Eukaryota
ENOG411036U LUCA
GeneTreeiENSGT00930000150876
HOGENOMiHOG000294218
HOVERGENiHBG052960
InParanoidiQ99M15
KOiK20124
OMAiCRDKEEA
OrthoDBiEOG091G09F9
TreeFamiTF313677

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR030106 PSTPIP2
PANTHERiPTHR23065:SF9 PTHR23065:SF9, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99M15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGSLFKGNF WSTDILSTIG YDSIIQHLNN GRKNCKEFED FLKERASIEE
60 70 80 90 100
KYGKDLLNLS RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQTLRE
110 120 130 140 150
EARKMEEFRE KQKLQRKKTE TIMDAAHKQR NAQFKKAMDA KKNYEQKCRD
160 170 180 190 200
KDEAEQAVHR SANVANQRQQ EKLFVKLATS KTAVEDSDKA YMLHINMLEK
210 220 230 240 250
VREDWQSEHI KACEVFEAQE CERINFFRNA LWLHLNQLSQ QCVANDEMYE
260 270 280 290 300
QVRKSLETCS IEKDIQYFVN QRKTGQTPPA PIMYENFYSP QRNAAPPGKT
310 320 330
TGPNPARRGP LPVPKRIPDD PDYSVVEDYS LLYQ
Length:334
Mass (Da):38,948
Last modified:July 27, 2011 - v4
Checksum:i77B4B0F7BB06095B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298G → E in AAH02123 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18101 mRNA Translation: CAA77027.1
AK132418 mRNA Translation: BAE21158.1
AK154724 mRNA Translation: BAE32788.1
AK157994 mRNA Translation: BAE34306.1
BC002123 mRNA Translation: AAH02123.1
BC057654 mRNA Translation: AAH57654.1
CCDSiCCDS37868.1
RefSeqiNP_038859.3, NM_013831.4
UniGeneiMm.57174

Genome annotation databases

EnsembliENSMUST00000114741; ENSMUSP00000110389; ENSMUSG00000025429
ENSMUST00000230626; ENSMUSP00000155048; ENSMUSG00000116035
GeneIDi19201
KEGGimmu:19201
UCSCiuc008fry.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18101 mRNA Translation: CAA77027.1
AK132418 mRNA Translation: BAE21158.1
AK154724 mRNA Translation: BAE32788.1
AK157994 mRNA Translation: BAE34306.1
BC002123 mRNA Translation: AAH02123.1
BC057654 mRNA Translation: AAH57654.1
CCDSiCCDS37868.1
RefSeqiNP_038859.3, NM_013831.4
UniGeneiMm.57174

3D structure databases

ProteinModelPortaliQ99M15
SMRiQ99M15
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99M15, 3 interactors
MINTiQ99M15
STRINGi10090.ENSMUSP00000110389

PTM databases

iPTMnetiQ99M15
PhosphoSitePlusiQ99M15

Proteomic databases

MaxQBiQ99M15
PaxDbiQ99M15
PRIDEiQ99M15

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114741; ENSMUSP00000110389; ENSMUSG00000025429
ENSMUST00000230626; ENSMUSP00000155048; ENSMUSG00000116035
GeneIDi19201
KEGGimmu:19201
UCSCiuc008fry.1 mouse

Organism-specific databases

CTDi9050
MGIiMGI:1335088 Pstpip2

Phylogenomic databases

eggNOGiENOG410IU8M Eukaryota
ENOG411036U LUCA
GeneTreeiENSGT00930000150876
HOGENOMiHOG000294218
HOVERGENiHBG052960
InParanoidiQ99M15
KOiK20124
OMAiCRDKEEA
OrthoDBiEOG091G09F9
TreeFamiTF313677

Miscellaneous databases

PROiPR:Q99M15
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025429 Expressed in 133 organ(s), highest expression level in secondary oocyte
GenevisibleiQ99M15 MM

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR030106 PSTPIP2
PANTHERiPTHR23065:SF9 PTHR23065:SF9, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPIP2_MOUSE
AccessioniPrimary (citable) accession number: Q99M15
Secondary accession number(s): Q6GTF6, Q9Z189
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 128 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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