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Protein

GrpE protein homolog 1, mitochondrial

Gene

Grpel1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog 1, mitochondrial
Alternative name(s):
Mt-GrpE#1
Gene namesi
Name:Grpel1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1334417 Grpel1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionBy similarityAdd BLAST27
ChainiPRO_000001305028 – 217GrpE protein homolog 1, mitochondrialAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94N6-acetyllysine; alternateCombined sources1
Modified residuei94N6-succinyllysine; alternateCombined sources1
Modified residuei100N6-acetyllysineCombined sources1
Modified residuei120N6-succinyllysineCombined sources1
Modified residuei215N6-acetyllysine; alternateCombined sources1
Modified residuei215N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99LP6
MaxQBiQ99LP6
PaxDbiQ99LP6
PeptideAtlasiQ99LP6
PRIDEiQ99LP6

2D gel databases

UCD-2DPAGEiQ99LP6

PTM databases

iPTMnetiQ99LP6
PhosphoSitePlusiQ99LP6
SwissPalmiQ99LP6

Expressioni

Gene expression databases

BgeeiENSMUSG00000029198 Expressed in 292 organ(s), highest expression level in brown adipose tissue
CleanExiMM_GRPEL1
GenevisibleiQ99LP6 MM

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19. Binds to HSP70, HSC70 and HSJ1B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ99LP6, 4 interactors
MINTiQ99LP6
STRINGi10090.ENSMUSP00000031099

Structurei

3D structure databases

ProteinModelPortaliQ99LP6
SMRiQ99LP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003 Eukaryota
COG0576 LUCA
GeneTreeiENSGT00390000005589
HOGENOMiHOG000252083
HOVERGENiHBG051846
InParanoidiQ99LP6
KOiK03687
OMAiYAYEKIA
OrthoDBiEOG091G0O5D
PhylomeDBiQ99LP6
TreeFamiTF105284

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99LP6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARCVRLAR RSLPALALSF RPSPRLLCTA TKQKNNGQNL DEDLGHCEPK
60 70 80 90 100
TDPPSADKTL LEEKAKLEEQ LRETMEKYKR ALADTENLRQ RSQKLVEEAK
110 120 130 140 150
LYGIQGFCKD LLEVADILEK ATQSVPKEEI SNNNPHLKSL YEGLVMTEVQ
160 170 180 190 200
IQKVFTKHGL LRLDPIGAKF DPYEHEALFH TPVEGKEPGT VALVSKVGYK
210
LHGRTLRPAL VGVVKDA
Length:217
Mass (Da):24,307
Last modified:June 1, 2001 - v1
Checksum:iBE7A6D26A9C5B329
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048732 mRNA Translation: BAC33437.1
AK050445 mRNA Translation: BAC34257.1
AK089113 mRNA Translation: BAC40758.1
AK161688 mRNA Translation: BAE36532.1
BC002284 mRNA Translation: AAH02284.1
CCDSiCCDS19238.1
RefSeqiNP_077798.1, NM_024478.2
UniGeneiMm.21535

Genome annotation databases

EnsembliENSMUST00000031099; ENSMUSP00000031099; ENSMUSG00000029198
GeneIDi17713
KEGGimmu:17713
UCSCiuc008xep.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGRPE1_MOUSE
AccessioniPrimary (citable) accession number: Q99LP6
Secondary accession number(s): Q3TSZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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