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Protein

RCC1 and BTB domain-containing protein 2

Gene

Rcbtb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RCC1 and BTB domain-containing protein 2
Alternative name(s):
Chromosome condensation 1-like
Regulator of chromosome condensation and BTB domain-containing protein 2
Gene namesi
Name:Rcbtb2
Synonyms:Chc1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1917200 Rcbtb2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066451 – 551RCC1 and BTB domain-containing protein 2Add BLAST551

Proteomic databases

PaxDbiQ99LJ7
PeptideAtlasiQ99LJ7
PRIDEiQ99LJ7

PTM databases

iPTMnetiQ99LJ7
PhosphoSitePlusiQ99LJ7

Expressioni

Tissue specificityi

Expressed in testis and heart (at protein level).1 Publication

Developmental stagei

Expressed in testis from postnatal day 12 onwards, reaching maximal levels at postnatal day 30 (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000022106 Expressed in 265 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ99LJ7 baseline and differential
GenevisibleiQ99LJ7 MM

Interactioni

Protein-protein interaction databases

BioGridi222895, 1 interactor
STRINGi10090.ENSMUSP00000022702

Structurei

3D structure databases

ProteinModelPortaliQ99LJ7
SMRiQ99LJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 115RCC1 1Sequence analysisAdd BLAST52
Repeati117 – 169RCC1 2Sequence analysisAdd BLAST53
Repeati171 – 222RCC1 3Sequence analysisAdd BLAST52
Repeati223 – 274RCC1 4Sequence analysisAdd BLAST52
Repeati276 – 326RCC1 5Sequence analysisAdd BLAST51
Repeati328 – 382RCC1 6Sequence analysisAdd BLAST55
Domaini394 – 457BTBPROSITE-ProRule annotationAdd BLAST64

Domaini

The BTB domain might play a role in targeting to acrosomal vesicles.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1426 Eukaryota
COG5184 LUCA
GeneTreeiENSGT00910000144029
HOGENOMiHOG000065752
HOVERGENiHBG053261
InParanoidiQ99LJ7
KOiK11494
OMAiALGTNCS
OrthoDBiEOG091G043O
PhylomeDBiQ99LJ7
TreeFamiTF329478

Family and domain databases

Gene3Di2.130.10.30, 2 hits
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00415 RCC1, 4 hits
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF50985 SSF50985, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00626 RCC1_2, 1 hit
PS50012 RCC1_3, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99LJ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEEVPGFYG ESGKSVQATL SSLKMLDVGK WPIFSLCSEE ELQLIRQACV
60 70 80 90 100
FGSAGNEVLY TTVNDEIFVL GTNCSGCLGV GDIQSTIEPR RLDSLTGKKI
110 120 130 140 150
ASLSYGSGPH IVLATTDGEV FTWGHNAYSQ LGNGTTNHGL VPCHISTNLS
160 170 180 190 200
NKQVIEVACG SYHSLVLTSD GEVFAWGYNN SGQVGSGSTA NQPIPRRVTG
210 220 230 240 250
CLQNKVVMNI ACGQMCSMAV VDTGEVYVWG YNGNGQLGLG SSGNQPTPCR
260 270 280 290 300
VAALQGIRVQ RVACGYAHTL VLTDEGQIYA WGANSYGQLG TGNKSNQSYP
310 320 330 340 350
TPVVVEKDRI IEIAACHSAH TSAAKTQGGH VYMWGQCRGQ SVILPHHTHF
360 370 380 390 400
CCTDDVFACF ATPAVTWRLL SVEPDDHLTV AESLKREFDN PDTADLKFLV
410 420 430 440 450
DGKYIYAHKV LLKIRCEHFR SSLEDSEDDI VEMSEFSYPV FRAFLEYLYT
460 470 480 490 500
DNISLSPEEA VGLLDLATFY SETRLKKLCQ QTIKQGICEE NAIALLSAAV
510 520 530 540 550
KYDAQDLEEF CFRFCINHLT VVTQTSGFAE MDHDLLKNFI SKASRVGAFK

N
Length:551
Mass (Da):60,164
Last modified:June 1, 2001 - v1
Checksum:i6D54A19067688609
GO
Isoform 2 (identifier: Q99LJ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Note: No experimental confirmation available.
Show »
Length:527
Mass (Da):57,608
Checksum:iDE8B721290A36F38
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q3B1E9Q3B1_MOUSE
RCC1 and BTB domain-containing prot...
Rcbtb2
517Annotation score:
E9Q3W8E9Q3W8_MOUSE
RCC1 and BTB domain-containing prot...
Rcbtb2
157Annotation score:
F6ZTZ2F6ZTZ2_MOUSE
RCC1 and BTB domain-containing prot...
Rcbtb2
292Annotation score:
E9Q7J4E9Q7J4_MOUSE
RCC1 and BTB domain-containing prot...
Rcbtb2
172Annotation score:
E9QA48E9QA48_MOUSE
RCC1 and BTB domain-containing prot...
Rcbtb2
149Annotation score:
E9QA84E9QA84_MOUSE
RCC1 and BTB domain-containing prot...
Rcbtb2
90Annotation score:
F6X7I4F6X7I4_MOUSE
RCC1 and BTB domain-containing prot...
Rcbtb2
219Annotation score:
F6QHR6F6QHR6_MOUSE
RCC1 and BTB domain-containing prot...
Rcbtb2
119Annotation score:
E9QAL7E9QAL7_MOUSE
RCC1 and BTB domain-containing prot...
Rcbtb2
128Annotation score:
E9PZR2E9PZR2_MOUSE
RCC1 and BTB domain-containing prot...
Rcbtb2
86Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211A → S in BAC27316 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0167241 – 24Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN086338 mRNA Translation: AEK06433.1
JN086339 mRNA Translation: AEK06434.1
AK031242 mRNA Translation: BAC27316.1
AK031248 mRNA Translation: BAC27319.1
AK160881 mRNA Translation: BAE36068.1
CT571265 Genomic DNA No translation available.
CH466535 Genomic DNA Translation: EDL35861.1
BC003224 mRNA Translation: AAH03224.1
CCDSiCCDS27266.1 [Q99LJ7-1]
RefSeqiNP_001164165.1, NM_001170694.1 [Q99LJ7-1]
NP_598844.3, NM_134083.4 [Q99LJ7-1]
XP_006518445.1, XM_006518382.3 [Q99LJ7-1]
XP_006518446.1, XM_006518383.2 [Q99LJ7-1]
XP_006518447.1, XM_006518384.1 [Q99LJ7-1]
XP_006518448.1, XM_006518385.3 [Q99LJ7-1]
XP_006518449.1, XM_006518386.2 [Q99LJ7-2]
XP_011243193.1, XM_011244891.2 [Q99LJ7-1]
UniGeneiMm.280068

Genome annotation databases

EnsembliENSMUST00000022702; ENSMUSP00000022702; ENSMUSG00000022106 [Q99LJ7-1]
ENSMUST00000110952; ENSMUSP00000106577; ENSMUSG00000022106 [Q99LJ7-1]
ENSMUST00000164822; ENSMUSP00000131588; ENSMUSG00000022106 [Q99LJ7-1]
ENSMUST00000169479; ENSMUSP00000126898; ENSMUSG00000022106 [Q99LJ7-1]
ENSMUST00000169513; ENSMUSP00000128579; ENSMUSG00000022106 [Q99LJ7-2]
ENSMUST00000170677; ENSMUSP00000126510; ENSMUSG00000022106 [Q99LJ7-2]
GeneIDi105670
KEGGimmu:105670
UCSCiuc007upj.2 mouse [Q99LJ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN086338 mRNA Translation: AEK06433.1
JN086339 mRNA Translation: AEK06434.1
AK031242 mRNA Translation: BAC27316.1
AK031248 mRNA Translation: BAC27319.1
AK160881 mRNA Translation: BAE36068.1
CT571265 Genomic DNA No translation available.
CH466535 Genomic DNA Translation: EDL35861.1
BC003224 mRNA Translation: AAH03224.1
CCDSiCCDS27266.1 [Q99LJ7-1]
RefSeqiNP_001164165.1, NM_001170694.1 [Q99LJ7-1]
NP_598844.3, NM_134083.4 [Q99LJ7-1]
XP_006518445.1, XM_006518382.3 [Q99LJ7-1]
XP_006518446.1, XM_006518383.2 [Q99LJ7-1]
XP_006518447.1, XM_006518384.1 [Q99LJ7-1]
XP_006518448.1, XM_006518385.3 [Q99LJ7-1]
XP_006518449.1, XM_006518386.2 [Q99LJ7-2]
XP_011243193.1, XM_011244891.2 [Q99LJ7-1]
UniGeneiMm.280068

3D structure databases

ProteinModelPortaliQ99LJ7
SMRiQ99LJ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222895, 1 interactor
STRINGi10090.ENSMUSP00000022702

PTM databases

iPTMnetiQ99LJ7
PhosphoSitePlusiQ99LJ7

Proteomic databases

PaxDbiQ99LJ7
PeptideAtlasiQ99LJ7
PRIDEiQ99LJ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022702; ENSMUSP00000022702; ENSMUSG00000022106 [Q99LJ7-1]
ENSMUST00000110952; ENSMUSP00000106577; ENSMUSG00000022106 [Q99LJ7-1]
ENSMUST00000164822; ENSMUSP00000131588; ENSMUSG00000022106 [Q99LJ7-1]
ENSMUST00000169479; ENSMUSP00000126898; ENSMUSG00000022106 [Q99LJ7-1]
ENSMUST00000169513; ENSMUSP00000128579; ENSMUSG00000022106 [Q99LJ7-2]
ENSMUST00000170677; ENSMUSP00000126510; ENSMUSG00000022106 [Q99LJ7-2]
GeneIDi105670
KEGGimmu:105670
UCSCiuc007upj.2 mouse [Q99LJ7-1]

Organism-specific databases

CTDi1102
MGIiMGI:1917200 Rcbtb2

Phylogenomic databases

eggNOGiKOG1426 Eukaryota
COG5184 LUCA
GeneTreeiENSGT00910000144029
HOGENOMiHOG000065752
HOVERGENiHBG053261
InParanoidiQ99LJ7
KOiK11494
OMAiALGTNCS
OrthoDBiEOG091G043O
PhylomeDBiQ99LJ7
TreeFamiTF329478

Miscellaneous databases

ChiTaRSiRcbtb2 mouse
PROiPR:Q99LJ7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022106 Expressed in 265 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ99LJ7 baseline and differential
GenevisibleiQ99LJ7 MM

Family and domain databases

Gene3Di2.130.10.30, 2 hits
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00415 RCC1, 4 hits
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF50985 SSF50985, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00626 RCC1_2, 1 hit
PS50012 RCC1_3, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRCBT2_MOUSE
AccessioniPrimary (citable) accession number: Q99LJ7
Secondary accession number(s): G1EE51, Q3TUA3, Q8BMG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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