UniProtKB - Q99LJ6 (GPX7_MOUSE)
Protein
Glutathione peroxidase 7
Gene
Gpx7
Organism
Mus musculus (Mouse)
Status
Functioni
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks (By similarity).By similarity
Catalytic activityi
- EC:1.11.1.9
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 56 | By similarity | 1 |
GO - Molecular functioni
- catalase activity Source: MGI
- glutathione peroxidase activity Source: UniProtKB-EC
- peroxidase activity Source: MGI
GO - Biological processi
- response to oxidative stress Source: InterPro
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Enzyme and pathway databases
Reactomei | R-MMU-3299685, Detoxification of Reactive Oxygen Species |
Protein family/group databases
PeroxiBasei | 3720, MmGPx07 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Gpx7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914555, Gpx7 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000013085 | 19 – 186 | Glutathione peroxidase 7Add BLAST | 168 |
Proteomic databases
MaxQBi | Q99LJ6 |
PaxDbi | Q99LJ6 |
PRIDEi | Q99LJ6 |
PTM databases
PhosphoSitePlusi | Q99LJ6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028597, Expressed in vault of skull and 297 other tissues |
ExpressionAtlasi | Q99LJ6, baseline and differential |
Genevisiblei | Q99LJ6, MM |
Interactioni
Protein-protein interaction databases
IntActi | Q99LJ6, 1 interactor |
MINTi | Q99LJ6 |
STRINGi | 10090.ENSMUSP00000030332 |
Miscellaneous databases
RNActi | Q99LJ6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the glutathione peroxidase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1651, Eukaryota |
GeneTreei | ENSGT00940000159127 |
HOGENOMi | CLU_029507_0_1_1 |
InParanoidi | Q99LJ6 |
OMAi | LAPFKGQ |
OrthoDBi | 1483113at2759 |
PhylomeDBi | Q99LJ6 |
TreeFami | TF331942 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR013376, Glut_perox_Gpx7 IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR02540, gpx7, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q99LJ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVAAVATAWL LLWAAACAQS EQDFYDFKAV NIRGKLVSLE KYRGSVSLVV
60 70 80 90 100
NVASECGFTD QNYRALQQLQ RDLGPHHFNV LAFPCNQFGQ QEPDTNREIE
110 120 130 140 150
NFARRTYSVS FPMFSKIAVT GTGAHPAFKY LTQTSGKEPT WNFWKYLVDP
160 170 180
DGKVVGAWDP TVPVAEIKPR ITEQVMKLIL RKREDL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketV9GXV4 | V9GXV4_MOUSE | Glutathione peroxidase 7 | Gpx7 | 59 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC003228 mRNA Translation: AAH03228.1 |
CCDSi | CCDS18450.1 |
RefSeqi | NP_077160.1, NM_024198.3 |
Genome annotation databases
Ensembli | ENSMUST00000030332; ENSMUSP00000030332; ENSMUSG00000028597 |
GeneIDi | 67305 |
KEGGi | mmu:67305 |
UCSCi | uc008ubc.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC003228 mRNA Translation: AAH03228.1 |
CCDSi | CCDS18450.1 |
RefSeqi | NP_077160.1, NM_024198.3 |
3D structure databases
SMRi | Q99LJ6 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q99LJ6, 1 interactor |
MINTi | Q99LJ6 |
STRINGi | 10090.ENSMUSP00000030332 |
Protein family/group databases
PeroxiBasei | 3720, MmGPx07 |
PTM databases
PhosphoSitePlusi | Q99LJ6 |
Proteomic databases
MaxQBi | Q99LJ6 |
PaxDbi | Q99LJ6 |
PRIDEi | Q99LJ6 |
Protocols and materials databases
Antibodypediai | 19147, 220 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000030332; ENSMUSP00000030332; ENSMUSG00000028597 |
GeneIDi | 67305 |
KEGGi | mmu:67305 |
UCSCi | uc008ubc.1, mouse |
Organism-specific databases
CTDi | 2882 |
MGIi | MGI:1914555, Gpx7 |
Phylogenomic databases
eggNOGi | KOG1651, Eukaryota |
GeneTreei | ENSGT00940000159127 |
HOGENOMi | CLU_029507_0_1_1 |
InParanoidi | Q99LJ6 |
OMAi | LAPFKGQ |
OrthoDBi | 1483113at2759 |
PhylomeDBi | Q99LJ6 |
TreeFami | TF331942 |
Enzyme and pathway databases
Reactomei | R-MMU-3299685, Detoxification of Reactive Oxygen Species |
Miscellaneous databases
BioGRID-ORCSi | 67305, 0 hits in 17 CRISPR screens |
ChiTaRSi | Gpx7, mouse |
PROi | PR:Q99LJ6 |
RNActi | Q99LJ6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028597, Expressed in vault of skull and 297 other tissues |
ExpressionAtlasi | Q99LJ6, baseline and differential |
Genevisiblei | Q99LJ6, MM |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR013376, Glut_perox_Gpx7 IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR02540, gpx7, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPX7_MOUSE | |
Accessioni | Q99LJ6Primary (citable) accession number: Q99LJ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 4, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families