UniProtKB - Q99LJ5 (CKLF3_MOUSE)
Protein
CKLF-like MARVEL transmembrane domain-containing protein 3
Gene
Cmtm3
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
GO - Biological processi
- blastocyst hatching Source: MGI
- chemotaxis Source: UniProtKB-KW
- positive regulation of B cell receptor signaling pathway Source: MGI
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis |
Names & Taxonomyi
Protein namesi | Recommended name: CKLF-like MARVEL transmembrane domain-containing protein 3Alternative name(s): Chemokine-like factor superfamily member 3 |
Gene namesi | Name:Cmtm3 Synonyms:Cklfsf3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2447162, Cmtm3 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: MGI
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Nucleus
- nuclear membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- cytoplasmic vesicle Source: MGI
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 96 – 116 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186102 | 1 – 184 | CKLF-like MARVEL transmembrane domain-containing protein 3Add BLAST | 184 |
Proteomic databases
MaxQBi | Q99LJ5 |
PaxDbi | Q99LJ5 |
PRIDEi | Q99LJ5 |
PTM databases
iPTMneti | Q99LJ5 |
PhosphoSitePlusi | Q99LJ5 |
SwissPalmi | Q99LJ5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031875, Expressed in decidua and 269 other tissues |
ExpressionAtlasi | Q99LJ5, baseline and differential |
Genevisiblei | Q99LJ5, MM |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 212666, 2 interactors |
CORUMi | Q99LJ5 |
STRINGi | 10090.ENSMUSP00000034343 |
Miscellaneous databases
RNActi | Q99LJ5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 155 | MARVELPROSITE-ProRule annotationAdd BLAST | 120 |
Sequence similaritiesi
Belongs to the chemokine-like factor family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4788, Eukaryota |
GeneTreei | ENSGT00940000160432 |
HOGENOMi | CLU_108546_1_0_1 |
InParanoidi | Q99LJ5 |
OrthoDBi | 1578763at2759 |
PhylomeDBi | Q99LJ5 |
TreeFami | TF317387 |
Family and domain databases
InterProi | View protein in InterPro IPR008253, Marvel |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q99LJ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWPPDAEPEP DPESAHGPRS GRTVPGLRAL LPARAFLCSL KGRLLLAESG
60 70 80 90 100
LSFITFICYV VSSASAFLTV PLLEFLLAVY FLFADAMQLN DKWQGLCWPM
110 120 130 140 150
MDFLRCVTAA LIYFVISITA VAKYSDGAYK AAGVFGFFAT IVFAIDFYLI
160 170 180
FNEVAKFLKQ GDSGNETTAH RTEEENSNSD SDSD
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1D5RLE8 | A0A1D5RLE8_MOUSE | CKLF-like MARVEL transmembrane doma... | Cmtm3 | 118 | Annotation score: | ||
A0A1D5RM50 | A0A1D5RM50_MOUSE | CKLF-like MARVEL transmembrane doma... | Cmtm3 | 142 | Annotation score: | ||
A0A1D5RLU9 | A0A1D5RLU9_MOUSE | CKLF-like MARVEL transmembrane doma... | Cmtm3 | 82 | Annotation score: |
Sequence cautioni
The sequence BAB23056 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 146 | D → G in BAC37565 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY241870 mRNA Translation: AAP33492.1 AK003882 mRNA Translation: BAB23056.1 Frameshift. AK079165 mRNA Translation: BAC37565.1 BC003230 mRNA Translation: AAH03230.1 BC145817 mRNA Translation: AAI45818.1 BC145819 mRNA Translation: AAI45820.1 |
CCDSi | CCDS22577.1 |
RefSeqi | NP_077179.1, NM_024217.3 XP_006531389.1, XM_006531326.1 XP_006531390.1, XM_006531327.2 XP_006531391.1, XM_006531328.1 XP_006531392.1, XM_006531329.2 |
Genome annotation databases
Ensembli | ENSMUST00000034343; ENSMUSP00000034343; ENSMUSG00000031875 ENSMUST00000212081; ENSMUSP00000148682; ENSMUSG00000031875 |
GeneIDi | 68119 |
KEGGi | mmu:68119 |
UCSCi | uc009nam.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY241870 mRNA Translation: AAP33492.1 AK003882 mRNA Translation: BAB23056.1 Frameshift. AK079165 mRNA Translation: BAC37565.1 BC003230 mRNA Translation: AAH03230.1 BC145817 mRNA Translation: AAI45818.1 BC145819 mRNA Translation: AAI45820.1 |
CCDSi | CCDS22577.1 |
RefSeqi | NP_077179.1, NM_024217.3 XP_006531389.1, XM_006531326.1 XP_006531390.1, XM_006531327.2 XP_006531391.1, XM_006531328.1 XP_006531392.1, XM_006531329.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 212666, 2 interactors |
CORUMi | Q99LJ5 |
STRINGi | 10090.ENSMUSP00000034343 |
PTM databases
iPTMneti | Q99LJ5 |
PhosphoSitePlusi | Q99LJ5 |
SwissPalmi | Q99LJ5 |
Proteomic databases
MaxQBi | Q99LJ5 |
PaxDbi | Q99LJ5 |
PRIDEi | Q99LJ5 |
Protocols and materials databases
Antibodypediai | 2892, 127 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034343; ENSMUSP00000034343; ENSMUSG00000031875 ENSMUST00000212081; ENSMUSP00000148682; ENSMUSG00000031875 |
GeneIDi | 68119 |
KEGGi | mmu:68119 |
UCSCi | uc009nam.1, mouse |
Organism-specific databases
CTDi | 123920 |
MGIi | MGI:2447162, Cmtm3 |
Phylogenomic databases
eggNOGi | KOG4788, Eukaryota |
GeneTreei | ENSGT00940000160432 |
HOGENOMi | CLU_108546_1_0_1 |
InParanoidi | Q99LJ5 |
OrthoDBi | 1578763at2759 |
PhylomeDBi | Q99LJ5 |
TreeFami | TF317387 |
Miscellaneous databases
BioGRID-ORCSi | 68119, 2 hits in 17 CRISPR screens |
PROi | PR:Q99LJ5 |
RNActi | Q99LJ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031875, Expressed in decidua and 269 other tissues |
ExpressionAtlasi | Q99LJ5, baseline and differential |
Genevisiblei | Q99LJ5, MM |
Family and domain databases
InterProi | View protein in InterPro IPR008253, Marvel |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CKLF3_MOUSE | |
Accessioni | Q99LJ5Primary (citable) accession number: Q99LJ5 Secondary accession number(s): A6H6B5, Q8BJU1, Q9D165 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families