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Protein

CKLF-like MARVEL transmembrane domain-containing protein 3

Gene

Cmtm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • blastocyst hatching Source: MGI
  • chemotaxis Source: UniProtKB-KW
  • positive regulation of B cell receptor signaling pathway Source: MGI

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 3
Alternative name(s):
Chemokine-like factor superfamily member 3
Gene namesi
Name:Cmtm3
Synonyms:Cklfsf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2447162 Cmtm3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861021 – 184CKLF-like MARVEL transmembrane domain-containing protein 3Add BLAST184

Proteomic databases

MaxQBiQ99LJ5
PaxDbiQ99LJ5
PRIDEiQ99LJ5

PTM databases

iPTMnetiQ99LJ5
PhosphoSitePlusiQ99LJ5
SwissPalmiQ99LJ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000031875 Expressed in 251 organ(s), highest expression level in decidua
ExpressionAtlasiQ99LJ5 baseline and differential
GenevisibleiQ99LJ5 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212666, 1 interactor
CORUMiQ99LJ5
STRINGi10090.ENSMUSP00000034343

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 155MARVELPROSITE-ProRule annotationAdd BLAST120

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00530000063326
HOGENOMiHOG000290654
HOVERGENiHBG053619
InParanoidiQ99LJ5
OrthoDBiEOG091G11FO
PhylomeDBiQ99LJ5
TreeFamiTF317387

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99LJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPPDAEPEP DPESAHGPRS GRTVPGLRAL LPARAFLCSL KGRLLLAESG
60 70 80 90 100
LSFITFICYV VSSASAFLTV PLLEFLLAVY FLFADAMQLN DKWQGLCWPM
110 120 130 140 150
MDFLRCVTAA LIYFVISITA VAKYSDGAYK AAGVFGFFAT IVFAIDFYLI
160 170 180
FNEVAKFLKQ GDSGNETTAH RTEEENSNSD SDSD
Length:184
Mass (Da):20,247
Last modified:June 1, 2001 - v1
Checksum:i6FBB899137D51EB3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RM50A0A1D5RM50_MOUSE
CKLF-like MARVEL transmembrane doma...
Cmtm3
142Annotation score:
A0A1D5RLE8A0A1D5RLE8_MOUSE
CKLF-like MARVEL transmembrane doma...
Cmtm3
118Annotation score:
A0A1D5RLU9A0A1D5RLU9_MOUSE
CKLF-like MARVEL transmembrane doma...
Cmtm3
82Annotation score:

Sequence cautioni

The sequence BAB23056 differs from that shown. Reason: Frameshift at position 137.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146D → G in BAC37565 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY241870 mRNA Translation: AAP33492.1
AK003882 mRNA Translation: BAB23056.1 Frameshift.
AK079165 mRNA Translation: BAC37565.1
BC003230 mRNA Translation: AAH03230.1
BC145817 mRNA Translation: AAI45818.1
BC145819 mRNA Translation: AAI45820.1
CCDSiCCDS22577.1
RefSeqiNP_077179.1, NM_024217.3
XP_006531389.1, XM_006531326.1
XP_006531390.1, XM_006531327.2
XP_006531391.1, XM_006531328.1
XP_006531392.1, XM_006531329.2
UniGeneiMm.390108

Genome annotation databases

EnsembliENSMUST00000034343; ENSMUSP00000034343; ENSMUSG00000031875
ENSMUST00000212081; ENSMUSP00000148682; ENSMUSG00000031875
GeneIDi68119
KEGGimmu:68119
UCSCiuc009nam.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY241870 mRNA Translation: AAP33492.1
AK003882 mRNA Translation: BAB23056.1 Frameshift.
AK079165 mRNA Translation: BAC37565.1
BC003230 mRNA Translation: AAH03230.1
BC145817 mRNA Translation: AAI45818.1
BC145819 mRNA Translation: AAI45820.1
CCDSiCCDS22577.1
RefSeqiNP_077179.1, NM_024217.3
XP_006531389.1, XM_006531326.1
XP_006531390.1, XM_006531327.2
XP_006531391.1, XM_006531328.1
XP_006531392.1, XM_006531329.2
UniGeneiMm.390108

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212666, 1 interactor
CORUMiQ99LJ5
STRINGi10090.ENSMUSP00000034343

PTM databases

iPTMnetiQ99LJ5
PhosphoSitePlusiQ99LJ5
SwissPalmiQ99LJ5

Proteomic databases

MaxQBiQ99LJ5
PaxDbiQ99LJ5
PRIDEiQ99LJ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034343; ENSMUSP00000034343; ENSMUSG00000031875
ENSMUST00000212081; ENSMUSP00000148682; ENSMUSG00000031875
GeneIDi68119
KEGGimmu:68119
UCSCiuc009nam.1 mouse

Organism-specific databases

CTDi123920
MGIiMGI:2447162 Cmtm3

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00530000063326
HOGENOMiHOG000290654
HOVERGENiHBG053619
InParanoidiQ99LJ5
OrthoDBiEOG091G11FO
PhylomeDBiQ99LJ5
TreeFamiTF317387

Miscellaneous databases

PROiPR:Q99LJ5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031875 Expressed in 251 organ(s), highest expression level in decidua
ExpressionAtlasiQ99LJ5 baseline and differential
GenevisibleiQ99LJ5 MM

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCKLF3_MOUSE
AccessioniPrimary (citable) accession number: Q99LJ5
Secondary accession number(s): A6H6B5, Q8BJU1, Q9D165
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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