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Protein

Ankyrin repeat and BTB/POZ domain-containing protein 1

Gene

Abtb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and BTB/POZ domain-containing protein 1
Gene namesi
Name:Abtb1Imported
Synonyms:Bpoz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1933148 Abtb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002482681 – 478Ankyrin repeat and BTB/POZ domain-containing protein 1Add BLAST478

Proteomic databases

PaxDbiQ99LJ2
PRIDEiQ99LJ2

PTM databases

iPTMnetiQ99LJ2
PhosphoSitePlusiQ99LJ2

Interactioni

Protein-protein interaction databases

BioGridi219771, 3 interactors
STRINGi10090.ENSMUSP00000032169

Structurei

3D structure databases

ProteinModelPortaliQ99LJ2
SMRiQ99LJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 31ANK 1Sequence analysisAdd BLAST31
Repeati35 – 64ANK 2Sequence analysisAdd BLAST30
Domaini115 – 182BTB 1PROSITE-ProRule annotationAdd BLAST68
Domaini272 – 346BTB 2PROSITE-ProRule annotationAdd BLAST75

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili451 – 477Sequence analysisAdd BLAST27

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0511 Eukaryota
COG0666 LUCA
HOGENOMiHOG000253956
HOVERGENiHBG059559
InParanoidiQ99LJ2
KOiK10520
PhylomeDBiQ99LJ2
TreeFamiTF329194

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00651 BTB, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00225 BTB, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50097 BTB, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q99LJ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTSDLFASC RKGDVGRVRY LLEQRDVEVN VRDKWDSTPL YYACLCGHEE
60 70 80 90 100
LVRYLLANGA RCEANTFDGE RCLYGALSDP IRRALRDYKQ VTASCRRRDY
110 120 130 140 150
YDDFLQRLLE QGIHSDVVFV VHGKPFRAHR CILGARSTYF ANMLDTKWKG
160 170 180 190 200
KSVVVLRHPL INPVAFGALL QYLYTGRLDI GVEHVSDCER LAKQCQLWDL
210 220 230 240 250
LDDLEAKCEK VSEFVASKPG TCVKVLTIEP PPADPRLRAD MALLADCALP
260 270 280 290 300
SELRGDLGEL PFPCPDGFSS CPDICFRVAD SSFLCHKAFF CGRSDYFRAL
310 320 330 340 350
LDDHFQESEE PAASGDPPVV TLHDISPDIF IHVLYYVYSD HTELPPELAY
360 370 380 390 400
DVLSVADMYL LPGLKRLCGR SLAQLLEEDS VVGVWRIAKM FRLARLEDQC
410 420 430 440 450
TEYMAKVIEK LVEREDFVEA VREEAAAVAA RQETDSIPLV DDIRFHVAST
460 470
VQTYSAIEEA QQRLRALEDL LVSIGLDC
Length:478
Mass (Da):54,058
Last modified:June 1, 2001 - v1
Checksum:i65AAB8C27E179553
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0A1A0A0R4J0A1_MOUSE
Ankyrin repeat and BTB/POZ domain-c...
Abtb1
478Annotation score:
A0A0N4SVK7A0A0N4SVK7_MOUSE
Ankyrin repeat and BTB (POZ) domain...
Abtb1 mCG_130616
40Annotation score:
A0A0N4SVV0A0A0N4SVV0_MOUSE
Ankyrin repeat and BTB/POZ domain-c...
Abtb1
43Annotation score:
A0A0N4SV19A0A0N4SV19_MOUSE
Ankyrin repeat and BTB/POZ domain-c...
Abtb1
47Annotation score:
A0A0N4SUP1A0A0N4SUP1_MOUSE
Ankyrin repeat and BTB (POZ) domain...
Abtb1 mCG_130616
36Annotation score:
A0A0N4SVH8A0A0N4SVH8_MOUSE
Ankyrin repeat and BTB/POZ domain-c...
Abtb1
22Annotation score:
A0A0N4SW21A0A0N4SW21_MOUSE
Ankyrin repeat and BTB/POZ domain-c...
Abtb1
16Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92T → A in BAC40352 (PubMed:16141072).Curated1
Sequence conflicti286H → Y in BAB55652 (PubMed:11494141).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053477 mRNA Translation: BAB55652.1
AK088437 mRNA Translation: BAC40352.1
BC003234 mRNA Translation: AAH03234.1
CCDSiCCDS20339.1
RefSeqiNP_084527.2, NM_030251.3
UniGeneiMm.166858

Genome annotation databases

GeneIDi80283
KEGGimmu:80283
UCSCiuc009cvs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053477 mRNA Translation: BAB55652.1
AK088437 mRNA Translation: BAC40352.1
BC003234 mRNA Translation: AAH03234.1
CCDSiCCDS20339.1
RefSeqiNP_084527.2, NM_030251.3
UniGeneiMm.166858

3D structure databases

ProteinModelPortaliQ99LJ2
SMRiQ99LJ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219771, 3 interactors
STRINGi10090.ENSMUSP00000032169

PTM databases

iPTMnetiQ99LJ2
PhosphoSitePlusiQ99LJ2

Proteomic databases

PaxDbiQ99LJ2
PRIDEiQ99LJ2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi80283
KEGGimmu:80283
UCSCiuc009cvs.2 mouse

Organism-specific databases

CTDi80325
MGIiMGI:1933148 Abtb1

Phylogenomic databases

eggNOGiKOG0511 Eukaryota
COG0666 LUCA
HOGENOMiHOG000253956
HOVERGENiHBG059559
InParanoidiQ99LJ2
KOiK10520
PhylomeDBiQ99LJ2
TreeFamiTF329194

Miscellaneous databases

PROiPR:Q99LJ2
SOURCEiSearch...

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00651 BTB, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00225 BTB, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50097 BTB, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiABTB1_MOUSE
AccessioniPrimary (citable) accession number: Q99LJ2
Secondary accession number(s): Q8C2K7, Q91XU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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