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Protein

CTTNBP2 N-terminal-like protein

Gene

Cttnbp2nl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CTTNBP2 N-terminal-like protein
Gene namesi
Name:Cttnbp2nl
Synonyms:Kiaa1433
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1933137 Cttnbp2nl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002269981 – 638CTTNBP2 N-terminal-like proteinAdd BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285PhosphoserineBy similarity1
Modified residuei481PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1
Modified residuei522PhosphoserineBy similarity1
Modified residuei526PhosphoserineBy similarity1
Modified residuei559PhosphoserineBy similarity1
Modified residuei562PhosphoserineBy similarity1
Modified residuei567PhosphoserineBy similarity1
Modified residuei569PhosphothreonineBy similarity1
Modified residuei589PhosphothreonineBy similarity1
Modified residuei591PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99LJ0
PaxDbiQ99LJ0
PeptideAtlasiQ99LJ0
PRIDEiQ99LJ0

PTM databases

iPTMnetiQ99LJ0
PhosphoSitePlusiQ99LJ0

Expressioni

Tissue specificityi

Predominantly expressed in skin, also detectable in spleen and lung (at protein level). Very low levels, if any, in brain (at protein level).

Gene expression databases

BgeeiENSMUSG00000062127 Expressed in 270 organ(s), highest expression level in brain blood vessel
CleanExiMM_CTTNBP2NL
ExpressionAtlasiQ99LJ0 baseline and differential
GenevisibleiQ99LJ0 MM

Interactioni

Subunit structurei

May form homomers (By similarity). May interact with MOB4, PPP2R1A, PPP2CB, STK24, STK25, STK26, STRN4, STRIP1 and STRIP2 (By similarity). Interacts with CTTN/cortactin; this interaction may redistribute CTTN to stress fibers.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219770, 1 interactor
STRINGi10090.ENSMUSP00000076751

Structurei

3D structure databases

ProteinModelPortaliQ99LJ0
SMRiQ99LJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 284Sequence analysisAdd BLAST198

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1103 Eukaryota
ENOG410YR8R LUCA
GeneTreeiENSGT00930000150884
HOGENOMiHOG000112036
HOVERGENiHBG081371
InParanoidiQ99LJ0
OMAiYQAGINQ
OrthoDBiEOG091G0CSA
PhylomeDBiQ99LJ0
TreeFamiTF325130

Family and domain databases

InterProiView protein in InterPro
IPR019131 Cortactin-binding_p2_N
PfamiView protein in Pfam
PF09727 CortBP2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99LJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLEKLSKPE LLTLFSILEG ELEARDLVIE ALKAQHRDTF IEERYGKYNI
60 70 80 90 100
SDPLMALQRD FETLKEKNDS EKQPVCTNPL SVLKAVMKQC KNMQERMLSQ
110 120 130 140 150
LAAAESRHRK VILDLEEERQ RHAQDTAEGD DVTYMLEKER ERLTQQLEFE
160 170 180 190 200
KSQVKKFEKE QKKLSSQLEE ERTRHKQLSS MLVLECRKAT SKAAEEGQKA
210 220 230 240 250
GELSLKLDKE KSRASKLEEE LAAERKRGLQ TEAQVEKQLS EFDIEREQLR
260 270 280 290 300
AKLNREENRT RALKEEVESL KKLVKDLEAA QQHRSTSEQG REPVTMSRGT
310 320 330 340 350
ATEPPMRVSA FCQTESVQTE RSHGSVITKL TDTGLPGPTT AAYSYAKANG
360 370 380 390 400
HCDPEIQTTR ELTSDSSTEN QGPPREKSAV AAQEKPVENG GCPVGTETPV
410 420 430 440 450
TMPSHLPSSG SSLSPSSTAS SSLTSSPCSS PVLTKRLLGS AASSPGYQSS
460 470 480 490 500
YQVGINQRFH AARHKFQSQA DQDQQASGLQ SPPSRDLSPT LLDNSAAKQL
510 520 530 540 550
ARNTVTQVLS RFTNQGPIKP VSPNSSPFGT DYRNLASTAS PRGDTSHSPT
560 570 580 590 600
PGKVSSPLSP LSPGIKSPTI PRAERGNPPP IPPKKPGLTP SQSATTPVTK
610 620 630
THSQASSLAA TEDLASSCSP SAVVANGKDV EILLPTSS
Length:638
Mass (Da):69,841
Last modified:June 1, 2001 - v1
Checksum:i9E3CC4364E73972C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JFS0A0A0G2JFS0_MOUSE
CTTNBP2 N-terminal-like protein
Cttnbp2nl
167Annotation score:

Sequence cautioni

The sequence BAC98169 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92N → D in BAC26964 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129359 mRNA Translation: BAC98169.1 Different initiation.
AK029901 mRNA Translation: BAC26666.1
AK030438 mRNA Translation: BAC26964.1
BC003236 mRNA Translation: AAH03236.1
BC006952 mRNA Translation: AAH06952.1
CCDSiCCDS17707.1
RefSeqiNP_001156804.1, NM_001163332.1
NP_001156805.1, NM_001163333.1
NP_084525.1, NM_030249.4
XP_011238590.1, XM_011240288.2
UniGeneiMm.200327

Genome annotation databases

EnsembliENSMUST00000077548; ENSMUSP00000076751; ENSMUSG00000062127
ENSMUST00000098763; ENSMUSP00000096359; ENSMUSG00000062127
GeneIDi80281
KEGGimmu:80281
UCSCiuc008quv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129359 mRNA Translation: BAC98169.1 Different initiation.
AK029901 mRNA Translation: BAC26666.1
AK030438 mRNA Translation: BAC26964.1
BC003236 mRNA Translation: AAH03236.1
BC006952 mRNA Translation: AAH06952.1
CCDSiCCDS17707.1
RefSeqiNP_001156804.1, NM_001163332.1
NP_001156805.1, NM_001163333.1
NP_084525.1, NM_030249.4
XP_011238590.1, XM_011240288.2
UniGeneiMm.200327

3D structure databases

ProteinModelPortaliQ99LJ0
SMRiQ99LJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219770, 1 interactor
STRINGi10090.ENSMUSP00000076751

PTM databases

iPTMnetiQ99LJ0
PhosphoSitePlusiQ99LJ0

Proteomic databases

MaxQBiQ99LJ0
PaxDbiQ99LJ0
PeptideAtlasiQ99LJ0
PRIDEiQ99LJ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077548; ENSMUSP00000076751; ENSMUSG00000062127
ENSMUST00000098763; ENSMUSP00000096359; ENSMUSG00000062127
GeneIDi80281
KEGGimmu:80281
UCSCiuc008quv.2 mouse

Organism-specific databases

CTDi55917
MGIiMGI:1933137 Cttnbp2nl
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1103 Eukaryota
ENOG410YR8R LUCA
GeneTreeiENSGT00930000150884
HOGENOMiHOG000112036
HOVERGENiHBG081371
InParanoidiQ99LJ0
OMAiYQAGINQ
OrthoDBiEOG091G0CSA
PhylomeDBiQ99LJ0
TreeFamiTF325130

Miscellaneous databases

ChiTaRSiCttnbp2nl mouse
PROiPR:Q99LJ0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062127 Expressed in 270 organ(s), highest expression level in brain blood vessel
CleanExiMM_CTTNBP2NL
ExpressionAtlasiQ99LJ0 baseline and differential
GenevisibleiQ99LJ0 MM

Family and domain databases

InterProiView protein in InterPro
IPR019131 Cortactin-binding_p2_N
PfamiView protein in Pfam
PF09727 CortBP2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCT2NL_MOUSE
AccessioniPrimary (citable) accession number: Q99LJ0
Secondary accession number(s): Q6ZPR0, Q8BSV1, Q922L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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