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Protein

Cleavage stimulation factor subunit 3

Gene

Cstf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.By similarity

GO - Molecular functioni

  • mRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processmRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing
R-MMU-77595 Processing of Intronless Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage stimulation factor subunit 3
Alternative name(s):
CF-1 77 kDa subunit
Cleavage stimulation factor 77 kDa subunit
Short name:
CSTF 77 kDa subunit
Short name:
CstF-77
Gene namesi
Name:Cstf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1351825 Cstf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002057232 – 717Cleavage stimulation factor subunit 3Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei691PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99LI7
MaxQBiQ99LI7
PaxDbiQ99LI7
PeptideAtlasiQ99LI7
PRIDEiQ99LI7

PTM databases

iPTMnetiQ99LI7
PhosphoSitePlusiQ99LI7

Expressioni

Gene expression databases

BgeeiENSMUSG00000027176 Expressed in 283 organ(s), highest expression level in respiratory primordium
GenevisibleiQ99LI7 MM

Interactioni

Subunit structurei

Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi230731, 2 interactors
IntActiQ99LI7, 1 interactor
MINTiQ99LI7
STRINGi10090.ENSMUSP00000028599

Structurei

Secondary structure

1717
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99LI7
SMRiQ99LI7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99LI7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 77HAT 1Add BLAST33
Repeati79 – 110HAT 2Add BLAST32
Repeati117 – 152HAT 3Add BLAST36
Repeati163 – 196HAT 4Add BLAST34
Repeati221 – 261HAT 5Add BLAST41
Repeati271 – 303HAT 6Add BLAST33
Repeati319 – 352HAT 7Add BLAST34
Repeati354 – 387HAT 8Add BLAST34
Repeati458 – 494HAT 9Add BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi559 – 626Pro-richAdd BLAST68

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1914 Eukaryota
COG5107 LUCA
GeneTreeiENSGT00390000006758
HOGENOMiHOG000231786
HOVERGENiHBG053813
InParanoidiQ99LI7
KOiK14408
OMAiKSVDIWN
OrthoDBiEOG091G02LY
PhylomeDBiQ99LI7
TreeFamiTF105867

Family and domain databases

InterProiView protein in InterPro
IPR003107 HAT
IPR008847 Suf
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF05843 Suf, 1 hit
SMARTiView protein in SMART
SM00386 HAT, 10 hits
SUPFAMiSSF48452 SSF48452, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99LI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGDAAAEQA AEYVPEKVKK AEKKLEENPY DLDAWSILIR EAQNQPIDKA
60 70 80 90 100
RKTYERLVAQ FPSSGRFWKL YIEAEIKAKN YDKVEKLFQR CLMKVLHIDL
110 120 130 140 150
WKCYLSYVRE TKGKLPSYKE KMAQAYDFAL DKIGMEIMSY QIWVDYINFL
160 170 180 190 200
KGVEAVGSYA ENQRITAVRR VYQRGCVNPM INIEQLWRDY NKYEEGINIH
210 220 230 240 250
LAKKMIEDRS RDYMNARRVA KEYETVMKGL DRNAPSVPPQ NTPQEAQQVD
260 270 280 290 300
MWKKYIQWEK SNPLRTEDQT LITKRVMFAY EQCLLVLGHH PDIWYEAAQY
310 320 330 340 350
LEQSSKLLAE KGDMNNAKLF SDEAANIYER AISTLLKKNM LLYFAYADYE
360 370 380 390 400
ESRMKYEKVH SIYNRLLAIE DIDPTLVYIQ YMKFARRAEG IKSGRMIFKK
410 420 430 440 450
AREDARTRHH VYVTAALMEY YCSKDKSVAF KIFELGLKKY GDIPEYVLAY
460 470 480 490 500
IDYLSHLNED NNTRVLFERV LTSGSLPPEK SGEIWARFLA FESNIGDLAS
510 520 530 540 550
ILKVEKRRFT AFREEYEGKE TALLVDRYKF MDLYPCSASE LKALGYKDVS
560 570 580 590 600
RAKLAAIIPD PVVAPSIVPV LKDEVDRKPE YPKPDTQQMI PFQPRHLAPP
610 620 630 640 650
GLHPVPGGVF PVPPAAVVLM KLLPPPICFQ GPFVQVDELM EIFRRCKIPN
660 670 680 690 700
TVEEAVRIIT GGAPELAVEG NGPVESSAVL TKAVKRPNED SDEDEEKGAV
710
VPPVHDIYRA RQQKRIR
Length:717
Mass (Da):82,877
Last modified:June 1, 2001 - v1
Checksum:i40CF9CC39D496645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003241 mRNA Translation: AAH03241.1
CCDSiCCDS16490.1
RefSeqiNP_663504.1, NM_145529.3
UniGeneiMm.259876
Mm.479443

Genome annotation databases

EnsembliENSMUST00000028599; ENSMUSP00000028599; ENSMUSG00000027176
GeneIDi228410
KEGGimmu:228410
UCSCiuc008ljz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003241 mRNA Translation: AAH03241.1
CCDSiCCDS16490.1
RefSeqiNP_663504.1, NM_145529.3
UniGeneiMm.259876
Mm.479443

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ONDX-ray2.80A/B242-549[»]
2OOEX-ray3.00A21-549[»]
ProteinModelPortaliQ99LI7
SMRiQ99LI7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230731, 2 interactors
IntActiQ99LI7, 1 interactor
MINTiQ99LI7
STRINGi10090.ENSMUSP00000028599

PTM databases

iPTMnetiQ99LI7
PhosphoSitePlusiQ99LI7

Proteomic databases

EPDiQ99LI7
MaxQBiQ99LI7
PaxDbiQ99LI7
PeptideAtlasiQ99LI7
PRIDEiQ99LI7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028599; ENSMUSP00000028599; ENSMUSG00000027176
GeneIDi228410
KEGGimmu:228410
UCSCiuc008ljz.2 mouse

Organism-specific databases

CTDi1479
MGIiMGI:1351825 Cstf3

Phylogenomic databases

eggNOGiKOG1914 Eukaryota
COG5107 LUCA
GeneTreeiENSGT00390000006758
HOGENOMiHOG000231786
HOVERGENiHBG053813
InParanoidiQ99LI7
KOiK14408
OMAiKSVDIWN
OrthoDBiEOG091G02LY
PhylomeDBiQ99LI7
TreeFamiTF105867

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing
R-MMU-77595 Processing of Intronless Pre-mRNAs

Miscellaneous databases

ChiTaRSiCstf3 mouse
EvolutionaryTraceiQ99LI7
PROiPR:Q99LI7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027176 Expressed in 283 organ(s), highest expression level in respiratory primordium
GenevisibleiQ99LI7 MM

Family and domain databases

InterProiView protein in InterPro
IPR003107 HAT
IPR008847 Suf
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF05843 Suf, 1 hit
SMARTiView protein in SMART
SM00386 HAT, 10 hits
SUPFAMiSSF48452 SSF48452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSTF3_MOUSE
AccessioniPrimary (citable) accession number: Q99LI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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