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Protein

Chloride channel CLIC-like protein 1

Gene

Clcc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to act as a chloride ion channel.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel CLIC-like protein 1
Gene namesi
Name:Clcc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2385186 Clcc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000029768319 – 539Chloride channel CLIC-like protein 1Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei429PhosphoserineCombined sources1
Modified residuei433PhosphoserineBy similarity1
Modified residuei459PhosphoserineBy similarity1
Modified residuei476PhosphothreonineBy similarity1
Modified residuei498PhosphoserineCombined sources1
Modified residuei513PhosphoserineBy similarity1
Modified residuei521PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99LI2
MaxQBiQ99LI2
PaxDbiQ99LI2
PeptideAtlasiQ99LI2
PRIDEiQ99LI2

PTM databases

iPTMnetiQ99LI2
PhosphoSitePlusiQ99LI2
SwissPalmiQ99LI2

Expressioni

Gene expression databases

BgeeiENSMUSG00000027884 Expressed in 271 organ(s), highest expression level in primary oocyte
CleanExiMM_CLCC1
ExpressionAtlasiQ99LI2 baseline and differential
GenevisibleiQ99LI2 MM

Interactioni

Protein-protein interaction databases

IntActiQ99LI2, 2 interactors
STRINGi10090.ENSMUSP00000102224

Structurei

3D structure databases

ProteinModelPortaliQ99LI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chloride channel MCLC family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJAP Eukaryota
ENOG41108E0 LUCA
GeneTreeiENSGT00390000016611
HOGENOMiHOG000231351
HOVERGENiHBG060364
InParanoidiQ99LI2
KOiK22188

Family and domain databases

InterProiView protein in InterPro
IPR009231 Chloride_chnl_CLIC-like
PANTHERiPTHR34093 PTHR34093, 1 hit
PfamiView protein in Pfam
PF05934 MCLC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99LI2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCRLLLCEC LLLITGYAHD DDWIDPTDML NYDAASGTMR KSQVRSGTSE
60 70 80 90 100
KKEVSPDSSE AEELSDCLHR LDSLTHKVDS CEKKKMKDYE SQSNPVFRRY
110 120 130 140 150
LNKILIEAGK LGLPDENKVE MRYDAEILLS RQTLLEIQKF LSGEEWKPGA
160 170 180 190 200
LDDALSDILI NFKCHDSEAW KWQFEDYFGV DPYNVFMVLL CLLCLVVLVA
210 220 230 240 250
TELWTYVRWY TQMKRIFIIS FLLSLAWNWI YLYKMAFAQH QANIAGMEPF
260 270 280 290 300
DNLCAKKMDW TGSLWEWFTS SWTYKDDPCQ KYYELLIVNP IWLVPPTKAL
310 320 330 340 350
AITFTNFVTE PLKHIGKGAG EFIKALMKEI PVLLQIPVLA ILALAVLSFC
360 370 380 390 400
YGAGRSVPML RHFGGPDREP PRALEPDDRR RQKGLDYRLH GGAGDADFSY
410 420 430 440 450
RGPAGSIEQG PYDKMHASKR DALRQRFHSG NKSPEVLRAF DLPDTEAQEH
460 470 480 490 500
PEVVPSHKSP IMNTNLETGE LPGESTPTEY SQSAKDVSGQ VPSAGKSSPT
510 520 530
VDKAQLKTDS ECSPPGGCPP SKEAAVAAHG TEPVSSPCG
Length:539
Mass (Da):60,621
Last modified:June 1, 2001 - v1
Checksum:i252A3E095B56C1C4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AEM2A2AEM2_MOUSE
Chloride channel CLIC-like 1, isofo...
Clcc1 mCG_4070
544Annotation score:
Z4YMG1Z4YMG1_MOUSE
Chloride channel CLIC-like protein ...
Clcc1
84Annotation score:

Sequence cautioni

The sequence CAM17753 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK169803 mRNA Translation: BAE41377.1
AK171296 mRNA Translation: BAE42376.1
AL671917 Genomic DNA Translation: CAM17753.1 Sequence problems.
AL671917 Genomic DNA Translation: CAM17754.1
BC003247 mRNA Translation: AAH03247.1
CCDSiCCDS17766.1
RefSeqiNP_001171242.1, NM_001177771.1
NP_663518.1, NM_145543.2
XP_006501479.1, XM_006501416.3
XP_017175050.1, XM_017319561.1
UniGeneiMm.214545

Genome annotation databases

EnsembliENSMUST00000029483; ENSMUSP00000029483; ENSMUSG00000027884
ENSMUST00000106609; ENSMUSP00000102220; ENSMUSG00000027884
GeneIDi229725
KEGGimmu:229725
UCSCiuc008qzk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK169803 mRNA Translation: BAE41377.1
AK171296 mRNA Translation: BAE42376.1
AL671917 Genomic DNA Translation: CAM17753.1 Sequence problems.
AL671917 Genomic DNA Translation: CAM17754.1
BC003247 mRNA Translation: AAH03247.1
CCDSiCCDS17766.1
RefSeqiNP_001171242.1, NM_001177771.1
NP_663518.1, NM_145543.2
XP_006501479.1, XM_006501416.3
XP_017175050.1, XM_017319561.1
UniGeneiMm.214545

3D structure databases

ProteinModelPortaliQ99LI2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99LI2, 2 interactors
STRINGi10090.ENSMUSP00000102224

PTM databases

iPTMnetiQ99LI2
PhosphoSitePlusiQ99LI2
SwissPalmiQ99LI2

Proteomic databases

EPDiQ99LI2
MaxQBiQ99LI2
PaxDbiQ99LI2
PeptideAtlasiQ99LI2
PRIDEiQ99LI2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029483; ENSMUSP00000029483; ENSMUSG00000027884
ENSMUST00000106609; ENSMUSP00000102220; ENSMUSG00000027884
GeneIDi229725
KEGGimmu:229725
UCSCiuc008qzk.2 mouse

Organism-specific databases

CTDi23155
MGIiMGI:2385186 Clcc1

Phylogenomic databases

eggNOGiENOG410IJAP Eukaryota
ENOG41108E0 LUCA
GeneTreeiENSGT00390000016611
HOGENOMiHOG000231351
HOVERGENiHBG060364
InParanoidiQ99LI2
KOiK22188

Miscellaneous databases

ChiTaRSiClcc1 mouse
PROiPR:Q99LI2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027884 Expressed in 271 organ(s), highest expression level in primary oocyte
CleanExiMM_CLCC1
ExpressionAtlasiQ99LI2 baseline and differential
GenevisibleiQ99LI2 MM

Family and domain databases

InterProiView protein in InterPro
IPR009231 Chloride_chnl_CLIC-like
PANTHERiPTHR34093 PTHR34093, 1 hit
PfamiView protein in Pfam
PF05934 MCLC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLCC1_MOUSE
AccessioniPrimary (citable) accession number: Q99LI2
Secondary accession number(s): A2AEK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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