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Protein

Nucleolar GTP-binding protein 2

Gene

Gnl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi317 – 324GTPSequence analysis8
Nucleotide bindingi361 – 365GTPSequence analysis5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 2
Gene namesi
Name:Gnl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2385207 Gnl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158071 – 728Nucleolar GTP-binding protein 2Add BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei504PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99LH1
MaxQBiQ99LH1
PaxDbiQ99LH1
PRIDEiQ99LH1

PTM databases

iPTMnetiQ99LH1
PhosphoSitePlusiQ99LH1

Expressioni

Gene expression databases

BgeeiENSMUSG00000028869 Expressed in 291 organ(s), highest expression level in floor plate of midbrain
ExpressionAtlasiQ99LH1 baseline and differential
GenevisibleiQ99LH1 MM

Interactioni

Subunit structurei

Interacts with LYAR and RPL23A (By similarity). Interacts with the nuclear importin-beta receptor and, at a lower extent, with importin-alpha (By similarity).By similarity

Protein-protein interaction databases

BioGridi231010, 2 interactors
CORUMiQ99LH1
IntActiQ99LH1, 2 interactors
MINTiQ99LH1
STRINGi10090.ENSMUSP00000030684

Structurei

3D structure databases

ProteinModelPortaliQ99LH1
SMRiQ99LH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 368CP-type GPROSITE-ProRule annotationAdd BLAST162

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2423 Eukaryota
COG1161 LUCA
GeneTreeiENSGT00810000125524
HOGENOMiHOG000189714
HOVERGENiHBG052643
InParanoidiQ99LH1
KOiK14537
OMAiFAKSEEQ
OrthoDBiEOG091G055D
TreeFamiTF105668

Family and domain databases

Gene3Di1.10.1580.10, 1 hit
InterProiView protein in InterPro
IPR030378 G_CP_dom
IPR023179 GTP-bd_ortho_bundle_sf
IPR006073 GTP_binding_domain
IPR024929 NOG2
IPR012971 NOG2_N_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11089:SF9 PTHR11089:SF9, 1 hit
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF08153 NGP1NT, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51721 G_CP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99LH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKPKYKGRS TINRSAASTN PDRVQGAGGQ NMRDRGTIRR LNMYRQKERR
60 70 80 90 100
NSRGKVIKPL QYQSTVASGT VARVEPNIKW FGNTRVIKQA SLQKFQEEMD
110 120 130 140 150
KVMKDPYKVV MKQSKLPMSL LHDRIQPHNA KVHILDTESF ESTFGPKSQR
160 170 180 190 200
KRPNLFASDM QSLLENAEMS TESYDQGKDR DLVMEDTGVR NEAQEEIYKK
210 220 230 240 250
GQSKRIWGEL YKVIDSSDVV VQVLDARDPM GTRSPHIEAY LKKEKPWKHL
260 270 280 290 300
IFVLNKCDLV PTWATKRWVA VLSQDYPTLA FHASLTNPFG KGAFIQLLRQ
310 320 330 340 350
FGKLHTDKKQ ISVGFIGYPN VGKSSVINTL RSKKVCNVAP IAGETKVWQY
360 370 380 390 400
ITLMRRIFLI DCPGVVYPSE DSETDIVLKG VVQVEKIKAP QDHIGAVLER
410 420 430 440 450
AKPEYISKTY KIESWENAED FLEKLALRTG KLLKGGEPDM LTVSKMVLND
460 470 480 490 500
WQRGRIPFFV KPPNAELPTD SQLPPSSPLE VPTETTQNNP EEETTETEVE
510 520 530 540 550
RSDSITEKEP EGDCSQDRNS EMQQILARVR QNFGKINVGP QFSADDLVPV
560 570 580 590 600
EMSDLEDLES SGEEEEQEQE QPGEDAEEER SPDTQEEPVG NDTKAVLRAL
610 620 630 640 650
DEKIAKYQRF LNKAKAKKFS AVRISKDLSE KVFAKYKEEK KTSAEDSDAA
660 670 680 690 700
PTKKARKWDA QMEEEPSNKT QRMLTCKERR RAARQQQSKK VGVRYYETHN
710 720
VKNRNRNKKK TSDSEGQKHR RNKFRQKQ
Length:728
Mass (Da):83,345
Last modified:July 27, 2011 - v2
Checksum:iAB449483ABEFE956
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ASC2B1ASC2_MOUSE
Nucleolar GTP-binding protein 2
Gnl2
100Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176Q → K in BAC36850 (PubMed:16141072).Curated1
Sequence conflicti467L → I in AAH03262 (PubMed:15489334).Curated1
Sequence conflicti530R → S in BAC36850 (PubMed:16141072).Curated1
Sequence conflicti646D → V in AAH03262 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077532 mRNA Translation: BAC36850.1
AL626775 Genomic DNA No translation available.
BC003262 mRNA Translation: AAH03262.1
CCDSiCCDS18634.1
RefSeqiNP_663527.2, NM_145552.2
UniGeneiMm.90760

Genome annotation databases

EnsembliENSMUST00000030684; ENSMUSP00000030684; ENSMUSG00000028869
GeneIDi230737
KEGGimmu:230737
UCSCiuc008uro.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077532 mRNA Translation: BAC36850.1
AL626775 Genomic DNA No translation available.
BC003262 mRNA Translation: AAH03262.1
CCDSiCCDS18634.1
RefSeqiNP_663527.2, NM_145552.2
UniGeneiMm.90760

3D structure databases

ProteinModelPortaliQ99LH1
SMRiQ99LH1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231010, 2 interactors
CORUMiQ99LH1
IntActiQ99LH1, 2 interactors
MINTiQ99LH1
STRINGi10090.ENSMUSP00000030684

PTM databases

iPTMnetiQ99LH1
PhosphoSitePlusiQ99LH1

Proteomic databases

EPDiQ99LH1
MaxQBiQ99LH1
PaxDbiQ99LH1
PRIDEiQ99LH1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030684; ENSMUSP00000030684; ENSMUSG00000028869
GeneIDi230737
KEGGimmu:230737
UCSCiuc008uro.2 mouse

Organism-specific databases

CTDi29889
MGIiMGI:2385207 Gnl2

Phylogenomic databases

eggNOGiKOG2423 Eukaryota
COG1161 LUCA
GeneTreeiENSGT00810000125524
HOGENOMiHOG000189714
HOVERGENiHBG052643
InParanoidiQ99LH1
KOiK14537
OMAiFAKSEEQ
OrthoDBiEOG091G055D
TreeFamiTF105668

Miscellaneous databases

ChiTaRSiGnl2 mouse
PROiPR:Q99LH1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028869 Expressed in 291 organ(s), highest expression level in floor plate of midbrain
ExpressionAtlasiQ99LH1 baseline and differential
GenevisibleiQ99LH1 MM

Family and domain databases

Gene3Di1.10.1580.10, 1 hit
InterProiView protein in InterPro
IPR030378 G_CP_dom
IPR023179 GTP-bd_ortho_bundle_sf
IPR006073 GTP_binding_domain
IPR024929 NOG2
IPR012971 NOG2_N_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11089:SF9 PTHR11089:SF9, 1 hit
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF08153 NGP1NT, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51721 G_CP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOG2_MOUSE
AccessioniPrimary (citable) accession number: Q99LH1
Secondary accession number(s): B1ASC3, Q8BIF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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