Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transportin-2

Gene

Tnpo2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

GO - Molecular functioni

  • nuclear localization sequence binding Source: GO_Central
  • Ran GTPase binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transportin-2
Alternative name(s):
Karyopherin beta-2b
Gene namesi
Name:Tnpo2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2384849 Tnpo2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207681 – 887Transportin-2Add BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei852N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99LG2
MaxQBiQ99LG2
PaxDbiQ99LG2
PeptideAtlasiQ99LG2
PRIDEiQ99LG2

PTM databases

iPTMnetiQ99LG2
PhosphoSitePlusiQ99LG2
SwissPalmiQ99LG2

Expressioni

Gene expression databases

CleanExiMM_TNPO2
ExpressionAtlasiQ99LG2 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091051

Structurei

3D structure databases

ProteinModelPortaliQ99LG2
SMRiQ99LG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 36HEAT 1By similarityAdd BLAST28
Domaini31 – 99Importin N-terminalAdd BLAST69
Repeati41 – 79HEAT 2By similarityAdd BLAST39
Repeati88 – 121HEAT 3By similarityAdd BLAST34
Repeati127 – 164HEAT 4By similarityAdd BLAST38
Repeati171 – 201HEAT 5By similarityAdd BLAST31
Repeati214 – 241HEAT 6By similarityAdd BLAST28
Repeati253 – 280HEAT 7By similarityAdd BLAST28
Repeati296 – 386HEAT 8By similarityAdd BLAST91
Repeati394 – 422HEAT 9By similarityAdd BLAST29
Repeati434 – 461HEAT 10By similarityAdd BLAST28
Repeati475 – 508HEAT 11By similarityAdd BLAST34
Repeati516 – 549HEAT 12By similarityAdd BLAST34
Repeati557 – 595HEAT 13By similarityAdd BLAST39
Repeati603 – 654HEAT 14By similarityAdd BLAST52
Repeati665 – 696HEAT 15By similarityAdd BLAST32
Repeati704 – 737HEAT 16By similarityAdd BLAST34
Repeati745 – 780HEAT 17By similarityAdd BLAST36
Repeati788 – 821HEAT 18By similarityAdd BLAST34
Repeati830 – 861HEAT 19By similarityAdd BLAST32
Repeati864 – 884HEAT 20By similarityAdd BLAST21

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2023 Eukaryota
ENOG410XPK2 LUCA
GeneTreeiENSGT00550000074720
HOVERGENiHBG058963
InParanoidiQ99LG2
KOiK18727
OMAiINVFTPR
PhylomeDBiQ99LG2

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99LG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDWQPDEQGL QQVLQLLKDS QSPNTATQRI VQDKLKQLNQ FPDFNNYLIF
60 70 80 90 100
VLTRLKSEDE PTRSLSGLIL KNNVKAHYQS FPPPVADFIK QECLNNIGDA
110 120 130 140 150
SSLIRATIGI LITTIASKGE LQMWPELLPQ LCNLLNSEDY NTCEGAFGAL
160 170 180 190 200
QKICEDSSEL LDSDALNRPL NIMIPKFLQF FKHCSPKIRS HAIACVNQFI
210 220 230 240 250
MDRAQALMDN IDTFIEHLFA LAVDDDPEVR KNVCRALVML LEVRIDRLIP
260 270 280 290 300
HMHSIIQYML QRTQDHDENV ALEACEFWLT LAEQPICKEV LASHLVQLIP
310 320 330 340 350
ILVNGMKYSE IDIILLKGDV EEDEAVPDSE QDIKPRFHKS RTVTLTHEAE
360 370 380 390 400
RPDSSEDAED DDDDDALSDW NLRKCSAAAL DVLANVFREE LLPHLLPLLK
410 420 430 440 450
GLLFHPEWVV KESGILVLGA IAEGCMQGMV PYLPELIPHL IQCLSDKKAL
460 470 480 490 500
VRSIACWTLS RYAHWVVSQP PDMHLKPLMT ELLKRILDGN KRVQEAACSA
510 520 530 540 550
FATLEEEACT ELVPYLSYIL DTLVFAFGKY QHKNLLILYD AIGTLADSVG
560 570 580 590 600
HHLNQPEYIQ KLMPPLIQKW NELKDEDKDL FPLLECLSSV ATALQSGFLP
610 620 630 640 650
YCEPVYQRCV TLVQKTLAQA MMYTQHPEQY EAPDKDFMIV ALDLLSGLAE
660 670 680 690 700
GLGGHVEQLV ARSNIMTLLF QCMQDSMPEV RQSSFALLGD LTKACFIHVK
710 720 730 740 750
PCIAEFMPIL GTNLNPEFIS VCNNATWAIG EICMQMGAEM QPYVQMVLNN
760 770 780 790 800
LVEIINRPNT PKTLLENTAI TIGRLGYVCP QEVAPMLQQF IRPWCTSLRN
810 820 830 840 850
IRDNEEKDSA FRGICMMIGV NPGGVVQDFI FFCDAVASWV SPKDDLRDMF
860 870 880
YKILHGFKDQ VGEENWQQFS EQFPPLLKER LAAFYGV
Length:887
Mass (Da):100,456
Last modified:June 1, 2001 - v1
Checksum:i0A633DCE4DAC4E93
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PV58E9PV58_MOUSE
Transportin-2
Tnpo2
897Annotation score:
A0A1B0GT37A0A1B0GT37_MOUSE
Transportin-2
Tnpo2
137Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti361D → G in BAC26611 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003275 mRNA Translation: AAH03275.1
AK029774 mRNA Translation: BAC26611.1
RefSeqiNP_001116315.1, NM_001122843.1
NP_663365.3, NM_145390.4
XP_011246644.1, XM_011248342.2
XP_011246647.1, XM_011248345.2
XP_017168136.1, XM_017312647.1
XP_017168137.1, XM_017312648.1
UniGeneiMm.220357

Genome annotation databases

EnsembliENSMUST00000211601; ENSMUSP00000147583; ENSMUSG00000031691
GeneIDi212999
KEGGimmu:212999
UCSCiuc009mpa.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003275 mRNA Translation: AAH03275.1
AK029774 mRNA Translation: BAC26611.1
RefSeqiNP_001116315.1, NM_001122843.1
NP_663365.3, NM_145390.4
XP_011246644.1, XM_011248342.2
XP_011246647.1, XM_011248345.2
XP_017168136.1, XM_017312647.1
XP_017168137.1, XM_017312648.1
UniGeneiMm.220357

3D structure databases

ProteinModelPortaliQ99LG2
SMRiQ99LG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091051

PTM databases

iPTMnetiQ99LG2
PhosphoSitePlusiQ99LG2
SwissPalmiQ99LG2

Proteomic databases

EPDiQ99LG2
MaxQBiQ99LG2
PaxDbiQ99LG2
PeptideAtlasiQ99LG2
PRIDEiQ99LG2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000211601; ENSMUSP00000147583; ENSMUSG00000031691
GeneIDi212999
KEGGimmu:212999
UCSCiuc009mpa.2 mouse

Organism-specific databases

CTDi30000
MGIiMGI:2384849 Tnpo2

Phylogenomic databases

eggNOGiKOG2023 Eukaryota
ENOG410XPK2 LUCA
GeneTreeiENSGT00550000074720
HOVERGENiHBG058963
InParanoidiQ99LG2
KOiK18727
OMAiINVFTPR
PhylomeDBiQ99LG2

Miscellaneous databases

PROiPR:Q99LG2
SOURCEiSearch...

Gene expression databases

CleanExiMM_TNPO2
ExpressionAtlasiQ99LG2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNPO2_MOUSE
AccessioniPrimary (citable) accession number: Q99LG2
Secondary accession number(s): Q8C0U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again