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Protein
Submitted name:

DDB1 and CUL4-associated factor 4

Gene

Dcaf4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Submitted name:
DDB1 and CUL4-associated factor 4Imported
Submitted name:
WD repeat domain 21Imported
Gene namesi
Name:Dcaf4Imported
Synonyms:Wdr21Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1921078 Dcaf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000021222 Expressed in 265 organ(s), highest expression level in decidua

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021645

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini367 – 452WD_REPEATS_REGIONInterPro annotationAdd BLAST86
Repeati370 – 408WDPROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2695 Eukaryota
ENOG410XQIU LUCA
GeneTreeiENSGT00390000009546
HOGENOMiHOG000065756
HOVERGENiHBG054724
OMAiYLMASDM
OrthoDBiEOG091G06QG
TreeFamiTF332050

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 2 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q99LF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRNIWKSRR RRGRSRHQSP ALGQCDSSER YATGASQSSQ DSGHHDAESP
60 70 80 90 100
STSSSRTGES SVPELPGFYF DPEKNRYFRL LPGHNNCNPL TKEGIQQKEM
110 120 130 140 150
ESRRLQLLQQ EDMQKKKITR VGFNASSILR KNQLGFLNFS SYCRLSHELR
160 170 180 190 200
VSCMERKKVE IQSSDPSALA SDRFNFIMAD TTSDRLFTVN DVKIGGSKYG
210 220 230 240 250
IINLQGLKAP TFEVQMHENL YFTNRKVNSV CWASLNHLDS HILLCLMGLA
260 270 280 290 300
ETPGCATLLP ASLFVSNHQA GTDQPGMLCS FRIPGAWSCA WSLNVQANNC
310 320 330 340 350
FSTGLSRRVL LTNVVTGHRQ SYRINSDVLA QQFAVKTPLL FNGCRSGEIF
360 370 380 390 400
AIDLRSPSQA KGWKATQIFH DSAVTSVQVF KEEQHLMASD MSGKIKLWDL
410 420 430 440 450
RATKCVRQYE GHVNEYAYLP LHMHEEEGIL VAVGQDCYTR IWSLHDARLL
460 470 480 490 500
RTIPSPCPTS KANIPSVAFS PRLGGSRGAP GLLMAVQQDL YCFAYSSSCP
510
DSQEEGRWEL PSVSNEDIL
Length:519
Mass (Da):58,117
Last modified:June 1, 2001 - v1
Checksum:i173593F00B6F2D99
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VNZ0A0A1Y7VNZ0_MOUSE
DDB1 and CUL4-associated factor 4
Dcaf4
532Annotation score:
A0A1Y7VIR8A0A1Y7VIR8_MOUSE
DDB1 and CUL4-associated factor 4
Dcaf4
84Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139382 Genomic DNA No translation available.
BC003284 mRNA Translation: AAH03284.1
RefSeqiNP_084522.1, NM_030246.2
UniGeneiMm.38238

Genome annotation databases

EnsembliENSMUST00000021645; ENSMUSP00000021645; ENSMUSG00000021222
GeneIDi73828
UCSCiuc007odf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ99LF7_MOUSE
AccessioniPrimary (citable) accession number: Q99LF7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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