UniProtKB - Q99LD9 (EI2BB_MOUSE)
Protein
Translation initiation factor eIF-2B subunit beta
Gene
Eif2b2
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.By similarity
GO - Molecular functioni
- ATP binding Source: UniProtKB
- GTP binding Source: UniProtKB
- guanyl-nucleotide exchange factor activity Source: Ensembl
- translation initiation factor activity Source: GO_Central
GO - Biological processi
- central nervous system development Source: UniProtKB
- myelination Source: UniProtKB
- oligodendrocyte development Source: UniProtKB
- ovarian follicle development Source: UniProtKB
- positive regulation of axon extension Source: MGI
- regulation of translational initiation Source: GO_Central
- response to glucose Source: MGI
- response to heat Source: MGI
- response to peptide hormone Source: MGI
- T cell receptor signaling pathway Source: UniProtKB
- translational initiation Source: UniProtKB
Keywordsi
Molecular function | Initiation factor |
Biological process | Protein biosynthesis |
Enzyme and pathway databases
Reactomei | R-MMU-72731, Recycling of eIF2:GDP |
Names & Taxonomyi
Protein namesi | Recommended name: Translation initiation factor eIF-2B subunit betaAlternative name(s): eIF-2B GDP-GTP exchange factor subunit beta |
Gene namesi | Name:Eif2b2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2145118, Eif2b2 |
Subcellular locationi
Other locations
- axon Source: MGI
- cytoplasm Source: UniProtKB
- eukaryotic translation initiation factor 2B complex Source: UniProtKB
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156062 | 1 – 351 | Translation initiation factor eIF-2B subunit betaAdd BLAST | 351 |
Proteomic databases
EPDi | Q99LD9 |
MaxQBi | Q99LD9 |
PaxDbi | Q99LD9 |
PeptideAtlasi | Q99LD9 |
PRIDEi | Q99LD9 |
PTM databases
iPTMneti | Q99LD9 |
PhosphoSitePlusi | Q99LD9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000004788, Expressed in substantia nigra and 314 other tissues |
ExpressionAtlasi | Q99LD9, baseline and differential |
Genevisiblei | Q99LD9, MM |
Interactioni
Subunit structurei
Complex of five different subunits; alpha, beta, gamma, delta and epsilon.
By similarityGO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 229952, 1 interactor |
IntActi | Q99LD9, 2 interactors |
MINTi | Q99LD9 |
STRINGi | 10090.ENSMUSP00000004910 |
Miscellaneous databases
RNActi | Q99LD9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the eIF-2B alpha/beta/delta subunits family.Curated
Phylogenomic databases
eggNOGi | KOG1465, Eukaryota |
GeneTreei | ENSGT00550000074908 |
HOGENOMi | CLU_016218_4_3_1 |
InParanoidi | Q99LD9 |
OMAi | DHIHSDE |
OrthoDBi | 918011at2759 |
PhylomeDBi | Q99LD9 |
TreeFami | TF101506 |
Family and domain databases
Gene3Di | 3.40.50.10470, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR042529, IF_2B-like_C IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q99LD9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGAAAKGSE LSERIEGFVE TLKRGGGQRS SEDMARETLG LLRRLITDHH
60 70 80 90 100
WNNAGDLMDL IRREGRRMTA AQPSETTVGN MVRRVLKIIR EEYGRLHGRS
110 120 130 140 150
DESDQQESLH KLLTSGGLSE DFSFHFAPLK ANIIEAINEL LVELEGTMEN
160 170 180 190 200
IAAQALEHIH SNEVIMTIGY SRTVEAFLKE AARKRKFHVI VAECAPFCQG
210 220 230 240 250
HEMAVNLSKE GIETTVMTDA AIFAVMSRVN KVIIGTKTIL ANGSLRAVAG
260 270 280 290 300
THTLALAAKH HSTPLIVCAP MFKLSPQFPS EEDSFHKFVA PEEVLPFTEG
310 320 330 340 350
DILEKVSVHC PVFDYVPPDL ITLFISNIGG NAPSYIYRLM SELYHPDDHV
L
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z487 | D3Z487_MOUSE | Translation initiation factor eIF-2... | Eif2b2 | 302 | Annotation score: | ||
D3Z7J6 | D3Z7J6_MOUSE | Translation initiation factor eIF-2... | Eif2b2 | 228 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK049731 mRNA Translation: BAC33897.1 BC003326 mRNA Translation: AAH03326.1 |
CCDSi | CCDS26053.1 |
RefSeqi | NP_663420.1, NM_145445.4 |
Genome annotation databases
Ensembli | ENSMUST00000004910; ENSMUSP00000004910; ENSMUSG00000004788 |
GeneIDi | 217715 |
KEGGi | mmu:217715 |
UCSCi | uc007ogr.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK049731 mRNA Translation: BAC33897.1 BC003326 mRNA Translation: AAH03326.1 |
CCDSi | CCDS26053.1 |
RefSeqi | NP_663420.1, NM_145445.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 229952, 1 interactor |
IntActi | Q99LD9, 2 interactors |
MINTi | Q99LD9 |
STRINGi | 10090.ENSMUSP00000004910 |
PTM databases
iPTMneti | Q99LD9 |
PhosphoSitePlusi | Q99LD9 |
Proteomic databases
EPDi | Q99LD9 |
MaxQBi | Q99LD9 |
PaxDbi | Q99LD9 |
PeptideAtlasi | Q99LD9 |
PRIDEi | Q99LD9 |
Protocols and materials databases
Antibodypediai | 57, 175 antibodies |
DNASUi | 217715 |
Genome annotation databases
Ensembli | ENSMUST00000004910; ENSMUSP00000004910; ENSMUSG00000004788 |
GeneIDi | 217715 |
KEGGi | mmu:217715 |
UCSCi | uc007ogr.1, mouse |
Organism-specific databases
CTDi | 8892 |
MGIi | MGI:2145118, Eif2b2 |
Phylogenomic databases
eggNOGi | KOG1465, Eukaryota |
GeneTreei | ENSGT00550000074908 |
HOGENOMi | CLU_016218_4_3_1 |
InParanoidi | Q99LD9 |
OMAi | DHIHSDE |
OrthoDBi | 918011at2759 |
PhylomeDBi | Q99LD9 |
TreeFami | TF101506 |
Enzyme and pathway databases
Reactomei | R-MMU-72731, Recycling of eIF2:GDP |
Miscellaneous databases
BioGRID-ORCSi | 217715, 10 hits in 18 CRISPR screens |
ChiTaRSi | Eif2b2, mouse |
PROi | PR:Q99LD9 |
RNActi | Q99LD9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004788, Expressed in substantia nigra and 314 other tissues |
ExpressionAtlasi | Q99LD9, baseline and differential |
Genevisiblei | Q99LD9, MM |
Family and domain databases
Gene3Di | 3.40.50.10470, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR042529, IF_2B-like_C IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EI2BB_MOUSE | |
Accessioni | Q99LD9Primary (citable) accession number: Q99LD9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families