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Protein

Translation initiation factor eIF-2B subunit beta

Gene

Eif2b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-72731 Recycling of eIF2:GDP

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit beta
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit beta
Gene namesi
Name:Eif2b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2145118 Eif2b2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560621 – 351Translation initiation factor eIF-2B subunit betaAdd BLAST351

Proteomic databases

EPDiQ99LD9
MaxQBiQ99LD9
PaxDbiQ99LD9
PeptideAtlasiQ99LD9
PRIDEiQ99LD9

PTM databases

iPTMnetiQ99LD9
PhosphoSitePlusiQ99LD9

Expressioni

Gene expression databases

BgeeiENSMUSG00000004788 Expressed in 297 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ99LD9 baseline and differential
GenevisibleiQ99LD9 MM

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ99LD9, 1 interactor
MINTiQ99LD9
STRINGi10090.ENSMUSP00000004910

Structurei

3D structure databases

ProteinModelPortaliQ99LD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1465 Eukaryota
COG1184 LUCA
GeneTreeiENSGT00550000074908
HOGENOMiHOG000208487
HOVERGENiHBG051458
InParanoidiQ99LD9
KOiK03754
OMAiDHRWSNA
OrthoDBiEOG091G09RO
PhylomeDBiQ99LD9
TreeFamiTF101506

Family and domain databases

InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99LD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGAAAKGSE LSERIEGFVE TLKRGGGQRS SEDMARETLG LLRRLITDHH
60 70 80 90 100
WNNAGDLMDL IRREGRRMTA AQPSETTVGN MVRRVLKIIR EEYGRLHGRS
110 120 130 140 150
DESDQQESLH KLLTSGGLSE DFSFHFAPLK ANIIEAINEL LVELEGTMEN
160 170 180 190 200
IAAQALEHIH SNEVIMTIGY SRTVEAFLKE AARKRKFHVI VAECAPFCQG
210 220 230 240 250
HEMAVNLSKE GIETTVMTDA AIFAVMSRVN KVIIGTKTIL ANGSLRAVAG
260 270 280 290 300
THTLALAAKH HSTPLIVCAP MFKLSPQFPS EEDSFHKFVA PEEVLPFTEG
310 320 330 340 350
DILEKVSVHC PVFDYVPPDL ITLFISNIGG NAPSYIYRLM SELYHPDDHV

L
Length:351
Mass (Da):38,898
Last modified:June 1, 2001 - v1
Checksum:i56FF1B8A96845853
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7J6D3Z7J6_MOUSE
Translation initiation factor eIF-2...
Eif2b2
228Annotation score:
D3Z487D3Z487_MOUSE
Translation initiation factor eIF-2...
Eif2b2
302Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049731 mRNA Translation: BAC33897.1
BC003326 mRNA Translation: AAH03326.1
CCDSiCCDS26053.1
RefSeqiNP_663420.1, NM_145445.4
UniGeneiMm.29041

Genome annotation databases

EnsembliENSMUST00000004910; ENSMUSP00000004910; ENSMUSG00000004788
GeneIDi217715
KEGGimmu:217715
UCSCiuc007ogr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049731 mRNA Translation: BAC33897.1
BC003326 mRNA Translation: AAH03326.1
CCDSiCCDS26053.1
RefSeqiNP_663420.1, NM_145445.4
UniGeneiMm.29041

3D structure databases

ProteinModelPortaliQ99LD9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99LD9, 1 interactor
MINTiQ99LD9
STRINGi10090.ENSMUSP00000004910

PTM databases

iPTMnetiQ99LD9
PhosphoSitePlusiQ99LD9

Proteomic databases

EPDiQ99LD9
MaxQBiQ99LD9
PaxDbiQ99LD9
PeptideAtlasiQ99LD9
PRIDEiQ99LD9

Protocols and materials databases

DNASUi217715
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004910; ENSMUSP00000004910; ENSMUSG00000004788
GeneIDi217715
KEGGimmu:217715
UCSCiuc007ogr.1 mouse

Organism-specific databases

CTDi8892
MGIiMGI:2145118 Eif2b2

Phylogenomic databases

eggNOGiKOG1465 Eukaryota
COG1184 LUCA
GeneTreeiENSGT00550000074908
HOGENOMiHOG000208487
HOVERGENiHBG051458
InParanoidiQ99LD9
KOiK03754
OMAiDHRWSNA
OrthoDBiEOG091G09RO
PhylomeDBiQ99LD9
TreeFamiTF101506

Enzyme and pathway databases

ReactomeiR-MMU-72731 Recycling of eIF2:GDP

Miscellaneous databases

ChiTaRSiEif2b2 mouse
PROiPR:Q99LD9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004788 Expressed in 297 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ99LD9 baseline and differential
GenevisibleiQ99LD9 MM

Family and domain databases

InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BB_MOUSE
AccessioniPrimary (citable) accession number: Q99LD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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