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Protein

COP9 signalosome complex subunit 1

Gene

Gps1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 1
Short name:
SGN1
Short name:
Signalosome subunit 1
Alternative name(s):
G protein pathway suppressor 1
Short name:
GPS-1
JAB1-containing signalosome subunit 1
Gene namesi
Name:Gps1
Synonyms:Cops1, Csn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2384801 Gps1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001209601 – 471COP9 signalosome complex subunit 1Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei448PhosphoserineBy similarity1
Modified residuei454PhosphoserineCombined sources1
Modified residuei459PhosphothreonineCombined sources1
Modified residuei463PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99LD4
PaxDbiQ99LD4
PeptideAtlasiQ99LD4
PRIDEiQ99LD4

PTM databases

iPTMnetiQ99LD4
PhosphoSitePlusiQ99LD4

Expressioni

Tissue specificityi

Expressed in the base region of the oxyntic and pyloric mucosae.1 Publication

Gene expression databases

CleanExiMM_GPS1

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and COPS5 (By similarity). Interacts directly with inositol kinase ITPK1 (By similarity). Interacts with CAPN8 (PubMed:16476741).By similarity2 Publications

Protein-protein interaction databases

CORUMiQ99LD4
IntActiQ99LD4, 7 interactors
MINTiQ99LD4
STRINGi10090.ENSMUSP00000133855

Structurei

3D structure databases

ProteinModelPortaliQ99LD4
SMRiQ99LD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini249 – 411PCIPROSITE-ProRule annotationAdd BLAST163

Domaini

The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex (By similarity). Mediates the interaction with CAPN8.By similarity1 Publication
The N-terminal part (1-196), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression.By similarity

Sequence similaritiesi

Belongs to the CSN1 family.Curated

Phylogenomic databases

eggNOGiKOG0686 Eukaryota
ENOG410XRXI LUCA
HOVERGENiHBG030722
InParanoidiQ99LD4

Family and domain databases

InterProiView protein in InterPro
IPR033008 CSN1
IPR000717 PCI_dom
IPR019585 Rpn7/CSN1
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR14145:SF2 PTHR14145:SF2, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
PF10602 RPN7, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99LD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQIDVDPQED PQNAPDVNYV VENPTLDLEQ YAASYSGLMR IERLQFIADR
60 70 80 90 100
CPPLRVEALK MALSFVQRTF NVDMYEEIHR KLSEATRELQ NAPDAIPESG
110 120 130 140 150
VEPPPLDTAW VEATRKKALL KLEKLDTDLK NYKGNSIKES IRRGHDDLGD
160 170 180 190 200
HYLDCGDLSN ALKCYSRARD YCTSAKHVIN MCLNVIKVSV YLQNWSHVLS
210 220 230 240 250
YVSKAESTPE IAEQRGERDS QTQAILTKLK CAAGLAELAA RKYKQAAKCF
260 270 280 290 300
LLASFDHCDF PELLSPSNVA VYGGLCALAT FDRQELQRNV ISSSSFKLFL
310 320 330 340 350
ELEPQVRDII FKFYESKYAS CLKMLDEMKD NLLLDMYLAP HVRTLYTQIR
360 370 380 390 400
NRALIQYFSP YVSADMHKMA AAFNTTVAAL EDELTQLILE GLINARIDSH
410 420 430 440 450
SKILYARDVD QRSTTFEKSL LMGKEFQRRA KAMILRAAVL RNQIHVKSPP
460 470
REGSQGELTP ANSQSRMSTN M
Length:471
Mass (Da):53,442
Last modified:June 1, 2001 - v1
Checksum:i578A269A8FF63D61
GO
Isoform 2 (identifier: Q99LD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     448-471: SPPREGSQGELTPANSQSRMSTNM → VKSLGCEGMGGTHTASTEPSLSTAVSS

Note: No experimental confirmation available.
Show »
Length:474
Mass (Da):53,474
Checksum:iA1DAEF72936AC915
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3MIA8Q3MIA8_MOUSE
COP9 signalosome complex subunit 1
Gps1
487Annotation score:
B1ATU4B1ATU4_MOUSE
COP9 signalosome complex subunit 1
Gps1 mCG_2137
490Annotation score:
G3UXW9G3UXW9_MOUSE
COP9 signalosome complex subunit 1
Gps1 mCG_2137
526Annotation score:
A0A140LJB7A0A140LJB7_MOUSE
COP9 signalosome complex subunit 1
Gps1
486Annotation score:
D6RCV3D6RCV3_MOUSE
COP9 signalosome complex subunit 1
Gps1
45Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011883448 – 471SPPRE…MSTNM → VKSLGCEGMGGTHTASTEPS LSTAVSS in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088490 mRNA Translation: BAC40386.1
AL663090 Genomic DNA No translation available.
BC003350 mRNA Translation: AAH03350.1
UniGeneiMm.30195

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088490 mRNA Translation: BAC40386.1
AL663090 Genomic DNA No translation available.
BC003350 mRNA Translation: AAH03350.1
UniGeneiMm.30195

3D structure databases

ProteinModelPortaliQ99LD4
SMRiQ99LD4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ99LD4
IntActiQ99LD4, 7 interactors
MINTiQ99LD4
STRINGi10090.ENSMUSP00000133855

PTM databases

iPTMnetiQ99LD4
PhosphoSitePlusiQ99LD4

Proteomic databases

EPDiQ99LD4
PaxDbiQ99LD4
PeptideAtlasiQ99LD4
PRIDEiQ99LD4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2384801 Gps1

Phylogenomic databases

eggNOGiKOG0686 Eukaryota
ENOG410XRXI LUCA
HOVERGENiHBG030722
InParanoidiQ99LD4

Miscellaneous databases

PROiPR:Q99LD4
SOURCEiSearch...

Gene expression databases

CleanExiMM_GPS1

Family and domain databases

InterProiView protein in InterPro
IPR033008 CSN1
IPR000717 PCI_dom
IPR019585 Rpn7/CSN1
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR14145:SF2 PTHR14145:SF2, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
PF10602 RPN7, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSN1_MOUSE
AccessioniPrimary (citable) accession number: Q99LD4
Secondary accession number(s): B0QZT1, Q8C2J7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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