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Protein

Translation initiation factor eIF-2B subunit alpha

Gene

Eif2b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-72731 Recycling of eIF2:GDP

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit alpha
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit alpha
Gene namesi
Name:Eif2b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2384802 Eif2b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560561 – 305Translation initiation factor eIF-2B subunit alphaAdd BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99LC8
MaxQBiQ99LC8
PaxDbiQ99LC8
PRIDEiQ99LC8

PTM databases

iPTMnetiQ99LC8
PhosphoSitePlusiQ99LC8

Expressioni

Gene expression databases

BgeeiENSMUSG00000029388 Expressed in 329 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ99LC8 baseline and differential
GenevisibleiQ99LC8 MM

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229070, 2 interactors
IntActiQ99LC8, 1 interactor
STRINGi10090.ENSMUSP00000031334

Structurei

3D structure databases

ProteinModelPortaliQ99LC8
SMRiQ99LC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1466 Eukaryota
COG1184 LUCA
GeneTreeiENSGT00550000074853
HOGENOMiHOG000175731
HOVERGENiHBG051457
InParanoidiQ99LC8
KOiK03239
OMAiQYLVGMF
OrthoDBiEOG091G0CQR
PhylomeDBiQ99LC8
TreeFamiTF101505

Family and domain databases

InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q99LC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDGELIEYF KSQMKGDPKM ASAVAAIQTL LEFLKRDKGE TLQGLRANLT
60 70 80 90 100
YAIKTLCGVD SSVAVSSGGE LFLRFISLTS LEYSDYSKCK KIMIERGELF
110 120 130 140 150
LRRISLSRNK IANLCHTFIK DGARILTHAY SRVVLRVLEE AVAAKKRFSV
160 170 180 190 200
YITESQPDLS GKKMAKALSH LNVPVTVVLD AAVGYIMEKA DLVIVGAEGV
210 220 230 240 250
VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP LNQEDVPDKF
260 270 280 290 300
KYKADTLKSV QTGQDLKEEH PWVDYTSPSL ITLLFTDLGV LTPSAVSDEL

IKLYL
Length:305
Mass (Da):33,816
Last modified:June 1, 2001 - v1
Checksum:i9D9ED81F0D9B8411
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZ05D3YZ05_MOUSE
Translation initiation factor eIF-2...
Eif2b1
133Annotation score:
D3Z151D3Z151_MOUSE
Translation initiation factor eIF-2...
Eif2b1
185Annotation score:
A0A0G2JEF1A0A0G2JEF1_MOUSE
Translation initiation factor eIF-2...
Eif2b1
43Annotation score:
D6RI38D6RI38_MOUSE
Translation initiation factor eIF-2...
Eif2b1
44Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003426 mRNA Translation: AAH03426.1
CCDSiCCDS39282.1
RefSeqiNP_663346.1, NM_145371.4
UniGeneiMm.28839

Genome annotation databases

EnsembliENSMUST00000031334; ENSMUSP00000031334; ENSMUSG00000029388
GeneIDi209354
KEGGimmu:209354
UCSCiuc008zqd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003426 mRNA Translation: AAH03426.1
CCDSiCCDS39282.1
RefSeqiNP_663346.1, NM_145371.4
UniGeneiMm.28839

3D structure databases

ProteinModelPortaliQ99LC8
SMRiQ99LC8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229070, 2 interactors
IntActiQ99LC8, 1 interactor
STRINGi10090.ENSMUSP00000031334

PTM databases

iPTMnetiQ99LC8
PhosphoSitePlusiQ99LC8

Proteomic databases

EPDiQ99LC8
MaxQBiQ99LC8
PaxDbiQ99LC8
PRIDEiQ99LC8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031334; ENSMUSP00000031334; ENSMUSG00000029388
GeneIDi209354
KEGGimmu:209354
UCSCiuc008zqd.1 mouse

Organism-specific databases

CTDi1967
MGIiMGI:2384802 Eif2b1

Phylogenomic databases

eggNOGiKOG1466 Eukaryota
COG1184 LUCA
GeneTreeiENSGT00550000074853
HOGENOMiHOG000175731
HOVERGENiHBG051457
InParanoidiQ99LC8
KOiK03239
OMAiQYLVGMF
OrthoDBiEOG091G0CQR
PhylomeDBiQ99LC8
TreeFamiTF101505

Enzyme and pathway databases

ReactomeiR-MMU-72731 Recycling of eIF2:GDP

Miscellaneous databases

ChiTaRSiEif2b1 mouse
PROiPR:Q99LC8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029388 Expressed in 329 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ99LC8 baseline and differential
GenevisibleiQ99LC8 MM

Family and domain databases

InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BA_MOUSE
AccessioniPrimary (citable) accession number: Q99LC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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