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Protein

Deoxynucleotidyltransferase terminal-interacting protein 1

Gene

Dnttip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi158 – 172A.T hookCuratedAdd BLAST15
DNA bindingi215 – 236H-T-H motifCuratedAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxynucleotidyltransferase terminal-interacting protein 1
Alternative name(s):
Terminal deoxynucleotidyltransferase-interacting factor 1
Short name:
TdIF1
Short name:
TdT-interacting factor 1
Gene namesi
Name:Dnttip1
Synonyms:Tdif1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923483 Dnttip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724741 – 328Deoxynucleotidyltransferase terminal-interacting protein 1Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99LB0
MaxQBiQ99LB0
PaxDbiQ99LB0
PRIDEiQ99LB0

PTM databases

iPTMnetiQ99LB0
PhosphoSitePlusiQ99LB0

Expressioni

Gene expression databases

BgeeiENSMUSG00000017299 Expressed in 275 organ(s), highest expression level in striatum
ExpressionAtlasiQ99LB0 baseline and differential
GenevisibleiQ99LB0 MM

Interactioni

Subunit structurei

Monomer and homodimer (By similarity). A minor proportion may form homotrimers (By similarity). Interacts with ZNF541 (PubMed:18849567). Interacts with the terminal deoxynucleotidyltransferase DNTT (By similarity). Interacts with TRERF1 (By similarity). Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and ELMSAN1; this complex assembles into a tetramer that contains four copies of each protein chain (By similarity). Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218041, 1 interactor
IntActiQ99LB0, 2 interactors
MINTiQ99LB0
STRINGi10090.ENSMUSP00000017443

Structurei

3D structure databases

ProteinModelPortaliQ99LB0
SMRiQ99LB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 147Important for dimerizationBy similarityAdd BLAST92
Regioni196 – 315Important for DNA and nucleosome bindingBy similarityAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi163 – 169Nuclear localization signalSequence analysis7

Domaini

The N-terminal domain mediates dimerization.By similarity
The C-terminal domain mediates interaction with DNA and nucleosomes. It contains a HTH motif that mediates recognition of the consensus sequence.By similarity

Phylogenomic databases

eggNOGiKOG4801 Eukaryota
ENOG410XPIX LUCA
GeneTreeiENSGT00510000047836
HOGENOMiHOG000059597
HOVERGENiHBG057022
InParanoidiQ99LB0
KOiK08707
OMAiWMVEKMR
OrthoDBiEOG091G0E9R
PhylomeDBiQ99LB0
TreeFamiTF329275

Family and domain databases

InterProiView protein in InterPro
IPR026064 TdIF1
PANTHERiPTHR23399 PTHR23399, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q99LB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGATGDTEQP RGPGGAERGG LELGDAGAAG QPVLTNPWNI MIKHRQVQRR
60 70 80 90 100
GRRSQMTTSF TDPAISMDLL RAVLQPSINE EIQGVFNKYM KFFQKAALNV
110 120 130 140 150
RDNVGEEVDA EQLIQEACRS CLEQAKLLFS DGEKVIPRLA HELPGIKRGR
160 170 180 190 200
QAEEESHRGS PIPKKRKGRP PGHVLSNDRA AAGMVWKQKS CEPIRREGPK
210 220 230 240 250
WDPARLNEST TFVLGSRANK ALGMGGTRGR IYIKHPHLFK YAADPQDKHW
260 270 280 290 300
LAEQHHMRAT GGKMAYLLIE EDIRDLAASD DYRGCLDLKL EELKSFVLPS
310 320
WMVEKMRKYM ETLRTENEHR AAEAPPQT
Length:328
Mass (Da):36,852
Last modified:June 1, 2001 - v1
Checksum:i221D334D832F9AB1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A4Y7A2A4Y7_MOUSE
Deoxynucleotidyltransferase termina...
Dnttip1
111Annotation score:
F7B2G8F7B2G8_MOUSE
Deoxynucleotidyltransferase termina...
Dnttip1
211Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045974 mRNA Translation: BAB82521.1
BC003486 mRNA Translation: AAH03486.1
CCDSiCCDS17054.1
RefSeqiNP_598524.1, NM_133763.1
UniGeneiMm.440009

Genome annotation databases

EnsembliENSMUST00000017443; ENSMUSP00000017443; ENSMUSG00000017299
GeneIDi76233
KEGGimmu:76233
UCSCiuc008nvx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTDIF1_MOUSE
AccessioniPrimary (citable) accession number: Q99LB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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