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Protein

Microspherule protein 1

Gene

Mcrs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homopolymer poly(G) and poly(U).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3214847 HATs acetylate histones
R-MMU-5689603 UCH proteinases
R-MMU-5696394 DNA Damage Recognition in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
Microspherule protein 1
Alternative name(s):
58 kDa microspherule protein
Gene namesi
Name:Mcrs1
Synonyms:Msp58
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1858420 Mcrs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963061 – 462Microspherule protein 1Add BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei102PhosphoserineCombined sources1
Modified residuei103PhosphothreonineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei123N6-acetyllysineCombined sources1
Modified residuei130N6-acetyllysineCombined sources1
Modified residuei282PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99L90
MaxQBiQ99L90
PaxDbiQ99L90
PRIDEiQ99L90

PTM databases

iPTMnetiQ99L90
PhosphoSitePlusiQ99L90

Expressioni

Gene expression databases

BgeeiENSMUSG00000037570 Expressed in 50 organ(s), highest expression level in testis
CleanExiMM_MCRS1
ExpressionAtlasiQ99L90 baseline and differential
GenevisibleiQ99L90 MM

Interactioni

Subunit structurei

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with NOP2. Interacts with PINX1. Interacts with TERT. Interacts with CCDC85B. Interacts with DAXX. Interacts (via N-terminus) with FMR1 (via phosphorylated form). Interacts with FXR1 AND FXR2.By similarity

Protein-protein interaction databases

BioGridi206187, 1 interactor
ComplexPortaliCPX-875 NSL histone acetyltransferase complex
CPX-878 INO80 chromatin remodeling complex
STRINGi10090.ENSMUSP00000043901

Structurei

3D structure databases

ProteinModelPortaliQ99L90
SMRiQ99L90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini363 – 419FHAPROSITE-ProRule annotationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili301 – 335Sequence analysisAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi113 – 123Nuclear localization signalSequence analysisAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 102Ser-richAdd BLAST92

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2293 Eukaryota
ENOG410XS0S LUCA
GeneTreeiENSGT00390000005536
HOGENOMiHOG000007227
HOVERGENiHBG052434
InParanoidiQ99L90
KOiK11674
OMAiFLVNYEL
OrthoDBiEOG091G07QN
PhylomeDBiQ99L90
TreeFamiTF318119

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR037912 MCRS1
IPR025999 MCRS_N
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR13233 PTHR13233, 1 hit
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF13325 MCRS_N, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q99L90-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKDSQGLLD SSLMASGTAS RSEDEESLAG QKRASSQALG TIPKRRSSSR
60 70 80 90 100
FIKRKKFDDE LVESSLAKSS TRVKGAGGVE SGRCSGSEPS SSEKKKVSKA
110 120 130 140 150
PSTPVPPSPA PTPGLTKRVK KSKQPLQVTK DLGRWKPADD LLLINAVLQT
160 170 180 190 200
NDLTSVHLGV KFSCRFTLRE VQERWYALLY DPVISKLACQ AMRQLHPEAI
210 220 230 240 250
AAIQSKALFS KAEEQLLSKV GSSSQPTLET FQDLLHTHPD AFYLARTAKA
260 270 280 290 300
LQAHWQLMKQ YYLLEDQTVQ PLPKGDQVLN FSDAEDLIDD SKLKDMRDEV
310 320 330 340 350
LEHELTVADR RQKREIRQLE QELHKWQVLV DSITGMGSPD FDNQTLAVLR
360 370 380 390 400
GRMVRYLMRS REITLGRATK DNQIDVDLSL EGPAWKISRK QGVIKLKNNG
410 420 430 440 450
DFFIANEGRR PIYIDGRPVL CGSKWRLSNN SVVEIASLRF VFLINQDLIA
460
LIRAEAAKIT PQ
Length:462
Mass (Da):51,692
Last modified:June 1, 2001 - v1
Checksum:i47A73672270E2014
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TJY1Q3TJY1_MOUSE
Microspherule protein 1
Mcrs1
449Annotation score:
A0A2R8VJX8A0A2R8VJX8_MOUSE
Microspherule protein 1
Mcrs1
88Annotation score:
A0A2R8VH87A0A2R8VH87_MOUSE
Microspherule protein 1
Mcrs1
133Annotation score:
A0A2R8VHY8A0A2R8VHY8_MOUSE
Microspherule protein 1
Mcrs1
135Annotation score:
A0A2R8VHY5A0A2R8VHY5_MOUSE
Microspherule protein 1
Mcrs1
69Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193R → K in AAC53590 (PubMed:9654073).Curated1
Sequence conflicti274K → R in AAC53590 (PubMed:9654073).Curated1
Sequence conflicti298D → N in AAC53590 (PubMed:9654073).Curated1
Sequence conflicti314 – 315RE → QK in AAC53590 (PubMed:9654073).Curated2
Sequence conflicti368A → T in AAC53590 (PubMed:9654073).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015309 mRNA Translation: AAC53590.1
AK088116 mRNA Translation: BAC40155.1
BC003746 mRNA Translation: AAH03746.1
BC085099 mRNA Translation: AAH85099.1
BC108340 mRNA Translation: AAI08341.1
CCDSiCCDS37199.1
RefSeqiNP_001157628.1, NM_001164156.1
NP_058046.2, NM_016766.3
UniGeneiMm.383472

Genome annotation databases

EnsembliENSMUST00000041190; ENSMUSP00000043901; ENSMUSG00000037570
GeneIDi51812
KEGGimmu:51812
UCSCiuc007xpa.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015309 mRNA Translation: AAC53590.1
AK088116 mRNA Translation: BAC40155.1
BC003746 mRNA Translation: AAH03746.1
BC085099 mRNA Translation: AAH85099.1
BC108340 mRNA Translation: AAI08341.1
CCDSiCCDS37199.1
RefSeqiNP_001157628.1, NM_001164156.1
NP_058046.2, NM_016766.3
UniGeneiMm.383472

3D structure databases

ProteinModelPortaliQ99L90
SMRiQ99L90
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206187, 1 interactor
ComplexPortaliCPX-875 NSL histone acetyltransferase complex
CPX-878 INO80 chromatin remodeling complex
STRINGi10090.ENSMUSP00000043901

PTM databases

iPTMnetiQ99L90
PhosphoSitePlusiQ99L90

Proteomic databases

EPDiQ99L90
MaxQBiQ99L90
PaxDbiQ99L90
PRIDEiQ99L90

Protocols and materials databases

DNASUi51812
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041190; ENSMUSP00000043901; ENSMUSG00000037570
GeneIDi51812
KEGGimmu:51812
UCSCiuc007xpa.2 mouse

Organism-specific databases

CTDi10445
MGIiMGI:1858420 Mcrs1

Phylogenomic databases

eggNOGiKOG2293 Eukaryota
ENOG410XS0S LUCA
GeneTreeiENSGT00390000005536
HOGENOMiHOG000007227
HOVERGENiHBG052434
InParanoidiQ99L90
KOiK11674
OMAiFLVNYEL
OrthoDBiEOG091G07QN
PhylomeDBiQ99L90
TreeFamiTF318119

Enzyme and pathway databases

ReactomeiR-MMU-3214847 HATs acetylate histones
R-MMU-5689603 UCH proteinases
R-MMU-5696394 DNA Damage Recognition in GG-NER

Miscellaneous databases

PROiPR:Q99L90
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037570 Expressed in 50 organ(s), highest expression level in testis
CleanExiMM_MCRS1
ExpressionAtlasiQ99L90 baseline and differential
GenevisibleiQ99L90 MM

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR037912 MCRS1
IPR025999 MCRS_N
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR13233 PTHR13233, 1 hit
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF13325 MCRS_N, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMCRS1_MOUSE
AccessioniPrimary (citable) accession number: Q99L90
Secondary accession number(s): O35255, Q32P11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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