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Protein

Beta-1-syntrophin

Gene

Sntb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding, Calmodulin-binding
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1-syntrophin
Alternative name(s):
59 kDa dystrophin-associated protein A1 basic component 1
Short name:
DAPA1B
Syntrophin-2
Gene namesi
Name:Sntb1
Synonyms:Snt2b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:101781 Sntb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001840102 – 537Beta-1-syntrophinAdd BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei86PhosphoserineCombined sources1
Modified residuei125PhosphoserineBy similarity1
Modified residuei204PhosphoserineCombined sources1
Modified residuei213PhosphothreonineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei231PhosphoserineBy similarity1
Modified residuei235PhosphoserineCombined sources1
Modified residuei388PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CaM-kinase II.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ99L88
PeptideAtlasiQ99L88
PRIDEiQ99L88

PTM databases

iPTMnetiQ99L88
PhosphoSitePlusiQ99L88

Expressioni

Tissue specificityi

Ubiquitous. Expressed at high levels in the liver.

Gene expression databases

BgeeiENSMUSG00000060429 Expressed in 123 organ(s), highest expression level in pancreas
CleanExiMM_SNTB1
GenevisibleiQ99L88 MM

Interactioni

Subunit structurei

Monomer and homodimer (Probable). Interacts with the viral HTLV-1 TAX protein and other members of the syntrophin family: SNTA1 and SNTB2 (By similarity). Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN and with the sodium channel proteins SCN4A and SCN5A.By similarityCurated2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203383, 1 interactor
CORUMiQ99L88
IntActiQ99L88, 6 interactors
MINTiQ99L88
STRINGi10090.ENSMUSP00000041294

Structurei

3D structure databases

ProteinModelPortaliQ99L88
SMRiQ99L88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 297PH 1PROSITE-ProRule annotationAdd BLAST280
Domaini111 – 194PDZPROSITE-ProRule annotationAdd BLAST84
Domaini321 – 432PH 2PROSITE-ProRule annotationAdd BLAST112
Domaini481 – 537SUAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni517 – 537Calmodulin-bindingBy similarityAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 12Poly-AlaAdd BLAST11
Compositional biasi13 – 16Poly-Gly4

Domaini

The PH 1 domain mediates the oligomerization in a calcium dependent manner.By similarity
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity
The SU domain binds calmodulin in a calcium-dependent manner.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3551 Eukaryota
ENOG410XSII LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000231596
HOVERGENiHBG054204
InParanoidiQ99L88
OMAiCIPLKMC
OrthoDBiEOG091G0O31
PhylomeDBiQ99L88
TreeFamiTF317932

Family and domain databases

Gene3Di2.30.29.30, 3 hits
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR015482 Syntrophin
PANTHERiPTHR10554 PTHR10554, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q99L88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVAAAAVAA PAGGGGARAQ RSGLLEVLVR DRWHKVLVNL SEDALVLSCE
60 70 80 90 100
EGAAAYNGIG AATNGSFCRG SGTGHPVPGV AQAPDSPAGV RTAFTDLPEQ
110 120 130 140 150
VPESISNQKR GVKVLKQELG GLGISIKGGK ENKMPILISK IFKGLAADQT
160 170 180 190 200
QALYVGDAIL SVNGADLRDA THDEAVQALK RAGKEVLLEV KYMREATPYV
210 220 230 240 250
KKGSPVSEIG WETPPPESPR LGGGSAEPLS SQSFSFHRDR KSIPLKMCYV
260 270 280 290 300
TRNMTLADPE NRQLEIHSPD AKHTVILRSK DSATAQAWFS AIHSNAGDLL
310 320 330 340 350
TRVVADIREQ LGKTGIAGSR EIRHLGWLAE KVPGESEKQW KPALVVLTEK
360 370 380 390 400
DLLIYDSMPR RKEAWFSPVH SYPLLATRLV HSGPGKGSPQ AGMDLSFATR
410 420 430 440 450
TGTKQGIETH LFRAEISRDL SHWTRSIVQG CHNSAELTAE ITTACTYRNQ
460 470 480 490 500
ECRLTIHYDN GFSISTEPQD GAFPKTIIQS PYEKLKMSSD DGIRMLYLDF
510 520 530
GGKEGEIQLD LHSCPKPIVF IIHSFLSAKI TRLGLVA
Length:537
Mass (Da):58,081
Last modified:January 23, 2007 - v4
Checksum:i91A5E4DD0A97A665
GO
Isoform 2 (identifier: Q99L88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-276: RQLEIHSPDAKHTVI → STHPSDLIPIQGWAA
     277-537: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):28,944
Checksum:i59ED70FAE4122803
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006356262 – 276RQLEI…KHTVI → STHPSDLIPIQGWAA in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_006357277 – 537Missing in isoform 2. 1 PublicationAdd BLAST261

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89997 mRNA Translation: AAB66697.1
BC003748 mRNA Translation: AAH03748.1
CCDSiCCDS27479.1 [Q99L88-1]
RefSeqiNP_057876.1, NM_016667.3 [Q99L88-1]
XP_006520734.1, XM_006520671.3 [Q99L88-1]
UniGeneiMm.309425

Genome annotation databases

EnsembliENSMUST00000039769; ENSMUSP00000041294; ENSMUSG00000060429 [Q99L88-1]
ENSMUST00000110200; ENSMUSP00000105829; ENSMUSG00000060429 [Q99L88-2]
GeneIDi20649
KEGGimmu:20649
UCSCiuc007vsk.1 mouse [Q99L88-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89997 mRNA Translation: AAB66697.1
BC003748 mRNA Translation: AAH03748.1
CCDSiCCDS27479.1 [Q99L88-1]
RefSeqiNP_057876.1, NM_016667.3 [Q99L88-1]
XP_006520734.1, XM_006520671.3 [Q99L88-1]
UniGeneiMm.309425

3D structure databases

ProteinModelPortaliQ99L88
SMRiQ99L88
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203383, 1 interactor
CORUMiQ99L88
IntActiQ99L88, 6 interactors
MINTiQ99L88
STRINGi10090.ENSMUSP00000041294

PTM databases

iPTMnetiQ99L88
PhosphoSitePlusiQ99L88

Proteomic databases

PaxDbiQ99L88
PeptideAtlasiQ99L88
PRIDEiQ99L88

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039769; ENSMUSP00000041294; ENSMUSG00000060429 [Q99L88-1]
ENSMUST00000110200; ENSMUSP00000105829; ENSMUSG00000060429 [Q99L88-2]
GeneIDi20649
KEGGimmu:20649
UCSCiuc007vsk.1 mouse [Q99L88-1]

Organism-specific databases

CTDi6641
MGIiMGI:101781 Sntb1

Phylogenomic databases

eggNOGiKOG3551 Eukaryota
ENOG410XSII LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000231596
HOVERGENiHBG054204
InParanoidiQ99L88
OMAiCIPLKMC
OrthoDBiEOG091G0O31
PhylomeDBiQ99L88
TreeFamiTF317932

Miscellaneous databases

ChiTaRSiSntb1 mouse
PROiPR:Q99L88
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060429 Expressed in 123 organ(s), highest expression level in pancreas
CleanExiMM_SNTB1
GenevisibleiQ99L88 MM

Family and domain databases

Gene3Di2.30.29.30, 3 hits
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR015482 Syntrophin
PANTHERiPTHR10554 PTHR10554, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSNTB1_MOUSE
AccessioniPrimary (citable) accession number: Q99L88
Secondary accession number(s): O35925
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 151 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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