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Protein

V-type proton ATPase subunit C 2

Gene

Atp6v1c2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit C 2
Short name:
V-ATPase subunit C 2
Alternative name(s):
Vacuolar proton pump subunit C 2
Gene namesi
Name:Atp6v1c2
Synonyms:Atp6c2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1916025 Atp6v1c2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856701 – 427V-type proton ATPase subunit C 2Add BLAST427

Proteomic databases

PaxDbiQ99L60
PRIDEiQ99L60

PTM databases

iPTMnetiQ99L60
PhosphoSitePlusiQ99L60

Expressioni

Tissue specificityi

Predominantly expressed in the lung and kidney. Isoform 1 is lung-specific while isoform 3 is a kidney-specific isoform. Isoform 1 is localized in the lamellar bodies of type II alveolar cells. Isoform 2 is strongly expressed in the cortical and medulla collecting ducts and is found in the plasma membranes of renal alpha and beta intercalated cells.2 Publications

Developmental stagei

Significant expression seen at 17 dpc and not earlier.1 Publication

Gene expression databases

BgeeiENSMUSG00000020566 Expressed in 66 organ(s), highest expression level in prostate gland
CleanExiMM_ATP6V1C2
ExpressionAtlasiQ99L60 baseline and differential
GenevisibleiQ99L60 MM

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020884

Structurei

3D structure databases

ProteinModelPortaliQ99L60
SMRiQ99L60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase C subunit family.Curated

Phylogenomic databases

eggNOGiKOG2909 Eukaryota
COG5127 LUCA
GeneTreeiENSGT00390000004263
HOGENOMiHOG000207528
HOVERGENiHBG002470
InParanoidiQ99L60
KOiK02148
OMAiRFEWDMA
OrthoDBiEOG091G03CP
PhylomeDBiQ99L60
TreeFamiTF314912

Family and domain databases

CDDicd14785 V-ATPase_C, 1 hit
InterProiView protein in InterPro
IPR004907 ATPase_V1-cplx_csu
IPR036132 Vac_ATP_synth_c_sf
PANTHERiPTHR10137 PTHR10137, 1 hit
PfamiView protein in Pfam
PF03223 V-ATPase_C, 1 hit
SUPFAMiSSF118203 SSF118203, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q99L60-1) [UniParc]FASTAAdd to basket
Also known as: C2-a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEFWLISAP GDKENLQALE RMNNVTSKSN LSHNTKFAIP DFKVGTLDSL
60 70 80 90 100
VGLSDELGKL DTFAESLIKR MAQSVVEVME DSKGKAHETL LANGVDLTSF
110 120 130 140 150
VTHFEWDMAK YPAKQPLVSV VDTLAKQLAQ IETDLKSRTA AYSVLKANLE
160 170 180 190 200
NLEKRSTGNL FTRTLSDIVS KEDFVLDSEY LITLLVIVPK SSFAQWQKTY
210 220 230 240 250
ESLSDMVVPR STKLIAEDNE GGLFTVTLFR KVIEDFKVKA KENKFIVREF
260 270 280 290 300
YYDEKEIKRE REEMTRLLSD KKQQYPTSCV ALKKGSATYR DHKVKVAPLG
310 320 330 340 350
NPARPAAGQT DRDRESEGEG EGPLLRWLKV NFSEAFIAWI HIKALRVFVE
360 370 380 390 400
SVLRYGLPVN FQAVLLQPHK KSATKRLREV LNSVFRHLDE VAAASILDAS
410 420
VEIPGLQLSN QDYFPYVYFH IDLSLLD
Length:427
Mass (Da):48,350
Last modified:June 1, 2001 - v1
Checksum:i5D7146D9BC7F03F7
GO
Isoform 2 (identifier: Q99L60-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-95: V → GLKEKMKCLKI

Show »
Length:437
Mass (Da):49,524
Checksum:i2DAE84F4DB6006EC
GO
Isoform 3 (identifier: Q99L60-3) [UniParc]FASTAAdd to basket
Also known as: C2-b

The sequence of this isoform differs from the canonical sequence as follows:
     276-321: Missing.

Show »
Length:381
Mass (Da):43,517
Checksum:iEEC1EB557D239F62
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z5W3D3Z5W3_MOUSE
V-type proton ATPase subunit C
Atp6v1c2
357Annotation score:
D6RCW6D6RCW6_MOUSE
V-type proton ATPase subunit C
Atp6v1c2
187Annotation score:
D3Z1Q7D3Z1Q7_MOUSE
V-type proton ATPase subunit C
Atp6v1c2
134Annotation score:
D3YVW5D3YVW5_MOUSE
V-type proton ATPase subunit C
Atp6v1c2
70Annotation score:
D3YZX0D3YZX0_MOUSE
V-type proton ATPase subunit C
Atp6v1c2
63Annotation score:
A0A1Y7VLG0A0A1Y7VLG0_MOUSE
V-type proton ATPase subunit C
Atp6v1c2
102Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125A → T in AAH56636 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02488495V → GLKEKMKCLKI in isoform 2. 1 Publication1
Alternative sequenceiVSP_024885276 – 321Missing in isoform 3. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088357 mRNA Translation: BAC57950.1
BC003810 mRNA Translation: AAH03810.1
BC056636 mRNA Translation: AAH56636.1
CCDSiCCDS25827.1 [Q99L60-1]
CCDS49034.1 [Q99L60-2]
RefSeqiNP_001153104.1, NM_001159632.1 [Q99L60-2]
NP_598460.1, NM_133699.2 [Q99L60-1]
XP_006515259.1, XM_006515196.3 [Q99L60-2]
XP_006515262.1, XM_006515199.3 [Q99L60-3]
UniGeneiMm.178798

Genome annotation databases

EnsembliENSMUST00000020884; ENSMUSP00000020884; ENSMUSG00000020566 [Q99L60-2]
ENSMUST00000095820; ENSMUSP00000093500; ENSMUSG00000020566 [Q99L60-1]
ENSMUST00000221129; ENSMUSP00000152515; ENSMUSG00000020566 [Q99L60-3]
GeneIDi68775
KEGGimmu:68775
UCSCiuc007ncq.1 mouse [Q99L60-1]
uc007ncs.2 mouse [Q99L60-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVATC2_MOUSE
AccessioniPrimary (citable) accession number: Q99L60
Secondary accession number(s): Q6PHA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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