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Protein
Submitted name:

Platelet derived growth factor, alpha

Gene

Pdgfa

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-186763 Downstream signal transduction
R-MMU-186797 Signaling by PDGF
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Platelet derived growth factor, alphaImported
Submitted name:
Platelet derived growth factor, alpha, isoform CRA_bImported
Submitted name:
Platelet-derived growth factor subunit AImported
Gene namesi
Name:PdgfaImported
ORF Names:mCG_23666Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:97527 Pdgfa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501509962621 – 196Sequence analysisAdd BLAST176

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000025856 Expressed in 375 organ(s), highest expression level in skin of back

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 184PDGF_2InterPro annotationAdd BLAST102

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IEXJ Eukaryota
ENOG4111GMH LUCA
GeneTreeiENSGT00510000046755
HOGENOMiHOG000286027
HOVERGENiHBG053546
KOiK04359
TreeFamiTF319554

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR006782 PDGF_N
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
PF04692 PDGF_N, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99L56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTWACLLLL GCGYLAHALA EEAEIPRELI ERLARSQIHS IRDLQRLLEI
60 70 80 90 100
DSVGAEDALE TSLRAHGSHA INHVPEKRPV PIRRKRSIEE AIPAVCKTRT
110 120 130 140 150
VIYEIPRSQV DPTSANFLIW PPCVEVKRCT GCCNTSSVKC QPSRVHHRSV
160 170 180 190
KVAKVEYVRK KPKLKEVQVR LEEHLECACA TSNLNPDHRE EETDVR
Length:196
Mass (Da):22,281
Last modified:June 1, 2001 - v1
Checksum:i2610178FACCA3647
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P20033PDGFA_MOUSE
Platelet-derived growth factor subu...
Pdgfa
211Annotation score:
G5E891G5E891_MOUSE
Platelet derived growth factor, alp...
Pdgfa mCG_23666
211Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117698 Genomic DNA No translation available.
BC003817 mRNA Translation: AAH03817.1
CH466529 Genomic DNA Translation: EDL19179.1
RefSeqiNP_032834.1, NM_008808.3
UniGeneiMm.2675

Genome annotation databases

EnsembliENSMUST00000076095; ENSMUSP00000075463; ENSMUSG00000025856
ENSMUST00000110896; ENSMUSP00000106521; ENSMUSG00000025856
ENSMUST00000110897; ENSMUSP00000106522; ENSMUSG00000025856
GeneIDi18590
KEGGimmu:18590
UCSCiuc009afw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117698 Genomic DNA No translation available.
BC003817 mRNA Translation: AAH03817.1
CH466529 Genomic DNA Translation: EDL19179.1
RefSeqiNP_032834.1, NM_008808.3
UniGeneiMm.2675

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076095; ENSMUSP00000075463; ENSMUSG00000025856
ENSMUST00000110896; ENSMUSP00000106521; ENSMUSG00000025856
ENSMUST00000110897; ENSMUSP00000106522; ENSMUSG00000025856
GeneIDi18590
KEGGimmu:18590
UCSCiuc009afw.2 mouse

Organism-specific databases

CTDi5154
MGIiMGI:97527 Pdgfa

Phylogenomic databases

eggNOGiENOG410IEXJ Eukaryota
ENOG4111GMH LUCA
GeneTreeiENSGT00510000046755
HOGENOMiHOG000286027
HOVERGENiHBG053546
KOiK04359
TreeFamiTF319554

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-186763 Downstream signal transduction
R-MMU-186797 Signaling by PDGF
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025856 Expressed in 375 organ(s), highest expression level in skin of back

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR006782 PDGF_N
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
PF04692 PDGF_N, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ99L56_MOUSE
AccessioniPrimary (citable) accession number: Q99L56
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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