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UniProtKB - Q99L48 (NMD3_MOUSE)
Protein
60S ribosomal export protein NMD3
Gene
Nmd3
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
By similarityGO - Molecular functioni
- protein-macromolecule adaptor activity Source: MGI
- ribosomal large subunit binding Source: MGI
GO - Biological processi
- positive regulation of protein binding Source: MGI
- positive regulation of protein localization to nucleolus Source: MGI
- positive regulation of RNA biosynthetic process Source: MGI
- protein transport Source: UniProtKB-KW
- ribosomal large subunit export from nucleus Source: MGI
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal export protein NMD3 |
Gene namesi | Name:Nmd3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2140103, Nmd3 |
VEuPathDBi | HostDB:ENSMUSG00000027787 |
Subcellular locationi
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000323562 | 1 – 503 | 60S ribosomal export protein NMD3Add BLAST | 503 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 258 | PhosphoserineBy similarity | 1 | |
Modified residuei | 433 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 468 | PhosphoserineCombined sources | 1 | |
Modified residuei | 470 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q99L48 |
jPOSTi | Q99L48 |
MaxQBi | Q99L48 |
PaxDbi | Q99L48 |
PeptideAtlasi | Q99L48 |
PRIDEi | Q99L48 |
ProteomicsDBi | 293862 [Q99L48-1] 293863 [Q99L48-2] |
PTM databases
iPTMneti | Q99L48 |
PhosphoSitePlusi | Q99L48 |
SwissPalmi | Q99L48 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027787, Expressed in female gonad and 307 other tissues |
Genevisiblei | Q99L48, MM |
Interactioni
Subunit structurei
Found in a 60S ribosomal subunit export complex with RAN and XPO1.
Interacts with XPO1. Associates with the 60S ribosomal subunit (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 220607, 1 interactor |
STRINGi | 10090.ENSMUSP00000029358 |
Miscellaneous databases
RNActi | Q99L48, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 425 – 503 | Necessary for the nuclear export of the 60S ribosomal subunitBy similarityAdd BLAST | 79 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 405 – 422 | Nuclear and nucleolar localization signalBy similarityAdd BLAST | 18 | |
Motifi | 480 – 489 | Nuclear export signalBy similarity | 10 |
Sequence similaritiesi
Belongs to the NMD3 family.Curated
Phylogenomic databases
eggNOGi | KOG2613, Eukaryota |
GeneTreei | ENSGT00390000005104 |
HOGENOMi | CLU_027444_2_0_1 |
InParanoidi | Q99L48 |
OMAi | CERWLQP |
OrthoDBi | 734666at2759 |
PhylomeDBi | Q99L48 |
TreeFami | TF105744 |
Family and domain databases
InterProi | View protein in InterPro IPR039768, Nmd3 IPR007064, Nmd3_N |
PANTHERi | PTHR12746, PTHR12746, 1 hit |
Pfami | View protein in Pfam PF04981, NMD3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q99L48-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEYMAESIEH SPGHILCCEC GVPISPNPAN ICVACLRSKV DISQGVPKQV
60 70 80 90 100
SISFCKQCQR YFQPPASWVQ CALESRELLA LCLKKIKAPL SKVRLVDAGF
110 120 130 140 150
VWTEPHSKRL KVKLTIQKEV MNGAILQQVF VVDYVVQSQM CGDCHRVEAK
160 170 180 190 200
DFWKAVIQVR QKTLHKKTFY YLEQLILKYG MHQNTLRIKE IHDGLDFYYS
210 220 230 240 250
SKQHAQKMVE FLQGIVPCRY KASQRLISQD IHSNTYNYKS TFSVEIVPIC
260 270 280 290 300
KDNVVCLSPK LAQSLGNMSQ ICICIRVTSA IHLIDPNTLQ VADIDGNTFW
310 320 330 340 350
SHPFNSLCHP KQLEEFIVIE CSTVRDLKRS AGAGVISKKH TLGEVWIQKT
360 370 380 390 400
SEMNTDKQYF CRTHLGHLLN PGDLVLGFDL ANCNLNDEYV NKMNSDRVPD
410 420 430 440 450
VVLIKKSYDR TKRQRRRNWK LKELARDREN MDTDDERQYQ DFLEDLEEDE
460 470 480 490 500
AIRKHVNIYR DATIPVESDT DDEGAPRISL AEMLEDLHIS QDATGEEGAS
MMS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YYX2 | D3YYX2_MOUSE | 60S ribosomal export protein NMD3 | Nmd3 | 76 | Annotation score: | ||
A0A0A6YY59 | A0A0A6YY59_MOUSE | 60S ribosomal export protein NMD3 | Nmd3 | 144 | Annotation score: | ||
D6RHT4 | D6RHT4_MOUSE | 60S ribosomal export protein NMD3 | Nmd3 | 36 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032020 | 193 – 200 | DGLDFYYS → GEFKFKRI in isoform 2. 1 Publication | 8 | |
Alternative sequenceiVSP_032021 | 201 – 503 | Missing in isoform 2. 1 PublicationAdd BLAST | 303 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK034772 mRNA Translation: BAC28829.1 AK088667 mRNA Translation: BAC40491.1 AK143289 mRNA Translation: BAE25334.1 AK145248 mRNA Translation: BAE26326.1 AK166283 mRNA Translation: BAE38680.1 BC003842 mRNA Translation: AAH03842.1 |
CCDSi | CCDS17407.1 [Q99L48-1] |
RefSeqi | NP_598548.1, NM_133787.2 [Q99L48-1] |
Genome annotation databases
Ensembli | ENSMUST00000029358; ENSMUSP00000029358; ENSMUSG00000027787 [Q99L48-1] |
GeneIDi | 97112 |
KEGGi | mmu:97112 |
UCSCi | uc008pmk.1, mouse [Q99L48-2] uc008pml.1, mouse [Q99L48-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK034772 mRNA Translation: BAC28829.1 AK088667 mRNA Translation: BAC40491.1 AK143289 mRNA Translation: BAE25334.1 AK145248 mRNA Translation: BAE26326.1 AK166283 mRNA Translation: BAE38680.1 BC003842 mRNA Translation: AAH03842.1 |
CCDSi | CCDS17407.1 [Q99L48-1] |
RefSeqi | NP_598548.1, NM_133787.2 [Q99L48-1] |
3D structure databases
SMRi | Q99L48 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 220607, 1 interactor |
STRINGi | 10090.ENSMUSP00000029358 |
PTM databases
iPTMneti | Q99L48 |
PhosphoSitePlusi | Q99L48 |
SwissPalmi | Q99L48 |
Proteomic databases
EPDi | Q99L48 |
jPOSTi | Q99L48 |
MaxQBi | Q99L48 |
PaxDbi | Q99L48 |
PeptideAtlasi | Q99L48 |
PRIDEi | Q99L48 |
ProteomicsDBi | 293862 [Q99L48-1] 293863 [Q99L48-2] |
Protocols and materials databases
Antibodypediai | 33677, 128 antibodies from 27 providers |
DNASUi | 97112 |
Genome annotation databases
Ensembli | ENSMUST00000029358; ENSMUSP00000029358; ENSMUSG00000027787 [Q99L48-1] |
GeneIDi | 97112 |
KEGGi | mmu:97112 |
UCSCi | uc008pmk.1, mouse [Q99L48-2] uc008pml.1, mouse [Q99L48-1] |
Organism-specific databases
CTDi | 51068 |
MGIi | MGI:2140103, Nmd3 |
VEuPathDBi | HostDB:ENSMUSG00000027787 |
Phylogenomic databases
eggNOGi | KOG2613, Eukaryota |
GeneTreei | ENSGT00390000005104 |
HOGENOMi | CLU_027444_2_0_1 |
InParanoidi | Q99L48 |
OMAi | CERWLQP |
OrthoDBi | 734666at2759 |
PhylomeDBi | Q99L48 |
TreeFami | TF105744 |
Miscellaneous databases
BioGRID-ORCSi | 97112, 24 hits in 63 CRISPR screens |
PROi | PR:Q99L48 |
RNActi | Q99L48, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027787, Expressed in female gonad and 307 other tissues |
Genevisiblei | Q99L48, MM |
Family and domain databases
InterProi | View protein in InterPro IPR039768, Nmd3 IPR007064, Nmd3_N |
PANTHERi | PTHR12746, PTHR12746, 1 hit |
Pfami | View protein in Pfam PF04981, NMD3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NMD3_MOUSE | |
Accessioni | Q99L48Primary (citable) accession number: Q99L48 Secondary accession number(s): Q3UPR1, Q8BM61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families