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Protein

Phosphatidate cytidylyltransferase 2

Gene

Cds2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.By similarity

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), Glycerol-3-phosphate acyltransferase 3 (Gpat3), Glycerol-3-phosphate acyltransferase 2, mitochondrial (Gpat2), Glycerol-3-phosphate acyltransferase 4 (Gpat4)
  2. Lysocardiolipin acyltransferase 1 (Lclat1), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (Agpat4), 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (Agpat5), 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (Agpat3), 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (Agpat1), 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (Agpat2)
  3. Phosphatidate cytidylyltransferase, mitochondrial (Tamm41), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase, mitochondrial (Tamm41), Phosphatidate cytidylyltransferase 1 (Cds1), Phosphatidate cytidylyltransferase 2 (Cds2), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase (Cds2)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

  • CDP-diacylglycerol biosynthetic process Source: GO_Central
  • glycosylation Source: BHF-UCL
  • phosphatidylglycerol biosynthetic process Source: GO_Central
  • phototransduction Source: BHF-UCL

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BRENDAi2.7.7.41 3474
ReactomeiR-MMU-1483148 Synthesis of PG
UniPathwayi
UPA00557;UER00614

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase 2 (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase 2
CDP-DG synthase 2
CDP-diacylglycerol synthase 2
Short name:
CDS 2
CDP-diglyceride pyrophosphorylase 2
CDP-diglyceride synthase 2
CTP:phosphatidate cytidylyltransferase 2
Gene namesi
Name:Cds2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1332236 Cds2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907171 – 444Phosphatidate cytidylyltransferase 2Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineBy similarity1
Modified residuei30PhosphothreonineBy similarity1
Modified residuei32PhosphoserineCombined sources1
Modified residuei34PhosphoserineBy similarity1
Modified residuei36PhosphoserineCombined sources1
Modified residuei50PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99L43
MaxQBiQ99L43
PaxDbiQ99L43
PeptideAtlasiQ99L43
PRIDEiQ99L43

PTM databases

iPTMnetiQ99L43
PhosphoSitePlusiQ99L43
SwissPalmiQ99L43

Expressioni

Gene expression databases

BgeeiENSMUSG00000058793 Expressed in 296 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ99L43 baseline and differential
GenevisibleiQ99L43 MM

Interactioni

Protein-protein interaction databases

BioGridi226008, 2 interactors
IntActiQ99L43, 1 interactor
MINTiQ99L43
STRINGi10090.ENSMUSP00000099470

Structurei

3D structure databases

ProteinModelPortaliQ99L43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1440 Eukaryota
COG0575 LUCA
GeneTreeiENSGT00390000016175
HOGENOMiHOG000209582
HOVERGENiHBG002485
InParanoidiQ99L43
KOiK00981
OMAiREVAIMP
OrthoDBiEOG091G06CA
PhylomeDBiQ99L43
TreeFamiTF313464

Family and domain databases

InterProiView protein in InterPro
IPR000374 PC_trans
IPR016720 PC_Trfase_euk
PIRSFiPIRSF018269 PC_trans_euk, 1 hit
PROSITEiView protein in PROSITE
PS01315 CDS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q99L43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTELRQRVVR EDAPPEDKES ESEAKLDGET ASDSESRAET APLPTSVDDT
60 70 80 90 100
PEVLNRALSN LSSRWKNWWV RGILTLAMIA FFFIIIYLGP MVLMMIVMCV
110 120 130 140 150
QIKCFHEIIT IGYNVYHSYD LPWFRTLSWY FLLCVNYFFY GETVTDYFFT
160 170 180 190 200
LVQREEPLRI LSKYHRFISF ALYLTGFCMF VLSLVKKHYR LQFYMFGWTH
210 220 230 240 250
VTLLIVVTQS HLVIHNLFEG MIWFIVPISC VICNDIMAYM FGFFFGRTPL
260 270 280 290 300
IKLSPKKTWE GFIGGFFATV VFGLLLSYVM SGYRCFVCPV EYNNDTNSFT
310 320 330 340 350
VDCEPSDLFR LQEYNIPGVI QSAIGWKTVR MYPFQIHSIA LSTFASLIGP
360 370 380 390 400
FGGFFASGFK RAFKIKDFAN TIPGHGGIMD RFDCQYLMAT FVNVYIASFI
410 420 430 440
RGPNPSKLIQ QFLTLRPDQQ LHIFNTLKSH LTDKGILTSA LEDE
Length:444
Mass (Da):51,314
Last modified:June 1, 2001 - v1
Checksum:i6A3568A7E90A6C53
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AMQ5A2AMQ5_MOUSE
Phosphatidate cytidylyltransferase
Cds2
427Annotation score:
F6S4G2F6S4G2_MOUSE
Phosphatidate cytidylyltransferase
Cds2
194Annotation score:
Q6PBC0Q6PBC0_MOUSE
Cds2 protein
Cds2
129Annotation score:
H3BLA1H3BLA1_MOUSE
Phosphatidate cytidylyltransferase ...
Cds2
33Annotation score:
H3BKR7H3BKR7_MOUSE
Phosphatidate cytidylyltransferase ...
Cds2
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43L → P in AAH69879 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY159802 mRNA Translation: AAO17790.1
AK036328 mRNA Translation: BAC29384.1
AK147541 mRNA Translation: BAE27984.1
AK166001 mRNA Translation: BAE38511.1
BC003852 mRNA Translation: AAH03852.1
BC069879 mRNA Translation: AAH69879.1
CCDSiCCDS16772.1
RefSeqiNP_001277968.1, NM_001291039.1
NP_619592.1, NM_138651.7
UniGeneiMm.284503

Genome annotation databases

EnsembliENSMUST00000103181; ENSMUSP00000099470; ENSMUSG00000058793
GeneIDi110911
KEGGimmu:110911
UCSCiuc008mmo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY159802 mRNA Translation: AAO17790.1
AK036328 mRNA Translation: BAC29384.1
AK147541 mRNA Translation: BAE27984.1
AK166001 mRNA Translation: BAE38511.1
BC003852 mRNA Translation: AAH03852.1
BC069879 mRNA Translation: AAH69879.1
CCDSiCCDS16772.1
RefSeqiNP_001277968.1, NM_001291039.1
NP_619592.1, NM_138651.7
UniGeneiMm.284503

3D structure databases

ProteinModelPortaliQ99L43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi226008, 2 interactors
IntActiQ99L43, 1 interactor
MINTiQ99L43
STRINGi10090.ENSMUSP00000099470

PTM databases

iPTMnetiQ99L43
PhosphoSitePlusiQ99L43
SwissPalmiQ99L43

Proteomic databases

EPDiQ99L43
MaxQBiQ99L43
PaxDbiQ99L43
PeptideAtlasiQ99L43
PRIDEiQ99L43

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103181; ENSMUSP00000099470; ENSMUSG00000058793
GeneIDi110911
KEGGimmu:110911
UCSCiuc008mmo.2 mouse

Organism-specific databases

CTDi8760
MGIiMGI:1332236 Cds2

Phylogenomic databases

eggNOGiKOG1440 Eukaryota
COG0575 LUCA
GeneTreeiENSGT00390000016175
HOGENOMiHOG000209582
HOVERGENiHBG002485
InParanoidiQ99L43
KOiK00981
OMAiREVAIMP
OrthoDBiEOG091G06CA
PhylomeDBiQ99L43
TreeFamiTF313464

Enzyme and pathway databases

UniPathwayi
UPA00557;UER00614

BRENDAi2.7.7.41 3474
ReactomeiR-MMU-1483148 Synthesis of PG

Miscellaneous databases

ChiTaRSiCds2 mouse
PROiPR:Q99L43
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058793 Expressed in 296 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ99L43 baseline and differential
GenevisibleiQ99L43 MM

Family and domain databases

InterProiView protein in InterPro
IPR000374 PC_trans
IPR016720 PC_Trfase_euk
PIRSFiPIRSF018269 PC_trans_euk, 1 hit
PROSITEiView protein in PROSITE
PS01315 CDS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDS2_MOUSE
AccessioniPrimary (citable) accession number: Q99L43
Secondary accession number(s): Q3TMD1, Q6NSU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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