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Protein

GMP reductase 2

Gene

Gmpr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity).UniRule annotationBy similarity

Catalytic activityi

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78NADPUniRule annotation1
Metal bindingi181Potassium; via carbonyl oxygenUniRule annotation1
Metal bindingi183Potassium; via carbonyl oxygenUniRule annotation1
Active sitei186Thioimidate intermediateUniRule annotation1
Metal bindingi186Potassium; via carbonyl oxygenUniRule annotation1
Active sitei188Proton donor/acceptorUniRule annotation1
Metal bindingi189PotassiumUniRule annotation1
Binding sitei269NADP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 27NADP; shared with neighboring subunitUniRule annotation2
Nucleotide bindingi129 – 131NADPUniRule annotation3
Nucleotide bindingi180 – 181NADPUniRule annotation2
Nucleotide bindingi285 – 286NADPUniRule annotation2
Nucleotide bindingi314 – 317NADP; shared with neighboring subunitUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPurine metabolism
LigandMetal-binding, NADP, Potassium

Enzyme and pathway databases

ReactomeiR-MMU-74217 Purine salvage

Names & Taxonomyi

Protein namesi
Recommended name:
GMP reductase 2UniRule annotation (EC:1.7.1.7UniRule annotation)
Short name:
GMPR 2UniRule annotation
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase 2UniRule annotation
Short name:
Guanosine monophosphate reductase 2UniRule annotation
Gene namesi
Name:Gmpr2UniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1917903 Gmpr2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000937271 – 348GMP reductase 2Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei291N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99L27
MaxQBiQ99L27
PaxDbiQ99L27
PeptideAtlasiQ99L27
PRIDEiQ99L27

PTM databases

iPTMnetiQ99L27
PhosphoSitePlusiQ99L27

Expressioni

Gene expression databases

BgeeiENSMUSG00000002326 Expressed in 277 organ(s), highest expression level in dorsal pancreas
CleanExiMM_GMPR2
GenevisibleiQ99L27 MM

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002397

Structurei

3D structure databases

ProteinModelPortaliQ99L27
SMRiQ99L27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 221GMP bindingUniRule annotation3
Regioni242 – 243GMP bindingUniRule annotation2
Regioni268 – 270GMP bindingUniRule annotation3
Regioni286 – 290GMP bindingUniRule annotation5

Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2550 Eukaryota
COG0516 LUCA
GeneTreeiENSGT00530000062923
HOGENOMiHOG000165756
HOVERGENiHBG051744
InParanoidiQ99L27
KOiK00364
OMAiAKVLCKF
OrthoDBiEOG091G09KQ
TreeFamiTF300378

Family and domain databases

CDDicd00381 IMPDH, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00596 GMP_reduct_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR005993 GMPR
IPR015875 IMP_DH/GMP_Rdtase_CS
IPR001093 IMP_DH_GMPRt
PfamiView protein in Pfam
PF00478 IMPDH, 1 hit
PIRSFiPIRSF000235 GMP_reductase, 1 hit
TIGRFAMsiTIGR01305 GMP_reduct_1, 1 hit
PROSITEiView protein in PROSITE
PS00487 IMP_DH_GMP_RED, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q99L27-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV ELTRSFSFRN SKQMYSGIPV
60 70 80 90 100
IAANMDTVGT FEMARVLCKF SLFTAIHKHY SIHQWQEFAS QNPDCLECLA
110 120 130 140 150
ASSGSGSADF EQLEQILEAI PQVKYICLDV ANGYSEHFVE FVKDVRKRFP
160 170 180 190 200
QHTIMAGNVV TGEMVEELIL SGADIIKVGI GPGSVCTTRK KTGVGYPQLS
210 220 230 240 250
AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM LGGMLAGHSE
260 270 280 290 300
SGGELIERDG KKYKLFYGMS SEMAMKKYSG GVAEYRASEG KIVEVPFKGD
310 320 330 340
VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSNSQ
Length:348
Mass (Da):38,019
Last modified:July 27, 2011 - v2
Checksum:i83E6998193D22FC0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRT9A0A2I3BRT9_MOUSE
GMP reductase 2
Gmpr2
96Annotation score:
A0A2I3BQX8A0A2I3BQX8_MOUSE
GMP reductase 2
Gmpr2
218Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105S → T in AAH03886 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031004 mRNA Translation: BAC27211.1
AK075772 mRNA Translation: BAC35946.1
CH466535 Genomic DNA Translation: EDL36258.1
BC003886 mRNA Translation: AAH03886.1
BC024109 mRNA Translation: AAH24109.1
CCDSiCCDS27124.1
RefSeqiNP_818773.1, NM_177992.2
XP_006518429.1, XM_006518366.1
UniGeneiMm.390685
Mm.486705

Genome annotation databases

EnsembliENSMUST00000002397; ENSMUSP00000002397; ENSMUSG00000002326
GeneIDi105446
KEGGimmu:105446
UCSCiuc007uae.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGMPR2_MOUSE
AccessioniPrimary (citable) accession number: Q99L27
Secondary accession number(s): Q542X2, Q8R1T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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