UniProtKB - Q99L02 (PGR1A_MOUSE)
PAXIP1-associated glutamate-rich protein 1A
Pagr1a
Functioni
Caution
GO - Molecular functioni
- estrogen receptor binding Source: MGI
GO - Biological processi
- chorion development Source: MGI
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- histone H3-K27 demethylation Source: MGI
- histone H3-K4 methylation Source: GO_Central
- positive regulation of cell cycle G1/S phase transition Source: MGI
- positive regulation of intracellular estrogen receptor signaling pathway Source: MGI
- positive regulation of isotype switching to IgG isotypes Source: UniProtKB
- positive regulation of response to DNA damage stimulus Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of cell cycle G2/M phase transition Source: UniProtKB
Keywordsi
Biological process | DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: PAXIP1-associated glutamate-rich protein 1AImportedAlternative name(s): PAXIP1-associated protein 1 PTIP-associated protein 1 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914528, Pagr1a |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- histone methyltransferase complex Source: MGI
- MLL3/4 complex Source: MGI
- nucleoplasm Source: Reactome
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000248335 | 1 – 253 | PAXIP1-associated glutamate-rich protein 1ACuratedAdd BLAST | 253 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 137 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 142 | PhosphoserineBy similarity | 1 | |
Modified residuei | 147 | PhosphoserineBy similarity | 1 | |
Modified residuei | 236 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q99L02 |
jPOSTi | Q99L02 |
MaxQBi | Q99L02 |
PaxDbi | Q99L02 |
PeptideAtlasi | Q99L02 |
PRIDEi | Q99L02 |
PTM databases
iPTMneti | Q99L02 |
PhosphoSitePlusi | Q99L02 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000030680, Expressed in forelimb bud and 53 other tissues |
Genevisiblei | Q99L02, MM |
Interactioni
Subunit structurei
Component of the KMT2 family MLL2/MLL3 complex, at least composed of the histone methyltransferases KMT2D and/or KMT2C, the common subunits ASH2L, RBBP5, WDR5 and DPY30, and the complex type-specific subunits PAXIP1/PTIP, PAGR1, NCOA6 and KDM6A; PAXIP1 is required for the association with the MLL2/MLL3 complex (By similarity).
Forms a constitutive complex with PAXIP1/PTIP independently of the MLL2/MLL3 complex (PubMed:19124460, PubMed:26744420).
Interacts with NCOA1, ESR1, NR3C1, AR (By similarity).
By similarity2 PublicationsBinary interactionsi
Q99L02
With | #Exp. | IntAct |
---|---|---|
Paxip1 [Q6NZQ4] | 11 | EBI-11667455,EBI-1395317 |
GO - Molecular functioni
- estrogen receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 212067, 3 interactors |
IntActi | Q99L02, 1 interactor |
STRINGi | 10090.ENSMUSP00000032918 |
Miscellaneous databases
RNActi | Q99L02, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 115 – 159 | Sufficient for interaction with NCOA1By similarityAdd BLAST | 45 | |
Regioni | 160 – 253 | Sufficient for interaction with ESR1By similarityAdd BLAST | 94 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 47 – 159 | Glu-richAdd BLAST | 113 |
Phylogenomic databases
eggNOGi | ENOG502S0T8, Eukaryota |
GeneTreei | ENSGT00390000016049 |
HOGENOMi | CLU_088613_1_0_1 |
InParanoidi | Q99L02 |
OMAi | QAWMPPP |
OrthoDBi | 1630689at2759 |
PhylomeDBi | Q99L02 |
TreeFami | TF326621 |
Family and domain databases
InterProi | View protein in InterPro IPR028213, PA1 |
PANTHERi | PTHR28467, PTHR28467, 1 hit |
Pfami | View protein in Pfam PF15364, PAXIP1_C, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSLALGHGTI AGSTAAPLSE EGEVTSGLQA LAVEDTGGPS VSASKAEEEG
60 70 80 90 100
KGSQEEAGRE GSRPEEALEA PSAASDERAE GEAEDWCVPC SDEEVELPAN
110 120 130 140 150
GQSWMPPPSE IQRLYELLAT QGTLELQAEI LPRRPPTPEA QSEEERSDEE
160 170 180 190 200
PEAKEEEEEK PHMPTEFDFD DEPMTPKDSL IDRRRTPGSS ARSQKREARL
210 220 230 240 250
DKVLSDMKRH KKLEEQILRT GRDLFSLDSE GPSPTSPPLR SSGNSLFPRQ
RKY
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3UZB0 | G3UZB0_MOUSE | PAXIP1-associated glutamate-rich pr... | Pagr1a | 91 | Annotation score: | ||
A0A0J9YUB4 | A0A0J9YUB4_MOUSE | Predicted gene 42742 | Gm42742 | 176 | Annotation score: | ||
A0A0U1RQA9 | A0A0U1RQA9_MOUSE | PAXIP1-associated glutamate-rich pr... | Pagr1a | 135 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK082775 mRNA Translation: BAC38614.1 BC003932 mRNA Translation: AAH03932.1 |
CCDSi | CCDS21854.1 |
RefSeqi | NP_084516.1, NM_030240.1 |
Genome annotation databases
Ensembli | ENSMUST00000200948; ENSMUSP00000144469; ENSMUSG00000030680 ENSMUST00000202798; ENSMUSP00000144243; ENSMUSG00000107068 |
GeneIDi | 67278 |
KEGGi | mmu:67278 |
UCSCi | uc009jtx.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK082775 mRNA Translation: BAC38614.1 BC003932 mRNA Translation: AAH03932.1 |
CCDSi | CCDS21854.1 |
RefSeqi | NP_084516.1, NM_030240.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 212067, 3 interactors |
IntActi | Q99L02, 1 interactor |
STRINGi | 10090.ENSMUSP00000032918 |
PTM databases
iPTMneti | Q99L02 |
PhosphoSitePlusi | Q99L02 |
Proteomic databases
EPDi | Q99L02 |
jPOSTi | Q99L02 |
MaxQBi | Q99L02 |
PaxDbi | Q99L02 |
PeptideAtlasi | Q99L02 |
PRIDEi | Q99L02 |
Genome annotation databases
Ensembli | ENSMUST00000200948; ENSMUSP00000144469; ENSMUSG00000030680 ENSMUST00000202798; ENSMUSP00000144243; ENSMUSG00000107068 |
GeneIDi | 67278 |
KEGGi | mmu:67278 |
UCSCi | uc009jtx.1, mouse |
Organism-specific databases
CTDi | 67278 |
MGIi | MGI:1914528, Pagr1a |
Phylogenomic databases
eggNOGi | ENOG502S0T8, Eukaryota |
GeneTreei | ENSGT00390000016049 |
HOGENOMi | CLU_088613_1_0_1 |
InParanoidi | Q99L02 |
OMAi | QAWMPPP |
OrthoDBi | 1630689at2759 |
PhylomeDBi | Q99L02 |
TreeFami | TF326621 |
Miscellaneous databases
BioGRID-ORCSi | 67278, 5 hits in 18 CRISPR screens |
ChiTaRSi | Pagr1a, mouse |
PROi | PR:Q99L02 |
RNActi | Q99L02, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030680, Expressed in forelimb bud and 53 other tissues |
Genevisiblei | Q99L02, MM |
Family and domain databases
InterProi | View protein in InterPro IPR028213, PA1 |
PANTHERi | PTHR28467, PTHR28467, 1 hit |
Pfami | View protein in Pfam PF15364, PAXIP1_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PGR1A_MOUSE | |
Accessioni | Q99L02Primary (citable) accession number: Q99L02 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot