Bombesin receptor-activated protein C6orf89 homolog

Functionⁱ

Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells.By similarity

GO - Biological processⁱ

epithelial cell proliferation Source: UniProtKB
positive regulation of cell cycle Source: UniProtKB
positive regulation of histone deacetylase activity Source: UniProtKB
wound healing Source: UniProtKB

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Bombesin receptor-activated protein C6orf89 homolog
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:2136782 BC004004

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 58	CytoplasmicCuratedAdd BLAST	58
Transmembraneⁱ	59 – 79	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	80 – 348	ExtracellularCuratedAdd BLAST	269

Keywords - Cellular componentⁱ

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000237622	1 – 348	Bombesin receptor-activated protein C6orf89 homologAdd BLAST		348

Post-translational modificationⁱ

Glycosylated.By similarity

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q99KU6
PRIDEⁱ	Q99KU6

PTM databases

iPTMnetⁱ	Q99KU6
PhosphoSitePlusⁱ	Q99KU6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000052712 Expressed in 287 organ(s), highest expression level in pituitary gland
CleanExⁱ	MM_BC004004
Genevisibleⁱ	Q99KU6 MM

Interactionⁱ

Subunit structureⁱ

Homodimer (By similarity). Interacts with BRS3. Interacts (via N-terminus) with SIN3B.By similarity

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99KU6
SMRⁱ	Q99KU6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IE6D Eukaryota ENOG410YJCN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014270
HOGENOMⁱ	HOG000070100
HOVERGENⁱ	HBG055530
InParanoidⁱ	Q99KU6
OMAⁱ	RMHDLFT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G097D
PhylomeDBⁱ	Q99KU6
TreeFamⁱ	TF335525

Family and domain databases

InterProⁱ	View protein in InterPro IPR038757 BRAP
PANTHERⁱ	PTHR35259 PTHR35259, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q99KU6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDLAANEISI YDKLSETVDL VRQTGHQCGM SEKAIEKFIR QLLEKNEPQR 
        60         70         80         90        100
GPPQYPLLIA VYKVLLTLGL ILFTAYFVIQ PFSSLAPEPV LSGANSWRSL 
       110        120        130        140        150
VHHIRLVSLP ITKKYMPENK GVPLQGSQED KPFPDFDPWS SYNCEQNESE 
       160        170        180        190        200
PIPANCTGCA QILPLKVTLP EDTPKNFERL RPLVIKTGQP LSSAEIQSFS 
       210        220        230        240        250
CQYPEVTEGF TEGFFTKWWR CFPERWFPFP YPWRRPLNRS QILRELFPVF 
       260        270        280        290        300
TQLPFPKDSS LNKCFLIQPE PVVGSKMHKV HDLFTLGSGE AMLQLIPPFQ 
       310        320        330        340 
CRTHCQSVAM PIESGDIGYA DAAHWKVYIV ARGVQPLVIC DGTTLSDL

Length:348

Mass (Da):39,486

Last modified:May 30, 2006 - v2

Checksum:ⁱ4DC5F56EACB84759

GO

Sequence cautionⁱ

The sequence AAP45201 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	190	P → S in AAH58575 (PubMed:15489334).Curated	1
Sequence conflictⁱ	198	S → G in AAP45198 (PubMed:15489334).Curated	1
Sequence conflictⁱ	347	D → E in AAP45198 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY301264 Genomic DNA Translation: AAP45198.1 AY301264 Genomic DNA Translation: AAP45201.1 Sequence problems. BC004004 mRNA Translation: AAH04004.1 BC058575 mRNA Translation: AAH58575.1 AK030596 mRNA Translation: BAC27038.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28594.1
UniGeneⁱ	Mm.290116

Genome annotation databases

Ensemblⁱ	ENSMUST00000064709; ENSMUSP00000066224; ENSMUSG00000052712 ENSMUST00000120346; ENSMUSP00000113315; ENSMUSG00000052712 ENSMUST00000149405; ENSMUSP00000117309; ENSMUSG00000052712
GeneIDⁱ	80748
KEGGⁱ	mmu:80748
UCSC genome browser More...UCSCⁱ	uc008bsn.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99KU6	Uncharacterized protein (Fragment)		MOUSE		59	UniRef100_Q99KU6
UPI00001EB83C		MOUSE		355

Protein	Similar proteins		Species	Score	Length	Source
Q99KU6	Uncharacterized protein (Fragment)		MOUSE		59	UniRef90_Q99KU6
UPI00001EB83C		MOUSE		355

Protein	Similar proteins		Species	Score	Length	Source
Q99KU6	Uncharacterized protein (Fragment)		MOUSE		59	UniRef50_Q99KU6
Chromosome 23 C6orf89 homolog		BOVIN		348
Uncharacterized protein (Fragment)		wild yak		354
Uncharacterized protein		SHEEP		354
bombesin receptor-activated protein C6orf89 homolog isoform X2		Florida manatee		348
+38

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY301264 Genomic DNA Translation: AAP45198.1 AY301264 Genomic DNA Translation: AAP45201.1 Sequence problems. BC004004 mRNA Translation: AAH04004.1 BC058575 mRNA Translation: AAH58575.1 AK030596 mRNA Translation: BAC27038.1
CCDSⁱ	CCDS28594.1
UniGeneⁱ	Mm.290116

3D structure databases

ProteinModelPortalⁱ	Q99KU6
SMRⁱ	Q99KU6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

iPTMnetⁱ	Q99KU6
PhosphoSitePlusⁱ	Q99KU6

Proteomic databases

PaxDbⁱ	Q99KU6
PRIDEⁱ	Q99KU6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000064709; ENSMUSP00000066224; ENSMUSG00000052712 ENSMUST00000120346; ENSMUSP00000113315; ENSMUSG00000052712 ENSMUST00000149405; ENSMUSP00000117309; ENSMUSG00000052712
GeneIDⁱ	80748
KEGGⁱ	mmu:80748
UCSCⁱ	uc008bsn.2 mouse

Organism-specific databases

MGIⁱ	MGI:2136782 BC004004

Phylogenomic databases

eggNOGⁱ	ENOG410IE6D Eukaryota ENOG410YJCN LUCA
GeneTreeⁱ	ENSGT00390000014270
HOGENOMⁱ	HOG000070100
HOVERGENⁱ	HBG055530
InParanoidⁱ	Q99KU6
OMAⁱ	RMHDLFT
OrthoDBⁱ	EOG091G097D
PhylomeDBⁱ	Q99KU6
TreeFamⁱ	TF335525

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q99KU6

PROⁱ

PR:Q99KU6

Gene expression databases

Bgeeⁱ	ENSMUSG00000052712 Expressed in 287 organ(s), highest expression level in pituitary gland
CleanExⁱ	MM_BC004004
Genevisibleⁱ	Q99KU6 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR038757 BRAP
PANTHERⁱ	PTHR35259 PTHR35259, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CF089_MOUSE
Accessionⁱ	Q99KU6Primary (citable) accession number: Q99KU6 Secondary accession number(s): Q6PDQ4 , Q7TSE2, Q7TSE4, Q8BST4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
	Last sequence update:	May 30, 2006
	Last modified:	November 7, 2018
	This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99KU6 (CF089_MOUSE)

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Bombesin receptor-activated protein C6orf89 homolog

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Other locations

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ