UniProtKB - Q99KU6 (CF089_MOUSE)
Protein
Bombesin receptor-activated protein C6orf89 homolog
Gene
N/A
Organism
Mus musculus (Mouse)
Status
Functioni
Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells.By similarity
GO - Biological processi
- epithelial cell proliferation Source: UniProtKB
- positive regulation of cell cycle Source: UniProtKB
- positive regulation of histone deacetylase activity Source: UniProtKB
- wound healing Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Bombesin receptor-activated protein C6orf89 homolog |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2136782, BC004004 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Single-pass type II membrane protein By similarity
Other locations
- Cytoplasm By similarity
Golgi apparatus
- Golgi membrane Source: UniProtKB
Nucleus
- nucleolus Source: MGI
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- midbody Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 58 | CytoplasmicCuratedAdd BLAST | 58 | |
Transmembranei | 59 – 79 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 80 – 348 | ExtracellularCuratedAdd BLAST | 269 |
Keywords - Cellular componenti
Cytoplasm, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000237622 | 1 – 348 | Bombesin receptor-activated protein C6orf89 homologAdd BLAST | 348 |
Post-translational modificationi
Glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q99KU6 |
PaxDbi | Q99KU6 |
PRIDEi | Q99KU6 |
PTM databases
iPTMneti | Q99KU6 |
PhosphoSitePlusi | Q99KU6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000052712, Expressed in pituitary gland and 304 other tissues |
ExpressionAtlasi | Q99KU6, baseline and differential |
Genevisiblei | Q99KU6, MM |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with BRS3.
Interacts (via N-terminus) with SIN3B.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000066224 |
Miscellaneous databases
RNActi | Q99KU6, protein |
Family & Domainsi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S363, Eukaryota |
GeneTreei | ENSGT00390000014270 |
HOGENOMi | CLU_796829_0_0_1 |
InParanoidi | Q99KU6 |
OMAi | TTSEPCI |
OrthoDBi | 1010604at2759 |
PhylomeDBi | Q99KU6 |
TreeFami | TF335525 |
Family and domain databases
InterProi | View protein in InterPro IPR038757, BRAP |
PANTHERi | PTHR35259, PTHR35259, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All
Q99KU6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLAANEISI YDKLSETVDL VRQTGHQCGM SEKAIEKFIR QLLEKNEPQR
60 70 80 90 100
GPPQYPLLIA VYKVLLTLGL ILFTAYFVIQ PFSSLAPEPV LSGANSWRSL
110 120 130 140 150
VHHIRLVSLP ITKKYMPENK GVPLQGSQED KPFPDFDPWS SYNCEQNESE
160 170 180 190 200
PIPANCTGCA QILPLKVTLP EDTPKNFERL RPLVIKTGQP LSSAEIQSFS
210 220 230 240 250
CQYPEVTEGF TEGFFTKWWR CFPERWFPFP YPWRRPLNRS QILRELFPVF
260 270 280 290 300
TQLPFPKDSS LNKCFLIQPE PVVGSKMHKV HDLFTLGSGE AMLQLIPPFQ
310 320 330 340
CRTHCQSVAM PIESGDIGYA DAAHWKVYIV ARGVQPLVIC DGTTLSDL
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q4EG92 | A0A3Q4EG92_MOUSE | cDNA sequence BC004004 | BC004004 | 110 | Annotation score: | ||
A0A3Q4EGP5 | A0A3Q4EGP5_MOUSE | cDNA sequence BC004004 | BC004004 | 96 | Annotation score: | ||
A0A3Q4EH62 | A0A3Q4EH62_MOUSE | cDNA sequence BC004004 | BC004004 | 232 | Annotation score: | ||
A0A3Q4EI31 | A0A3Q4EI31_MOUSE | cDNA sequence BC004004 | BC004004 | 387 | Annotation score: | ||
A0A3Q4L2T6 | A0A3Q4L2T6_MOUSE | cDNA sequence BC004004 | BC004004 | 165 | Annotation score: | ||
A0A3Q4EGZ6 | A0A3Q4EGZ6_MOUSE | cDNA sequence BC004004 | BC004004 | 137 | Annotation score: | ||
A0A3Q4L2W7 | A0A3Q4L2W7_MOUSE | cDNA sequence BC004004 | BC004004 | 220 | Annotation score: | ||
A0A3Q4L2X7 | A0A3Q4L2X7_MOUSE | cDNA sequence BC004004 | BC004004 | 288 | Annotation score: | ||
A0A3Q4EC87 | A0A3Q4EC87_MOUSE | cDNA sequence BC004004 | BC004004 | 95 | Annotation score: | ||
A0A3Q4EGQ4 | A0A3Q4EGQ4_MOUSE | cDNA sequence BC004004 | BC004004 | 99 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence AAP45201 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 190 | P → S in AAH58575 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 198 | S → G in AAP45198 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 347 | D → E in AAP45198 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY301264 Genomic DNA Translation: AAP45198.1 AY301264 Genomic DNA Translation: AAP45201.1 Sequence problems. BC004004 mRNA Translation: AAH04004.1 BC058575 mRNA Translation: AAH58575.1 AK030596 mRNA Translation: BAC27038.1 |
CCDSi | CCDS28594.1 |
RefSeqi | NP_085038.3, NM_030561.3 XP_006525237.1, XM_006525174.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY301264 Genomic DNA Translation: AAP45198.1 AY301264 Genomic DNA Translation: AAP45201.1 Sequence problems. BC004004 mRNA Translation: AAH04004.1 BC058575 mRNA Translation: AAH58575.1 AK030596 mRNA Translation: BAC27038.1 |
CCDSi | CCDS28594.1 |
RefSeqi | NP_085038.3, NM_030561.3 XP_006525237.1, XM_006525174.3 |
3D structure databases
SMRi | Q99KU6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000066224 |
PTM databases
iPTMneti | Q99KU6 |
PhosphoSitePlusi | Q99KU6 |
Proteomic databases
EPDi | Q99KU6 |
PaxDbi | Q99KU6 |
PRIDEi | Q99KU6 |
Protocols and materials databases
Antibodypediai | 2729, 32 antibodies |
Genome annotation databases
Organism-specific databases
MGIi | MGI:2136782, BC004004 |
Phylogenomic databases
eggNOGi | ENOG502S363, Eukaryota |
GeneTreei | ENSGT00390000014270 |
HOGENOMi | CLU_796829_0_0_1 |
InParanoidi | Q99KU6 |
OMAi | TTSEPCI |
OrthoDBi | 1010604at2759 |
PhylomeDBi | Q99KU6 |
TreeFami | TF335525 |
Miscellaneous databases
BioGRID-ORCSi | 80748, 1 hit in 17 CRISPR screens |
PROi | PR:Q99KU6 |
RNActi | Q99KU6, protein |
Gene expression databases
Bgeei | ENSMUSG00000052712, Expressed in pituitary gland and 304 other tissues |
ExpressionAtlasi | Q99KU6, baseline and differential |
Genevisiblei | Q99KU6, MM |
Family and domain databases
InterProi | View protein in InterPro IPR038757, BRAP |
PANTHERi | PTHR35259, PTHR35259, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CF089_MOUSE | |
Accessioni | Q99KU6Primary (citable) accession number: Q99KU6 Secondary accession number(s): Q6PDQ4 Q8BST4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | May 30, 2006 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot