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Protein

Bombesin receptor-activated protein C6orf89 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Bombesin receptor-activated protein C6orf89 homolog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2136782 BC004004

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 58CytoplasmicCuratedAdd BLAST58
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 348ExtracellularCuratedAdd BLAST269

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002376221 – 348Bombesin receptor-activated protein C6orf89 homologAdd BLAST348

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99KU6
PRIDEiQ99KU6

PTM databases

iPTMnetiQ99KU6
PhosphoSitePlusiQ99KU6

Expressioni

Gene expression databases

BgeeiENSMUSG00000052712 Expressed in 287 organ(s), highest expression level in pituitary gland
CleanExiMM_BC004004
GenevisibleiQ99KU6 MM

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with BRS3. Interacts (via N-terminus) with SIN3B.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ99KU6
SMRiQ99KU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE6D Eukaryota
ENOG410YJCN LUCA
GeneTreeiENSGT00390000014270
HOGENOMiHOG000070100
HOVERGENiHBG055530
InParanoidiQ99KU6
OMAiRMHDLFT
OrthoDBiEOG091G097D
PhylomeDBiQ99KU6
TreeFamiTF335525

Family and domain databases

InterProiView protein in InterPro
IPR038757 BRAP
PANTHERiPTHR35259 PTHR35259, 1 hit

Sequencei

Sequence statusi: Complete.

Q99KU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLAANEISI YDKLSETVDL VRQTGHQCGM SEKAIEKFIR QLLEKNEPQR
60 70 80 90 100
GPPQYPLLIA VYKVLLTLGL ILFTAYFVIQ PFSSLAPEPV LSGANSWRSL
110 120 130 140 150
VHHIRLVSLP ITKKYMPENK GVPLQGSQED KPFPDFDPWS SYNCEQNESE
160 170 180 190 200
PIPANCTGCA QILPLKVTLP EDTPKNFERL RPLVIKTGQP LSSAEIQSFS
210 220 230 240 250
CQYPEVTEGF TEGFFTKWWR CFPERWFPFP YPWRRPLNRS QILRELFPVF
260 270 280 290 300
TQLPFPKDSS LNKCFLIQPE PVVGSKMHKV HDLFTLGSGE AMLQLIPPFQ
310 320 330 340
CRTHCQSVAM PIESGDIGYA DAAHWKVYIV ARGVQPLVIC DGTTLSDL
Length:348
Mass (Da):39,486
Last modified:May 30, 2006 - v2
Checksum:i4DC5F56EACB84759
GO

Sequence cautioni

The sequence AAP45201 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190P → S in AAH58575 (PubMed:15489334).Curated1
Sequence conflicti198S → G in AAP45198 (PubMed:15489334).Curated1
Sequence conflicti347D → E in AAP45198 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301264 Genomic DNA Translation: AAP45198.1
AY301264 Genomic DNA Translation: AAP45201.1 Sequence problems.
BC004004 mRNA Translation: AAH04004.1
BC058575 mRNA Translation: AAH58575.1
AK030596 mRNA Translation: BAC27038.1
CCDSiCCDS28594.1
UniGeneiMm.290116

Genome annotation databases

EnsembliENSMUST00000064709; ENSMUSP00000066224; ENSMUSG00000052712
ENSMUST00000120346; ENSMUSP00000113315; ENSMUSG00000052712
ENSMUST00000149405; ENSMUSP00000117309; ENSMUSG00000052712
GeneIDi80748
KEGGimmu:80748
UCSCiuc008bsn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301264 Genomic DNA Translation: AAP45198.1
AY301264 Genomic DNA Translation: AAP45201.1 Sequence problems.
BC004004 mRNA Translation: AAH04004.1
BC058575 mRNA Translation: AAH58575.1
AK030596 mRNA Translation: BAC27038.1
CCDSiCCDS28594.1
UniGeneiMm.290116

3D structure databases

ProteinModelPortaliQ99KU6
SMRiQ99KU6
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ99KU6
PhosphoSitePlusiQ99KU6

Proteomic databases

PaxDbiQ99KU6
PRIDEiQ99KU6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064709; ENSMUSP00000066224; ENSMUSG00000052712
ENSMUST00000120346; ENSMUSP00000113315; ENSMUSG00000052712
ENSMUST00000149405; ENSMUSP00000117309; ENSMUSG00000052712
GeneIDi80748
KEGGimmu:80748
UCSCiuc008bsn.2 mouse

Organism-specific databases

MGIiMGI:2136782 BC004004

Phylogenomic databases

eggNOGiENOG410IE6D Eukaryota
ENOG410YJCN LUCA
GeneTreeiENSGT00390000014270
HOGENOMiHOG000070100
HOVERGENiHBG055530
InParanoidiQ99KU6
OMAiRMHDLFT
OrthoDBiEOG091G097D
PhylomeDBiQ99KU6
TreeFamiTF335525

Miscellaneous databases

PROiPR:Q99KU6

Gene expression databases

BgeeiENSMUSG00000052712 Expressed in 287 organ(s), highest expression level in pituitary gland
CleanExiMM_BC004004
GenevisibleiQ99KU6 MM

Family and domain databases

InterProiView protein in InterPro
IPR038757 BRAP
PANTHERiPTHR35259 PTHR35259, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCF089_MOUSE
AccessioniPrimary (citable) accession number: Q99KU6
Secondary accession number(s): Q6PDQ4
, Q7TSE2, Q7TSE4, Q8BST4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: November 7, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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