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Protein

Endoribonuclease LACTB2

Gene

Lactb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi77Zinc 1; via tele nitrogenBy similarity1
Metal bindingi79Zinc 1; via pros nitrogenBy similarity1
Metal bindingi81Zinc 2By similarity1
Metal bindingi82Zinc 2; via tele nitrogenBy similarity1
Metal bindingi118Zinc 1By similarity1
Metal bindingi118Zinc 2By similarity1
Metal bindingi145Zinc 1; via tele nitrogenBy similarity1
Metal bindingi164Zinc 1By similarity1
Metal bindingi164Zinc 2By similarity1
Metal bindingi199Zinc 2; via tele nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Endoribonuclease LACTB2By similarity
Alternative name(s):
Beta-lactamase-like protein 2 (EC:3.1.27.-By similarity)
Gene namesi
Name:Lactb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2442551 Lactb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157441 – 288Endoribonuclease LACTB2Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102N6-acetyllysineCombined sources1
Modified residuei235PhosphoserineCombined sources1
Modified residuei273N6-succinyllysineCombined sources1
Modified residuei282N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99KR3
MaxQBiQ99KR3
PaxDbiQ99KR3
PeptideAtlasiQ99KR3
PRIDEiQ99KR3

PTM databases

iPTMnetiQ99KR3
PhosphoSitePlusiQ99KR3
SwissPalmiQ99KR3

Expressioni

Gene expression databases

BgeeiENSMUSG00000025937 Expressed in 276 organ(s), highest expression level in proximal tubule
CleanExiMM_LACTB2
GenevisibleiQ99KR3 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ99KR3, 5 interactors
MINTiQ99KR3
STRINGi10090.ENSMUSP00000027071

Structurei

3D structure databases

ProteinModelPortaliQ99KR3
SMRiQ99KR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0813 Eukaryota
COG0491 LUCA
GeneTreeiENSGT00390000001710
HOGENOMiHOG000246879
HOVERGENiHBG099837
InParanoidiQ99KR3
KOiK16639
OMAiHTTDHVV
OrthoDBiEOG091G0M3C
PhylomeDBiQ99KR3
TreeFamiTF314297

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00753 Lactamase_B, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit

Sequencei

Sequence statusi: Complete.

Q99KR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAALQRIEQ LSSRVVRVLG CNPGPMTLQG TNTYLVGTGS RRILIDTGEP
60 70 80 90 100
SVPEYISCLK QALVEFDTAI QEILVTHWHS DHSGGIVDIC KNINNDTTYC
110 120 130 140 150
IKKLRRNPQR EEIIGNGEQQ FIYIENGDVV KTEGATLRVL YTPGHTDDHM
160 170 180 190 200
ALLLEEENAI FSGDCILGEG TTIFEDLYDY MNSLNNLLKI KANIIYPGHG
210 220 230 240 250
PVIHNAEAKI LEYISHRNNR EEQIISLFRD NFEKSFTVTE LRTMIYKDVP
260 270 280
ENLHKMAEHN LLLHLRKLEK DGKIFYTTTP VKKWKAVL
Length:288
Mass (Da):32,754
Last modified:June 1, 2001 - v1
Checksum:iC2155F3C01F74B94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088932 mRNA Translation: BAC40659.1
AK143912 mRNA Translation: BAE25598.1
BC004045 mRNA Translation: AAH04045.1
CCDSiCCDS14823.1
RefSeqiNP_663356.1, NM_145381.2
UniGeneiMm.89572

Genome annotation databases

EnsembliENSMUST00000027071; ENSMUSP00000027071; ENSMUSG00000025937
GeneIDi212442
KEGGimmu:212442
UCSCiuc007aiu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088932 mRNA Translation: BAC40659.1
AK143912 mRNA Translation: BAE25598.1
BC004045 mRNA Translation: AAH04045.1
CCDSiCCDS14823.1
RefSeqiNP_663356.1, NM_145381.2
UniGeneiMm.89572

3D structure databases

ProteinModelPortaliQ99KR3
SMRiQ99KR3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99KR3, 5 interactors
MINTiQ99KR3
STRINGi10090.ENSMUSP00000027071

PTM databases

iPTMnetiQ99KR3
PhosphoSitePlusiQ99KR3
SwissPalmiQ99KR3

Proteomic databases

EPDiQ99KR3
MaxQBiQ99KR3
PaxDbiQ99KR3
PeptideAtlasiQ99KR3
PRIDEiQ99KR3

Protocols and materials databases

DNASUi212442
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027071; ENSMUSP00000027071; ENSMUSG00000025937
GeneIDi212442
KEGGimmu:212442
UCSCiuc007aiu.2 mouse

Organism-specific databases

CTDi51110
MGIiMGI:2442551 Lactb2

Phylogenomic databases

eggNOGiKOG0813 Eukaryota
COG0491 LUCA
GeneTreeiENSGT00390000001710
HOGENOMiHOG000246879
HOVERGENiHBG099837
InParanoidiQ99KR3
KOiK16639
OMAiHTTDHVV
OrthoDBiEOG091G0M3C
PhylomeDBiQ99KR3
TreeFamiTF314297

Miscellaneous databases

PROiPR:Q99KR3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025937 Expressed in 276 organ(s), highest expression level in proximal tubule
CleanExiMM_LACTB2
GenevisibleiQ99KR3 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00753 Lactamase_B, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLACB2_MOUSE
AccessioniPrimary (citable) accession number: Q99KR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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