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Protein

Ras-related protein Rab-28

Gene

Rab28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27GTPBy similarity9
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi129 – 132GTPBy similarity4
Nucleotide bindingi159 – 161GTPBy similarity3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • Rab protein signal transduction Source: GO_Central
  • toxin transport Source: MGI

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-28
Gene namesi
Name:Rab28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1917285 Rab28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001212282 – 218Ras-related protein Rab-28Add BLAST217
PropeptideiPRO_0000396722219 – 221Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei218Cysteine methyl esterBy similarity1
Lipidationi218S-farnesyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ99KL7
MaxQBiQ99KL7
PaxDbiQ99KL7
PRIDEiQ99KL7

PTM databases

iPTMnetiQ99KL7
PhosphoSitePlusiQ99KL7

Expressioni

Gene expression databases

BgeeiENSMUSG00000029128 Expressed in 292 organ(s), highest expression level in retina
CleanExiMM_RAB28
ExpressionAtlasiQ99KL7 baseline and differential
GenevisibleiQ99KL7 MM

Interactioni

Protein-protein interaction databases

IntActiQ99KL7, 3 interactors
STRINGi10090.ENSMUSP00000031011

Structurei

3D structure databases

ProteinModelPortaliQ99KL7
SMRiQ99KL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 49Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0078 Eukaryota
ENOG410XPUI LUCA
GeneTreeiENSGT00800000124173
HOGENOMiHOG000233968
HOVERGENiHBG101090
InParanoidiQ99KL7
KOiK07915
OrthoDBiEOG091G11JJ
PhylomeDBiQ99KL7
TreeFamiTF313852

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99KL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSEEESQD RQLKIVVLGD GTSGKTSLAT CFAQETFGKQ YKQTIGLDFF
60 70 80 90 100
LRRITLPGNL NVTLQVWDIG GQTIGGKMLD KYIYGAQGIL LVYDITNYQS
110 120 130 140 150
FENLEDWYSV VKTVSEESET QPLVALVGNK IDLEHMRTVK ADKHLRFCQE
160 170 180 190 200
NGFSSHFVSA KTGDSVFLCF QKVAAEILGI KLNKAEIEQS QRVVKADIVN
210 220
YNQEPLSRTV NPPRSSMCAV Q
Length:221
Mass (Da):24,728
Last modified:June 1, 2001 - v1
Checksum:i5520BD9CC0F78FB9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CZQ8Q9CZQ8_MOUSE
RAB28, member RAS oncogene family, ...
Rab28 mCG_22723
193Annotation score:
A0A0J9YV85A0A0J9YV85_MOUSE
Ras-related protein Rab-28
Rab28
220Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC004580 mRNA Translation: AAH04580.1
CCDSiCCDS19258.1
RefSeqiNP_081571.1, NM_027295.3
UniGeneiMm.41555

Genome annotation databases

EnsembliENSMUST00000031011; ENSMUSP00000031011; ENSMUSG00000029128
GeneIDi100972
KEGGimmu:100972
UCSCiuc008xha.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC004580 mRNA Translation: AAH04580.1
CCDSiCCDS19258.1
RefSeqiNP_081571.1, NM_027295.3
UniGeneiMm.41555

3D structure databases

ProteinModelPortaliQ99KL7
SMRiQ99KL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99KL7, 3 interactors
STRINGi10090.ENSMUSP00000031011

PTM databases

iPTMnetiQ99KL7
PhosphoSitePlusiQ99KL7

Proteomic databases

EPDiQ99KL7
MaxQBiQ99KL7
PaxDbiQ99KL7
PRIDEiQ99KL7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031011; ENSMUSP00000031011; ENSMUSG00000029128
GeneIDi100972
KEGGimmu:100972
UCSCiuc008xha.1 mouse

Organism-specific databases

CTDi9364
MGIiMGI:1917285 Rab28

Phylogenomic databases

eggNOGiKOG0078 Eukaryota
ENOG410XPUI LUCA
GeneTreeiENSGT00800000124173
HOGENOMiHOG000233968
HOVERGENiHBG101090
InParanoidiQ99KL7
KOiK07915
OrthoDBiEOG091G11JJ
PhylomeDBiQ99KL7
TreeFamiTF313852

Miscellaneous databases

ChiTaRSiRab28 mouse
PROiPR:Q99KL7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029128 Expressed in 292 organ(s), highest expression level in retina
CleanExiMM_RAB28
ExpressionAtlasiQ99KL7 baseline and differential
GenevisibleiQ99KL7 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB28_MOUSE
AccessioniPrimary (citable) accession number: Q99KL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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