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Protein

Transcription factor 19-like protein

Gene

Tcf19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

This sequence is very similar to other orthologs but it lacks the PHD-type zinc finger domain which may be important for the trans-activation function.

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: MGI
  • regulation of gene expression Source: MGI
  • type B pancreatic cell proliferation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 19-like protein
Short name:
TCF-19
Alternative name(s):
SC1 protein homolog
Gene namesi
Name:Tcf19
Synonyms:Sc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103180 Tcf19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000593301 – 263Transcription factor 19-like proteinAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99KJ5
PRIDEiQ99KJ5

PTM databases

PhosphoSitePlusiQ99KJ5

Expressioni

Gene expression databases

CleanExiMM_TCF19

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125167

Structurei

3D structure databases

ProteinModelPortaliQ99KJ5
SMRiQ99KJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 88FHAPROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG410IXZZ Eukaryota
ENOG4111J5W LUCA
HOGENOMiHOG000261618
HOVERGENiHBG054343
InParanoidiQ99KJ5

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99KJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPCFQLLRI GGGRGGDLYT FHPPSKSGCT YGLGCRADLC DVALRPQQEP
60 70 80 90 100
GLISGVHAEL HAELQGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD
110 120 130 140 150
LLTFGPQGQA GTSSSSEFYF MFQQVRVKPQ DFAAITVPRS KGEAGGGFQP
160 170 180 190 200
MLPPQGAPQR PLSTLSSAPK ATLILNSIGS LSKLQAQPLT FSRGGGRPQG
210 220 230 240 250
LAIPSQHGEA QVSPAPPTRN RRKSAHKVLA ELDDEVSPGP LSVLTEPRKR
260
LRVEKAALIA SGE
Length:263
Mass (Da):28,068
Last modified:June 1, 2001 - v1
Checksum:iF210FECDD614E62A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XA31G3XA31_MOUSE
Transcription factor 19, isoform CR...
Tcf19 mCG_19909
263Annotation score:
E0CY69E0CY69_MOUSE
Transcription factor 19-like protei...
Tcf19
201Annotation score:
E0CZ64E0CZ64_MOUSE
Transcription factor 19-like protei...
Tcf19
147Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32G → R in BAC36789 (PubMed:16141072).Curated1
Sequence conflicti130Q → E in BAB23229 (PubMed:16141072).Curated1
Sequence conflicti252R → W in BAC36789 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077414 mRNA Translation: BAC36789.1
AK088479 mRNA Translation: BAC40380.1
AK004231 mRNA Translation: BAB23229.1
BC004617 mRNA Translation: AAH04617.1
CCDSiCCDS50089.1
PIRiB61188
RefSeqiNP_001157235.1, NM_001163763.1
NP_001157236.1, NM_001163764.1
NP_079950.2, NM_025674.2
UniGeneiMm.11434
Mm.475434

Genome annotation databases

GeneIDi106795
KEGGimmu:106795

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077414 mRNA Translation: BAC36789.1
AK088479 mRNA Translation: BAC40380.1
AK004231 mRNA Translation: BAB23229.1
BC004617 mRNA Translation: AAH04617.1
CCDSiCCDS50089.1
PIRiB61188
RefSeqiNP_001157235.1, NM_001163763.1
NP_001157236.1, NM_001163764.1
NP_079950.2, NM_025674.2
UniGeneiMm.11434
Mm.475434

3D structure databases

ProteinModelPortaliQ99KJ5
SMRiQ99KJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125167

PTM databases

PhosphoSitePlusiQ99KJ5

Proteomic databases

PaxDbiQ99KJ5
PRIDEiQ99KJ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi106795
KEGGimmu:106795

Organism-specific databases

CTDi6941
MGIiMGI:103180 Tcf19

Phylogenomic databases

eggNOGiENOG410IXZZ Eukaryota
ENOG4111J5W LUCA
HOGENOMiHOG000261618
HOVERGENiHBG054343
InParanoidiQ99KJ5

Miscellaneous databases

ChiTaRSiAlcam mouse
PROiPR:Q99KJ5
SOURCEiSearch...

Gene expression databases

CleanExiMM_TCF19

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCF19_MOUSE
AccessioniPrimary (citable) accession number: Q99KJ5
Secondary accession number(s): Q8BPA3, Q9CT93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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