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Entry version 129 (02 Jun 2021)
Sequence version 1 (01 Jun 2001)
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Protein

UBX domain-containing protein 2A

Gene

Ubxn2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UBX domain-containing protein 2A
Alternative name(s):
UBX domain-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ubxn2a
Synonyms:Ubxd4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442310, Ubxn2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002110321 – 258UBX domain-containing protein 2AAdd BLAST258

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99KJ0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99KJ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99KJ0

PeptideAtlas

More...
PeptideAtlasi
Q99KJ0

PRoteomics IDEntifications database

More...
PRIDEi
Q99KJ0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
298425

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99KJ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99KJ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020634, Expressed in quadriceps femoris and 277 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99KJ0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99KJ0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229908, 6 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000020962

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99KJ0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99KJ0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini61 – 125SEPPROSITE-ProRule annotationAdd BLAST65
Domaini170 – 247UBXPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2086, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055567

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029402_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99KJ0

Identification of Orthologs from Complete Genome Data

More...
OMAi
VSHRISH

Database of Orthologous Groups

More...
OrthoDBi
1175850at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99KJ0

TreeFam database of animal gene trees

More...
TreeFami
TF312973

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036241, NSFL1C_SEP_dom_sf
IPR012989, SEP_domain
IPR029071, Ubiquitin-like_domsf
IPR001012, UBX_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08059, SEP, 1 hit
PF00789, UBX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00553, SEP, 1 hit
SM00166, UBX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF102848, SSF102848, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51399, SEP, 1 hit
PS50033, UBX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99KJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEVDNLDSI KEEWACETGP PDSQPLNDNQ QKDCEYFVDS LFEEAGKAGA
60 70 80 90 100
KCLSPTEQKK QVDVNIKLWK NGFTVNDDFR SYSDGASQQF LNSIKKGELP
110 120 130 140 150
SELWGIFDKE EVDVKVEDKK NEVCMSTKPV FQPFSGQGHR LGSATPRIVS
160 170 180 190 200
KAKSVEVDNK STLSAVSLNN LEPITRIQIW LANGERTVQR FNVSHRVSHI
210 220 230 240 250
KDFIEKYQGS QRSPPFALAT ALPFLRFLDE TLTLEEADLK NAVIIQRLQK

TAEPFRKL
Length:258
Mass (Da):29,197
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2901BAE396F5CE2A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGU9D6RGU9_MOUSE
UBX domain-containing protein 2A
Ubxn2a
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK031821 mRNA Translation: BAC27566.1
AK041556 mRNA Translation: BAC30984.1
BC004632 mRNA Translation: AAH04632.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25795.1

NCBI Reference Sequences

More...
RefSeqi
NP_663416.1, NM_145441.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000020962; ENSMUSP00000020962; ENSMUSG00000020634
ENSMUST00000142867; ENSMUSP00000118834; ENSMUSG00000020634

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
217379

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:217379

UCSC genome browser

More...
UCSCi
uc007myr.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031821 mRNA Translation: BAC27566.1
AK041556 mRNA Translation: BAC30984.1
BC004632 mRNA Translation: AAH04632.1
CCDSiCCDS25795.1
RefSeqiNP_663416.1, NM_145441.3

3D structure databases

SMRiQ99KJ0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229908, 6 interactors
STRINGi10090.ENSMUSP00000020962

PTM databases

iPTMnetiQ99KJ0
PhosphoSitePlusiQ99KJ0

Proteomic databases

EPDiQ99KJ0
MaxQBiQ99KJ0
PaxDbiQ99KJ0
PeptideAtlasiQ99KJ0
PRIDEiQ99KJ0
ProteomicsDBi298425

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
58573, 92 antibodies

The DNASU plasmid repository

More...
DNASUi
217379

Genome annotation databases

EnsembliENSMUST00000020962; ENSMUSP00000020962; ENSMUSG00000020634
ENSMUST00000142867; ENSMUSP00000118834; ENSMUSG00000020634
GeneIDi217379
KEGGimmu:217379
UCSCiuc007myr.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
165324
MGIiMGI:2442310, Ubxn2a

Phylogenomic databases

eggNOGiKOG2086, Eukaryota
GeneTreeiENSGT00520000055567
HOGENOMiCLU_029402_3_1_1
InParanoidiQ99KJ0
OMAiVSHRISH
OrthoDBi1175850at2759
PhylomeDBiQ99KJ0
TreeFamiTF312973

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
217379, 9 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ubxn2a, mouse

Protein Ontology

More...
PROi
PR:Q99KJ0
RNActiQ99KJ0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020634, Expressed in quadriceps femoris and 277 other tissues
ExpressionAtlasiQ99KJ0, baseline and differential
GenevisibleiQ99KJ0, MM

Family and domain databases

Gene3Di3.30.420.210, 1 hit
InterProiView protein in InterPro
IPR036241, NSFL1C_SEP_dom_sf
IPR012989, SEP_domain
IPR029071, Ubiquitin-like_domsf
IPR001012, UBX_dom
PfamiView protein in Pfam
PF08059, SEP, 1 hit
PF00789, UBX, 1 hit
SMARTiView protein in SMART
SM00553, SEP, 1 hit
SM00166, UBX, 1 hit
SUPFAMiSSF102848, SSF102848, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51399, SEP, 1 hit
PS50033, UBX, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBX2A_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99KJ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2001
Last modified: June 2, 2021
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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