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Protein

Caspase recruitment domain-containing protein 14

Gene

Card14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.By similarity

Caution

Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 14
Alternative name(s):
Bcl10-interacting MAGUK protein 2
Short name:
Bimp2
Gene namesi
Name:Card14
Synonyms:Bimp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2386258 Card14

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440891 – 999Caspase recruitment domain-containing protein 14Add BLAST999

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei541PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99KF0
PaxDbiQ99KF0
PRIDEiQ99KF0

PTM databases

iPTMnetiQ99KF0
PhosphoSitePlusiQ99KF0

Expressioni

Gene expression databases

BgeeiENSMUSG00000013483 Expressed in 63 organ(s), highest expression level in epithelium of tongue
CleanExiMM_CARD14
GenevisibleiQ99KF0 MM

Interactioni

Subunit structurei

Interacts (via CARD domain) with BCL10 (via CARD domain). Forms a complex with MALT1 and BCL10; resulting in the formation of a CBM (CARD14-BLC10-MALT1) complex. Interacts with TRAF2, TRAF3 and TRAF6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053665

Structurei

3D structure databases

ProteinModelPortaliQ99KF0
SMRiQ99KF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 107CARDPROSITE-ProRule annotationAdd BLAST93
Domaini572 – 655PDZPROSITE-ProRule annotationAdd BLAST84
Domaini803 – 986Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni409 – 565Maintains the protein in an inactive stateBy similarityAdd BLAST157

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili125 – 411Sequence analysisAdd BLAST287

Domaini

A linker region between the coiled-coil and PDZ region holds the protein in an inactive state.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00530000063108
HOGENOMiHOG000049174
HOVERGENiHBG106927
InParanoidiQ99KF0
KOiK20913
OMAiTQIVMVD
OrthoDBiEOG091G0T58
PhylomeDBiQ99KF0
TreeFamiTF315606

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00619 CARD, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q99KF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAELCRMDST LTALDEEMLW DMLESHRCRI VQSICPSRLT PYLRQAKVLG
60 70 80 90 100
QLDEEEILHS SRFTNSAMRV GHLLDLLKAR GKNGAIAFLE SLKFHNPDVY
110 120 130 140 150
TLVTGLQSDI DFSTFSGLME TSKLTECLAG AISSLQEELA QEKAQKEVLL
160 170 180 190 200
RRCQQLKERL GLAEAHAEGL RQLEVDHSRM KREVSTHFHE VLKLKDEMLN
210 220 230 240 250
LSLHYSNALR EKELAATRCH SLQEELYLVK QELQRASLVS SCERESRERS
260 270 280 290 300
LKMASNLEPQ GEELNRLKEE NEKLRSMTFS LVEKDILEQS LDEARESKQE
310 320 330 340 350
LVDRIHSLRE RAVAAERQQK QYWEEKEQTL LQFRKTQVDC ELYKEKMTML
360 370 380 390 400
QGQVAELQKE RDQAYTARDR AQMEISQRLV EKDALRRRVF ELTEQVCELR
410 420 430 440 450
TQLRRLQAEA PGGPKQEAGA RELCLRGKQR LVRMHAVCPP DDSDCSLLSS
460 470 480 490 500
TESRLWWDLN STSSREQMDS FRSSSPMPPS QQSLYKRVAE DFLEDPESLS
510 520 530 540 550
FPEVLEMRLQ GATVDDTDTD LEFEMIDGAD LSQTEDSLQG SSRSLNVSES
560 570 580 590 600
SVPVRRRPAR KILSQVTVLA FQGDALLEQI GVIGGNLTGI FIHRVTPGSA
610 620 630 640 650
ADEMALRPGT QIMMVDYKPT KPSLRATLEN TTLEQAVGLL RRVNGSCYLS
660 670 680 690 700
VKINTEGYKN LIQDLDAKVV TSGDSFYIRV NLAMQRGGDG ELQTHCNDIL
710 720 730 740 750
HVTDTMFQGR SCWHAHHVNP YTMKDMEPGT IPNYSQAQQQ LLALIQDMTQ
760 770 780 790 800
RCTVPRKPPG GPQKLVRIVS VDKAAVSPLT SSFDQSQWDS GKEEGGPSVC
810 820 830 840 850
FWSESCFTLA PYTLVHPHRP ARPRPVLFVP RLVGRILGKK LCLLQGFKQC
860 870 880 890 900
SAEYLSQEEY ATWSQRGDII QEGESIGDHH WITRHAVESL MNMSTHALLD
910 920 930 940 950
VRLDSVRVLH RMDMFPIIIH VSVNEKTAKK LRKGLHRLGS SEEQFLEVAR
960 970 980 990
QEEGELDRVP CLYSSLAPDS WSDLDSLLSC VRLAIADEQK KVVWTESPC
Length:999
Mass (Da):113,497
Last modified:January 31, 2002 - v2
Checksum:iD18350DA12430255
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti736 – 743QAQQQLLA → HLLEDHRS in AAH04692 (PubMed:15489334).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363457 mRNA Translation: AAK60137.1
BC004692 mRNA Translation: AAH04692.1
BC029102 mRNA Translation: AAH29102.1
CCDSiCCDS25715.1
RefSeqiNP_570956.1, NM_130886.3
XP_006532439.1, XM_006532376.1
UniGeneiMm.130832

Genome annotation databases

EnsembliENSMUST00000053245; ENSMUSP00000053665; ENSMUSG00000013483
ENSMUST00000106250; ENSMUSP00000101857; ENSMUSG00000013483
GeneIDi170720
KEGGimmu:170720
UCSCiuc007mqk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363457 mRNA Translation: AAK60137.1
BC004692 mRNA Translation: AAH04692.1
BC029102 mRNA Translation: AAH29102.1
CCDSiCCDS25715.1
RefSeqiNP_570956.1, NM_130886.3
XP_006532439.1, XM_006532376.1
UniGeneiMm.130832

3D structure databases

ProteinModelPortaliQ99KF0
SMRiQ99KF0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053665

PTM databases

iPTMnetiQ99KF0
PhosphoSitePlusiQ99KF0

Proteomic databases

MaxQBiQ99KF0
PaxDbiQ99KF0
PRIDEiQ99KF0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053245; ENSMUSP00000053665; ENSMUSG00000013483
ENSMUST00000106250; ENSMUSP00000101857; ENSMUSG00000013483
GeneIDi170720
KEGGimmu:170720
UCSCiuc007mqk.1 mouse

Organism-specific databases

CTDi79092
MGIiMGI:2386258 Card14

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00530000063108
HOGENOMiHOG000049174
HOVERGENiHBG106927
InParanoidiQ99KF0
KOiK20913
OMAiTQIVMVD
OrthoDBiEOG091G0T58
PhylomeDBiQ99KF0
TreeFamiTF315606

Miscellaneous databases

ChiTaRSiCard14 mouse
PROiPR:Q99KF0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000013483 Expressed in 63 organ(s), highest expression level in epithelium of tongue
CleanExiMM_CARD14
GenevisibleiQ99KF0 MM

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00619 CARD, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAR14_MOUSE
AccessioniPrimary (citable) accession number: Q99KF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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