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Protein

Zinc finger protein 64

Gene

Zfp64

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi495Zinc 1By similarity1
Metal bindingi498Zinc 1By similarity1
Metal bindingi511Zinc 1By similarity1
Metal bindingi515Zinc 1By similarity1
Metal bindingi523Zinc 2By similarity1
Metal bindingi526Zinc 2By similarity1
Metal bindingi539Zinc 2By similarity1
Metal bindingi544Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 322C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri328 – 350C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 463C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri465 – 487C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • positive regulation of interferon-beta production Source: CACAO
  • positive regulation of interleukin-6 production Source: CACAO
  • positive regulation of mRNA splicing, via spliceosome Source: MGI
  • positive regulation of tumor necrosis factor production Source: CACAO
  • regulation of gene expression Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 64
Short name:
Zfp-64
Gene namesi
Name:Zfp64
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107342 Zfp64

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473091 – 643Zinc finger protein 64Add BLAST643

Proteomic databases

PRIDEiQ99KE8

PTM databases

iPTMnetiQ99KE8
PhosphoSitePlusiQ99KE8

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Expressed from E10.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000027551 Expressed in 222 organ(s), highest expression level in placenta
CleanExiMM_ZFP64
ExpressionAtlasiQ99KE8 baseline and differential
GenevisibleiQ99KE8 MM

Structurei

3D structure databases

ProteinModelPortaliQ99KE8
SMRiQ99KE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 134Thr-richAdd BLAST78

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 322C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri328 – 350C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 463C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri465 – 487C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00890000139371
HOGENOMiHOG000230887
HOVERGENiHBG056373
InParanoidiQ99KE8
PhylomeDBiQ99KE8

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99KE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNASVEGDTF SGSMQIPGGT TVLVELAPDI HICGLCKQHF SNLDAFVAHK
60 70 80 90 100
QSGCQLTTTP VTAPSTVQFV AEETEPATQT TTTTISSETQ TITVSAPEFV
110 120 130 140 150
FEHGYQTYLP TESTDNQTAT VISLPTKSRT KKPTAPPAQK RLGCCYPGCQ
160 170 180 190 200
FKTAYGMKDM ERHLKIHTGD KPHKCEVCGK CFSRKDKLKT HMRCHTGVKP
210 220 230 240 250
YKCKTCDYAA ADSSSLNKHL RIHSDERPFK CQICPYASRN SSQLTVHLRS
260 270 280 290 300
HTASVLENDV QKPAGLPAEE SDAQQAPAVT LSLEAKERTA TLGERTFNCR
310 320 330 340 350
YPGCHFKTVH GMKDLDRHLR IHTGDKPHKC EFCDKCFSRK DNLTMHMRCH
360 370 380 390 400
TSVKPHKCHL CDYAAVDSSS LKKHLRIHSD ERPYKCQLCP YASRNSSQLT
410 420 430 440 450
VHLRSHTGDT PFQCWLCSAK FKISSDLKRH MIVHSGEKPF KCEFCDVRCT
460 470 480 490 500
MKANLKSHIR IKHTFKCLHC AFQGRDRADL LEHSRLHQAD HPEKCPECSY
510 520 530 540 550
SCSNPAALRV HSRVHCTDRP FKCDFCSFDT KRPSSLAKHI DKVHREGAKT
560 570 580 590 600
ENRAPPGKDG PGESGPHHVP NVSTQRAFGC DKCGASFVRD DSLRCHRKQH
610 620 630 640
SDWGENKNSN LVTFPSEGIA TGQLGPLVSV GQLESTLEPS HDL
Length:643
Mass (Da):71,765
Last modified:June 1, 2001 - v1
Checksum:iA04D3E5DD96EBD2D
GO
Isoform 2 (identifier: Q99KE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-272: SVLENDVQKPAGLPAEESD → WRCDCLGSTKPWVPSLVTT
     273-643: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):29,965
Checksum:i87F541E6A8D9BB76
GO
Isoform 3 (identifier: Q99KE8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-388: Missing.
     464-628: TFKCLHCAFQ...IATGQLGPLV → SGNNFKCPHC...PSKQPLRPSP
     629-643: Missing.

Note: No experimental confirmation available.
Show »
Length:473
Mass (Da):53,317
Checksum:i56C848B1CDCC7902
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AQR4A2AQR4_MOUSE
Zinc finger protein 64
Zfp64 mCG_20647
676Annotation score:
A2AQR3A2AQR3_MOUSE
Zinc finger protein 64
Zfp64
643Annotation score:
A2AQR2A2AQR2_MOUSE
Zinc finger protein 64
Zfp64
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23L → V in AAC53039 (PubMed:9034307).Curated1
Sequence conflicti410T → A in AAC53039 (PubMed:9034307).Curated1
Sequence conflicti432I → R in AAC53039 (PubMed:9034307).Curated1
Sequence conflicti446D → N in AAC53039 (PubMed:9034307).Curated1
Sequence conflicti453A → G in AAC53039 (PubMed:9034307).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007287234 – 388Missing in isoform 3. 1 PublicationAdd BLAST155
Alternative sequenceiVSP_007288254 – 272SVLEN…AEESD → WRCDCLGSTKPWVPSLVTT in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_007289273 – 643Missing in isoform 2. 1 PublicationAdd BLAST371
Alternative sequenceiVSP_007290464 – 628TFKCL…LGPLV → SGNNFKCPHCDFLGDSKSTL RKHSRLHQSEHPEKCPECSY SCSSKAALRVHERIHCTERP FKCSYCSFDTKQPSNLSKHM KKFHADMLKNEAPEKKESGR QSSRQVARLDAKKTFHCDIC DASFMREDSLRSHKRQHSEY HSKNSDVTVVQLHLEPSKQP LRPSP in isoform 3. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_007291629 – 643Missing in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49046 mRNA Translation: AAC53039.1
AK010444 mRNA No translation available.
BC004695 mRNA Translation: AAH04695.1
UniGeneiMm.2095
Mm.482454

Genome annotation databases

EnsembliENSMUST00000109161; ENSMUSP00000104789; ENSMUSG00000027551 [Q99KE8-2]
UCSCiuc008obl.1 mouse [Q99KE8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49046 mRNA Translation: AAC53039.1
AK010444 mRNA No translation available.
BC004695 mRNA Translation: AAH04695.1
UniGeneiMm.2095
Mm.482454

3D structure databases

ProteinModelPortaliQ99KE8
SMRiQ99KE8
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ99KE8
PhosphoSitePlusiQ99KE8

Proteomic databases

PRIDEiQ99KE8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109161; ENSMUSP00000104789; ENSMUSG00000027551 [Q99KE8-2]
UCSCiuc008obl.1 mouse [Q99KE8-2]

Organism-specific databases

MGIiMGI:107342 Zfp64

Phylogenomic databases

GeneTreeiENSGT00890000139371
HOGENOMiHOG000230887
HOVERGENiHBG056373
InParanoidiQ99KE8
PhylomeDBiQ99KE8

Miscellaneous databases

ChiTaRSiZfp90 mouse
PROiPR:Q99KE8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027551 Expressed in 222 organ(s), highest expression level in placenta
CleanExiMM_ZFP64
ExpressionAtlasiQ99KE8 baseline and differential
GenevisibleiQ99KE8 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP64_MOUSE
AccessioniPrimary (citable) accession number: Q99KE8
Secondary accession number(s): P97365, Q9CWR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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