UniProtKB - Q99KE8 (ZFP64_MOUSE)
Protein
Zinc finger protein 64
Gene
Zfp64
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 495 | Zinc 1By similarity | 1 | |
Metal bindingi | 498 | Zinc 1By similarity | 1 | |
Metal bindingi | 511 | Zinc 1By similarity | 1 | |
Metal bindingi | 515 | Zinc 1By similarity | 1 | |
Metal bindingi | 523 | Zinc 2By similarity | 1 | |
Metal bindingi | 526 | Zinc 2By similarity | 1 | |
Metal bindingi | 539 | Zinc 2By similarity | 1 | |
Metal bindingi | 544 | Zinc 2By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 173 – 195 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 201 – 223 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 229 – 251 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 297 – 322 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 328 – 350 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 356 – 378 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 463 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 465 – 487 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 493 – 515 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 578 – 600 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- positive regulation of interferon-beta production Source: CACAO
- positive regulation of interleukin-6 production Source: CACAO
- positive regulation of mRNA splicing, via spliceosome Source: MGI
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of tumor necrosis factor production Source: CACAO
- regulation of gene expression Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 64CuratedShort name: Zfp-64 |
Gene namesi | Name:Zfp64Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107342, Zfp64 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047309 | 1 – 643 | Zinc finger protein 64Add BLAST | 643 |
Proteomic databases
PRIDEi | Q99KE8 |
PTM databases
iPTMneti | Q99KE8 |
PhosphoSitePlusi | Q99KE8 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Developmental stagei
Expressed from 10.5 dpc.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000027551, Expressed in ectoplacental cone and 243 other tissues |
ExpressionAtlasi | Q99KE8, baseline and differential |
Genevisiblei | Q99KE8, MM |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 57 – 134 | Thr-richAdd BLAST | 78 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 173 – 195 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 201 – 223 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 229 – 251 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 297 – 322 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 328 – 350 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 356 – 378 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 463 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 465 – 487 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 493 – 515 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 578 – 600 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
GeneTreei | ENSGT00940000156405 |
HOGENOMi | CLU_1022925_0_0_1 |
InParanoidi | Q99KE8 |
PhylomeDBi | Q99KE8 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q99KE8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNASVEGDTF SGSMQIPGGT TVLVELAPDI HICGLCKQHF SNLDAFVAHK
60 70 80 90 100
QSGCQLTTTP VTAPSTVQFV AEETEPATQT TTTTISSETQ TITVSAPEFV
110 120 130 140 150
FEHGYQTYLP TESTDNQTAT VISLPTKSRT KKPTAPPAQK RLGCCYPGCQ
160 170 180 190 200
FKTAYGMKDM ERHLKIHTGD KPHKCEVCGK CFSRKDKLKT HMRCHTGVKP
210 220 230 240 250
YKCKTCDYAA ADSSSLNKHL RIHSDERPFK CQICPYASRN SSQLTVHLRS
260 270 280 290 300
HTASVLENDV QKPAGLPAEE SDAQQAPAVT LSLEAKERTA TLGERTFNCR
310 320 330 340 350
YPGCHFKTVH GMKDLDRHLR IHTGDKPHKC EFCDKCFSRK DNLTMHMRCH
360 370 380 390 400
TSVKPHKCHL CDYAAVDSSS LKKHLRIHSD ERPYKCQLCP YASRNSSQLT
410 420 430 440 450
VHLRSHTGDT PFQCWLCSAK FKISSDLKRH MIVHSGEKPF KCEFCDVRCT
460 470 480 490 500
MKANLKSHIR IKHTFKCLHC AFQGRDRADL LEHSRLHQAD HPEKCPECSY
510 520 530 540 550
SCSNPAALRV HSRVHCTDRP FKCDFCSFDT KRPSSLAKHI DKVHREGAKT
560 570 580 590 600
ENRAPPGKDG PGESGPHHVP NVSTQRAFGC DKCGASFVRD DSLRCHRKQH
610 620 630 640
SDWGENKNSN LVTFPSEGIA TGQLGPLVSV GQLESTLEPS HDL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2AQR3 | A2AQR3_MOUSE | Zinc finger protein 64 | Zfp64 | 643 | Annotation score: | ||
A2AQR2 | A2AQR2_MOUSE | Zinc finger protein 64 | Zfp64 | 84 | Annotation score: | ||
A2AQR4 | A2AQR4_MOUSE | Zinc finger protein 64 | Zfp64 | 676 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | L → V in AAC53039 (PubMed:9034307).Curated | 1 | |
Sequence conflicti | 410 | T → A in AAC53039 (PubMed:9034307).Curated | 1 | |
Sequence conflicti | 432 | I → R in AAC53039 (PubMed:9034307).Curated | 1 | |
Sequence conflicti | 446 | D → N in AAC53039 (PubMed:9034307).Curated | 1 | |
Sequence conflicti | 453 | A → G in AAC53039 (PubMed:9034307).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007287 | 234 – 388 | Missing in isoform 3. 1 PublicationAdd BLAST | 155 | |
Alternative sequenceiVSP_007288 | 254 – 272 | SVLEN…AEESD → WRCDCLGSTKPWVPSLVTT in isoform 2. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_007289 | 273 – 643 | Missing in isoform 2. 1 PublicationAdd BLAST | 371 | |
Alternative sequenceiVSP_007290 | 464 – 628 | TFKCL…LGPLV → SGNNFKCPHCDFLGDSKSTL RKHSRLHQSEHPEKCPECSY SCSSKAALRVHERIHCTERP FKCSYCSFDTKQPSNLSKHM KKFHADMLKNEAPEKKESGR QSSRQVARLDAKKTFHCDIC DASFMREDSLRSHKRQHSEY HSKNSDVTVVQLHLEPSKQP LRPSP in isoform 3. 1 PublicationAdd BLAST | 165 | |
Alternative sequenceiVSP_007291 | 629 – 643 | Missing in isoform 3. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U49046 mRNA Translation: AAC53039.1 AK010444 mRNA No translation available. BC004695 mRNA Translation: AAH04695.1 |
CCDSi | CCDS89588.1 [Q99KE8-1] |
Genome annotation databases
Ensembli | ENSMUST00000109161; ENSMUSP00000104789; ENSMUSG00000027551 [Q99KE8-2] |
UCSCi | uc008obl.1, mouse [Q99KE8-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U49046 mRNA Translation: AAC53039.1 AK010444 mRNA No translation available. BC004695 mRNA Translation: AAH04695.1 |
CCDSi | CCDS89588.1 [Q99KE8-1] |
3D structure databases
SMRi | Q99KE8 |
ModBasei | Search... |
PTM databases
iPTMneti | Q99KE8 |
PhosphoSitePlusi | Q99KE8 |
Proteomic databases
PRIDEi | Q99KE8 |
Protocols and materials databases
Antibodypediai | 13873, 199 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000109161; ENSMUSP00000104789; ENSMUSG00000027551 [Q99KE8-2] |
UCSCi | uc008obl.1, mouse [Q99KE8-2] |
Organism-specific databases
MGIi | MGI:107342, Zfp64 |
Phylogenomic databases
GeneTreei | ENSGT00940000156405 |
HOGENOMi | CLU_1022925_0_0_1 |
InParanoidi | Q99KE8 |
PhylomeDBi | Q99KE8 |
Miscellaneous databases
ChiTaRSi | Zfp64, mouse |
PROi | PR:Q99KE8 |
RNActi | Q99KE8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027551, Expressed in ectoplacental cone and 243 other tissues |
ExpressionAtlasi | Q99KE8, baseline and differential |
Genevisiblei | Q99KE8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFP64_MOUSE | |
Accessioni | Q99KE8Primary (citable) accession number: Q99KE8 Secondary accession number(s): P97365, Q9CWR3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 30, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families