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Protein

Protein unc-45 homolog A

Gene

Unc45a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen.By similarityCurated2 Publications

GO - Molecular functioni

  • Hsp90 protein binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionChaperone, Developmental protein
Biological processDifferentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-45 homolog A
Short name:
Unc-45A
Alternative name(s):
Stromal membrane-associated protein 1
Short name:
SMAP-1
Gene namesi
Name:Unc45a
Synonyms:Smap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142246 Unc45a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002498891 – 944Protein unc-45 homolog AAdd BLAST944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70N6-acetyllysineBy similarity1
Modified residuei483N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99KD5
MaxQBiQ99KD5
PaxDbiQ99KD5
PeptideAtlasiQ99KD5
PRIDEiQ99KD5

PTM databases

iPTMnetiQ99KD5
PhosphoSitePlusiQ99KD5

Expressioni

Tissue specificityi

Detected in spleen, bone marrow, lung and ovary, and at lower levels in testis, kidney, heart and brain (at protein level). Ubiquitous. Detected in uterus, large intestine, kidney, spleen, lung, brain, liver and ovary.2 Publications

Gene expression databases

BgeeiENSMUSG00000030533 Expressed in 300 organ(s), highest expression level in limb
CleanExiMM_SMAP1
MM_UNC45A
ExpressionAtlasiQ99KD5 baseline and differential
GenevisibleiQ99KD5 MM

Interactioni

Subunit structurei

Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221742, 1 interactor
STRINGi10090.ENSMUSP00000032748

Structurei

3D structure databases

ProteinModelPortaliQ99KD5
SMRiQ99KD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 54TPR 1Add BLAST34
Repeati58 – 91TPR 2Add BLAST34
Repeati92 – 125TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4151 Eukaryota
ENOG410XQNT LUCA
GeneTreeiENSGT00900000140844
HOGENOMiHOG000285994
HOVERGENiHBG057344
InParanoidiQ99KD5
KOiK21991
OMAiDQGLKKI
OrthoDBiEOG091G02FM
PhylomeDBiQ99KD5
TreeFamiTF314096

Family and domain databases

Gene3Di1.25.10.10, 2 hits
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR024660 UCS_central_dom
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
PF11701 UNC45-central, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48371 SSF48371, 3 hits
SSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q99KD5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVSGPETPE PRPSDPGASS AEQLRKEGNE LFKCGDYEGA LTAYTQALSL
60 70 80 90 100
GATPQDQAIL HRNRAACHLK LEDYSKAESE ASKAIEKDGG DVKALYRRSQ
110 120 130 140 150
ALEKLGRLDQ AVLDLKRCVS LEPKNKVFQE SLRNIGGQIQ EKVRYMSSTD
160 170 180 190 200
AKVEQMFQIL LDPKEKGTEK KQKASQNLVV LAREDAGAEK IFRSNGVQLL
210 220 230 240 250
QRLLDTEETD LMLAALRTLV GICSEHQSRT VATLSVLGTR RVVSILGVEN
260 270 280 290 300
QAVSLAACHL LQVIFDALKE GVKKGFRGKE GAIIVDPARE LKVLINSLLE
310 320 330 340 350
LLTEVGVSGQ GRDNALTLLI KMVPRKSPKD PNNSLTLWVI DQGLKKILEV
360 370 380 390 400
GGSLQDAAGE LTVTANSRMS ASILLSKLFD DLKCDAEREN FHRLCENYIR
410 420 430 440 450
NWFEGHGLAG KLRAIQTVSC LLQGPCDAGN RALELSGVME SVIALCASER
460 470 480 490 500
EEEQLVAVEA LIHAAGKAKR ASFITANGVS LLKDLYKGSE RDSIRIRALV
510 520 530 540 550
GLCKLGSAGG TDFSMKQFAE GSTLKLAKQC RKWLCNDQID AGTRRWAVEG
560 570 580 590 600
LAYLTFDADV KEEFVEDEAA LKALFQLSRS EERSVLFAVG SALVNCTNSY
610 620 630 640 650
DYEEPDPKMV ELAKYAKQHV PEQHPKDKPS FVRARVKKLL AAGVVSAMTC
660 670 680 690 700
MVKTESPVLT NSCRELLSRV FLALVEEVED RGTVVAQGGG KALLPLALEG
710 720 730 740 750
TDVGQTKAAQ ALAKLTITSN PEMTFPGERI YEVVRPLVSL LHLSCSGLQN
760 770 780 790 800
FEALMALTNL AGISERLRQK ILKEKAVPMI EGYMFEEHEM IRRAATECMC
810 820 830 840 850
NLAMSKEVQD LFEAQGNDRL KLLVLYSGED DELLRRAAAG GLAMLTSMRP
860 870 880 890 900
ALCSRIPQVT THWLEILQAL LLSPNQELQH RGTVVVLNMM QSSKEIAGTL
910 920 930 940
MESEVLEILS VLAKGEESPV TRAAAACLEK AVEYRLIQPN QDGE
Length:944
Mass (Da):103,447
Last modified:September 19, 2006 - v2
Checksum:i61E15C6DE421242D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIN1D6RIN1_MOUSE
Protein unc-45 homolog A
Unc45a
625Annotation score:
D3YZN8D3YZN8_MOUSE
Protein unc-45 homolog A
Unc45a
273Annotation score:
D3YVI2D3YVI2_MOUSE
Protein unc-45 homolog A
Unc45a
84Annotation score:
A0A0U1RNI4A0A0U1RNI4_MOUSE
Protein unc-45 homolog A
Unc45a
113Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86E → G in BAC26192 (PubMed:16141072).Curated1
Sequence conflicti401N → S in AAH04717 (PubMed:15489334).Curated1
Sequence conflicti492D → G in BAC33017 (PubMed:16141072).Curated1
Sequence conflicti492D → G in BAC33070 (PubMed:16141072).Curated1
Sequence conflicti851A → T in AAH04717 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028912 mRNA Translation: BAC26192.1
AK047292 mRNA Translation: BAC33017.1
AK047476 mRNA Translation: BAC33070.1
AK166809 mRNA Translation: BAE39037.1
BC004717 mRNA Translation: AAH04717.1
CCDSiCCDS21395.1
RefSeqiNP_598713.2, NM_133952.2
XP_011249076.1, XM_011250774.1
UniGeneiMm.243024

Genome annotation databases

EnsembliENSMUST00000032748; ENSMUSP00000032748; ENSMUSG00000030533
ENSMUST00000107368; ENSMUSP00000102991; ENSMUSG00000030533
GeneIDi101869
KEGGimmu:101869
UCSCiuc009iam.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028912 mRNA Translation: BAC26192.1
AK047292 mRNA Translation: BAC33017.1
AK047476 mRNA Translation: BAC33070.1
AK166809 mRNA Translation: BAE39037.1
BC004717 mRNA Translation: AAH04717.1
CCDSiCCDS21395.1
RefSeqiNP_598713.2, NM_133952.2
XP_011249076.1, XM_011250774.1
UniGeneiMm.243024

3D structure databases

ProteinModelPortaliQ99KD5
SMRiQ99KD5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221742, 1 interactor
STRINGi10090.ENSMUSP00000032748

PTM databases

iPTMnetiQ99KD5
PhosphoSitePlusiQ99KD5

Proteomic databases

EPDiQ99KD5
MaxQBiQ99KD5
PaxDbiQ99KD5
PeptideAtlasiQ99KD5
PRIDEiQ99KD5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032748; ENSMUSP00000032748; ENSMUSG00000030533
ENSMUST00000107368; ENSMUSP00000102991; ENSMUSG00000030533
GeneIDi101869
KEGGimmu:101869
UCSCiuc009iam.3 mouse

Organism-specific databases

CTDi55898
MGIiMGI:2142246 Unc45a

Phylogenomic databases

eggNOGiKOG4151 Eukaryota
ENOG410XQNT LUCA
GeneTreeiENSGT00900000140844
HOGENOMiHOG000285994
HOVERGENiHBG057344
InParanoidiQ99KD5
KOiK21991
OMAiDQGLKKI
OrthoDBiEOG091G02FM
PhylomeDBiQ99KD5
TreeFamiTF314096

Miscellaneous databases

PROiPR:Q99KD5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030533 Expressed in 300 organ(s), highest expression level in limb
CleanExiMM_SMAP1
MM_UNC45A
ExpressionAtlasiQ99KD5 baseline and differential
GenevisibleiQ99KD5 MM

Family and domain databases

Gene3Di1.25.10.10, 2 hits
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR024660 UCS_central_dom
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
PF11701 UNC45-central, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48371 SSF48371, 3 hits
SSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUN45A_MOUSE
AccessioniPrimary (citable) accession number: Q99KD5
Secondary accession number(s): Q3TKV6, Q8BFT3, Q8C157
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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