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Protein

von Willebrand factor A domain-containing protein 5A

Gene

Vwa5a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in may contribute directly to or modify tumorigenesis (By similarity).By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor A domain-containing protein 5A
Alternative name(s):
Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog
Gene namesi
Name:Vwa5a
Synonyms:Loh11cr2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1915026 Vwa5a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844121 – 793von Willebrand factor A domain-containing protein 5AAdd BLAST793

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei622PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99KC8
MaxQBiQ99KC8
PaxDbiQ99KC8
PeptideAtlasiQ99KC8
PRIDEiQ99KC8

PTM databases

iPTMnetiQ99KC8
PhosphoSitePlusiQ99KC8
SwissPalmiQ99KC8

Expressioni

Gene expression databases

BgeeiENSMUSG00000023186 Expressed in 268 organ(s), highest expression level in dorsal root ganglion
ExpressionAtlasiQ99KC8 baseline and differential
GenevisibleiQ99KC8 MM

Interactioni

Protein-protein interaction databases

BioGridi212436, 1 interactor
IntActiQ99KC8, 1 interactor
MINTiQ99KC8
STRINGi10090.ENSMUSP00000001544

Structurei

3D structure databases

ProteinModelPortaliQ99KC8
SMRiQ99KC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 131VITPROSITE-ProRule annotationAdd BLAST131
Domaini281 – 469VWFAPROSITE-ProRule annotationAdd BLAST189

Phylogenomic databases

eggNOGiENOG410IG85 Eukaryota
COG2304 LUCA
GeneTreeiENSGT00530000063006
InParanoidiQ99KC8
OMAiFNVIRFD
OrthoDBiEOG091G03Q4
PhylomeDBiQ99KC8
TreeFamiTF329720

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF08487 VIT, 1 hit
PF13768 VWA_3, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99KC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHHCGLITS NKETVPLKNI SVTLSINEFV AAVVATLNYE NEEKVPLEAT
60 70 80 90 100
FVFPMDEDSA VYSFEALVDG KKIVAELQDK MKAHSEYEEA LSQGHQAYLL
110 120 130 140 150
EEDDYSRDVF SCNVGNLQPG AKVAVTLRYV QELPLETDGA LRYLLPAILN
160 170 180 190 200
PRYQLSEQSA NSCLNIQKPT VPLEDLPYTL NMTATITSQH GIERVQSNCS
210 220 230 240 250
LSPIQYLTDD KTSAQVSLTE GHKFDRDVEL LIYYNEVHSP SVAVEMGMLD
260 270 280 290 300
MKPDSLMGAP SAMVSFYPDI PEVEASKACG EFVFLMDRSG SMDSPMSTEN
310 320 330 340 350
NSQLRIEAAK ETLLLLLKSL PMGCYFNIYG FGSSYEKFFP ESVKYTQDTM
360 370 380 390 400
EDAVKRVKAL KANLGGTEIL TPLCNIYKAS SIPGHPLQLF VFTDGEVSDT
410 420 430 440 450
FSVIREVKLN SKKHRCFSFG IGQGASTSLI KNIARVSGGT AVFITGKDRM
460 470 480 490 500
QTKALGSLKF ALQCAVDNIS LSWDLPPGLS VKMLSPEQLT IFRGQRLIIY
510 520 530 540 550
AQLTGLMPQV ESTGAVCLKH ILQGRSLENR VTFSLQPKAN DNFTIHRLAA
560 570 580 590 600
KSLIQTKDFG SQEASKEEKE DVMNISLQSG VLSSFTAFIA INKELNKPVQ
610 620 630 640 650
GPLAHRVIPR PVMAGSSSMR FYSSFSGGFK GPQPRSLRVP AYDLCSAESA
660 670 680 690 700
NLVLKKSACS AIQKKKTNSS TNKSNLKKEH KAFGENAVVQ LISLQKANGS
710 720 730 740 750
WELDEDLTKI LGTKSKDIKA ANPAKHEDPS AWSTVLAVVW LHANGTDLKC
760 770 780 790
EWELLERKAV AWLHDHAGSS IPMLVQAANS LLKLSVNPAV FGV
Length:793
Mass (Da):87,143
Last modified:April 12, 2005 - v2
Checksum:i3A9FD99F03C600AC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z671D3Z671_MOUSE
von Willebrand factor A domain-cont...
Vwa5a
38Annotation score:
F6TIL5F6TIL5_MOUSE
von Willebrand factor A domain-cont...
Vwa5a
137Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152R → G in BAB31913 (PubMed:16141072).Curated1
Sequence conflicti172P → T in BAE23178 (PubMed:16141072).Curated1
Sequence conflicti179T → I in AAQ94870 (PubMed:14504409).Curated1
Sequence conflicti347Q → R in BAE20590 (PubMed:16141072).Curated1
Sequence conflicti733S → A in AAH04727 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY366502 mRNA Translation: AAQ94870.1
AK019914 mRNA Translation: BAB31913.3
AK041397 mRNA Translation: BAE20590.1
AK053665 mRNA Translation: BAC35467.1
AK054497 mRNA Translation: BAC35804.1
AK136934 mRNA Translation: BAE23178.1
AK161193 mRNA Translation: BAE36232.1
BC004727 mRNA Translation: AAH04727.1
BC065153 mRNA Translation: AAH65153.1
CCDSiCCDS23024.1
RefSeqiNP_001139429.1, NM_001145957.1
NP_766355.3, NM_172767.3
UniGeneiMm.290950

Genome annotation databases

EnsembliENSMUST00000001544; ENSMUSP00000001544; ENSMUSG00000023186
ENSMUST00000118144; ENSMUSP00000113596; ENSMUSG00000023186
GeneIDi67776
KEGGimmu:67776
UCSCiuc009oxa.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY366502 mRNA Translation: AAQ94870.1
AK019914 mRNA Translation: BAB31913.3
AK041397 mRNA Translation: BAE20590.1
AK053665 mRNA Translation: BAC35467.1
AK054497 mRNA Translation: BAC35804.1
AK136934 mRNA Translation: BAE23178.1
AK161193 mRNA Translation: BAE36232.1
BC004727 mRNA Translation: AAH04727.1
BC065153 mRNA Translation: AAH65153.1
CCDSiCCDS23024.1
RefSeqiNP_001139429.1, NM_001145957.1
NP_766355.3, NM_172767.3
UniGeneiMm.290950

3D structure databases

ProteinModelPortaliQ99KC8
SMRiQ99KC8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212436, 1 interactor
IntActiQ99KC8, 1 interactor
MINTiQ99KC8
STRINGi10090.ENSMUSP00000001544

PTM databases

iPTMnetiQ99KC8
PhosphoSitePlusiQ99KC8
SwissPalmiQ99KC8

Proteomic databases

EPDiQ99KC8
MaxQBiQ99KC8
PaxDbiQ99KC8
PeptideAtlasiQ99KC8
PRIDEiQ99KC8

Protocols and materials databases

DNASUi67776
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001544; ENSMUSP00000001544; ENSMUSG00000023186
ENSMUST00000118144; ENSMUSP00000113596; ENSMUSG00000023186
GeneIDi67776
KEGGimmu:67776
UCSCiuc009oxa.2 mouse

Organism-specific databases

CTDi4013
MGIiMGI:1915026 Vwa5a

Phylogenomic databases

eggNOGiENOG410IG85 Eukaryota
COG2304 LUCA
GeneTreeiENSGT00530000063006
InParanoidiQ99KC8
OMAiFNVIRFD
OrthoDBiEOG091G03Q4
PhylomeDBiQ99KC8
TreeFamiTF329720

Miscellaneous databases

PROiPR:Q99KC8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023186 Expressed in 268 organ(s), highest expression level in dorsal root ganglion
ExpressionAtlasiQ99KC8 baseline and differential
GenevisibleiQ99KC8 MM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF08487 VIT, 1 hit
PF13768 VWA_3, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVMA5A_MOUSE
AccessioniPrimary (citable) accession number: Q99KC8
Secondary accession number(s): Q3TTU2
, Q3UVU1, Q3V3F2, Q6UN22, Q8BHA8, Q9CTV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: April 12, 2005
Last modified: November 7, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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