Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Gene

Tab2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187' (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri663 – 693RanBP2-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-168638 NOD1/2 Signaling Pathway
R-MMU-202424 Downstream TCR signaling
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-450302 activated TAK1 mediates p38 MAPK activation
R-MMU-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-MMU-5357956 TNFR1-induced NFkappaB signaling pathway
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-9020702 Interleukin-1 signaling
R-MMU-937042 IRAK2 mediated activation of TAK1 complex
R-MMU-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-MMU-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
TAK1-binding protein 2
Short name:
TAB-2
TGF-beta-activated kinase 1-binding protein 2
Gene namesi
Name:Tab2
Synonyms:Kiaa0733, Map3k7ip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1915902 Tab2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi674T → A: Loss of interaction with 'Lys-63'-linked ubiquitin. 1 Publication1
Mutagenesisi675F → A: Loss of interaction with 'Lys-63'-linked ubiquitin. 1 Publication1
Mutagenesisi678H → Q: Loss of interaction with 'Lys-63'-linked ubiquitin. 1 Publication1
Mutagenesisi681L → T: Loss of interaction with 'Lys-63'-linked ubiquitin. 1 Publication1
Mutagenesisi685E → V: Loss of interaction with 'Lys-63'-linked ubiquitin. 1 Publication1
Mutagenesisi686Q → I or M: Confers ability to bind monoubiquitin and polyubiquitin, irrespective of the type of linkage. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256961 – 693TGF-beta-activated kinase 1 and MAP3K7-binding protein 2Add BLAST693

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173Asymmetric dimethylarginineCombined sources1
Modified residuei372PhosphoserineBy similarity1
Modified residuei450PhosphoserineBy similarity1
Modified residuei482PhosphoserineBy similarity1
Modified residuei524PhosphoserineCombined sources1
Modified residuei582PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to7 proteasomal degradation (By similarity).By similarity
Phosphorylated.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99K90
MaxQBiQ99K90
PaxDbiQ99K90
PRIDEiQ99K90

PTM databases

iPTMnetiQ99K90
PhosphoSitePlusiQ99K90

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000015755 Expressed in 311 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiQ99K90 baseline and differential
GenevisibleiQ99K90 MM

Interactioni

Subunit structurei

Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1 (By similarity). Interacts with TRIM5 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212973, 9 interactors
IntActiQ99K90, 4 interactors
MINTiQ99K90
STRINGi10090.ENSMUSP00000121266

Structurei

Secondary structure

1693
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99K90
SMRiQ99K90
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99K90

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 51CUEPROSITE-ProRule annotationAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni675 – 685Interaction with polyubiquitinAdd BLAST11

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili532 – 619Sequence analysisAdd BLAST88

Domaini

The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri663 – 693RanBP2-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IK8E Eukaryota
ENOG410XPAC LUCA
GeneTreeiENSGT00530000063642
HOGENOMiHOG000261646
HOVERGENiHBG056952
InParanoidiQ99K90
KOiK04404
OMAiREGNRMN
OrthoDBiEOG091G0AYA
PhylomeDBiQ99K90
TreeFamiTF332021

Family and domain databases

InterProiView protein in InterPro
IPR003892 CUE
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PfamiView protein in Pfam
PF02845 CUE, 1 hit
SMARTiView protein in SMART
SM00546 CUE, 1 hit
SM00547 ZnF_RBZ, 1 hit
SUPFAMiSSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99K90-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQGSHQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSQES
60 70 80 90 100
TRYLYGEGDL NFSDESGISG LRNHMTSLNL DLQSQNVYHH GREGSRVNGS
110 120 130 140 150
RTLTHSVSDG QLHGGQSNNE LFQQEPQTAP AQVPQGFNVF GMPSTSGASN
160 170 180 190 200
STPHLGFHLG SKGTSNLSQQ TPRFNPIMVT LAPNIQTGRS TPTSLHIHGV
210 220 230 240 250
PPPVLNSPQG NSIYIRPYIT TPSGTARQTQ QHSGWVSQFN PMNPQQAYQP
260 270 280 290 300
SQPGPWTTYP ASNPLPHTST QQPNQQGHQT SHVYMPISSP TTPQPPTIHS
310 320 330 340 350
SGSSQSSAHS QYNIQNISTG PRKNQIEIKL EPPQRNSSSK LRSSGPRTAS
360 370 380 390 400
TSSLVNSQTL NRNQPTVYIA ASPPNTDEMI SRSQPKVYIS ANATAGDEQG
410 420 430 440 450
MRNQPTLFIS TNSGPSAASR NMSGQVSMGP AFIHHHPPKS RVLGGNSATS
460 470 480 490 500
PRVVVTQPNT KYTFKITVSP NKPPAVSPGV VSPTFELTNL LNHPDHYVET
510 520 530 540 550
ENIQHLTDPA LAHVDRISEA RKLSMGSDDA AYTQALLVHQ KARMERLQRE
560 570 580 590 600
LEMQKKKLDK LKSEVNEMEN NLTRRRLKRS NSISQIPSLE EMQQLRSCNR
610 620 630 640 650
QLQIDIDCLT KEIDLFQARG PHFNPSAIHN FYDNIGFVGP VPPKPKDQRS
660 670 680 690
TIKAPKTQDA EDEEGAQWNC TACTFLNHPA LIRCEQCEMP RHF
Length:693
Mass (Da):76,442
Last modified:June 1, 2001 - v1
Checksum:i810F17CBE6F80BA8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z216D3Z216_MOUSE
TGF-beta-activated kinase 1 and MAP...
Tab2
553Annotation score:
D3Z564D3Z564_MOUSE
TGF-beta-activated kinase 1 and MAP...
Tab2
385Annotation score:

Sequence cautioni

The sequence BAC40772 differs from that shown. Reason: Frameshift at positions 62, 72, 152 and 275.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183P → T in BAE28166 (PubMed:16141072).Curated1
Sequence conflicti476V → F in BAC40772 (PubMed:16141072).Curated1
Sequence conflicti580S → L in BAE28166 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093701 mRNA Translation: AAM10487.1
BC004072 mRNA Translation: AAH04072.1
BC004813 mRNA Translation: AAH04813.1
AK089164 mRNA Translation: BAC40772.1 Frameshift.
AK147830 mRNA Translation: BAE28166.1
AB093262 mRNA Translation: BAC41446.1
CCDSiCCDS23691.1
RefSeqiNP_619608.1, NM_138667.3
XP_017169562.1, XM_017314073.1
UniGeneiMm.193041
Mm.395107

Genome annotation databases

EnsembliENSMUST00000146444; ENSMUSP00000121266; ENSMUSG00000015755
GeneIDi68652
KEGGimmu:68652
UCSCiuc007eir.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093701 mRNA Translation: AAM10487.1
BC004072 mRNA Translation: AAH04072.1
BC004813 mRNA Translation: AAH04813.1
AK089164 mRNA Translation: BAC40772.1 Frameshift.
AK147830 mRNA Translation: BAE28166.1
AB093262 mRNA Translation: BAC41446.1
CCDSiCCDS23691.1
RefSeqiNP_619608.1, NM_138667.3
XP_017169562.1, XM_017314073.1
UniGeneiMm.193041
Mm.395107

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A9JX-ray1.18C665-693[»]
ProteinModelPortaliQ99K90
SMRiQ99K90
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212973, 9 interactors
IntActiQ99K90, 4 interactors
MINTiQ99K90
STRINGi10090.ENSMUSP00000121266

PTM databases

iPTMnetiQ99K90
PhosphoSitePlusiQ99K90

Proteomic databases

EPDiQ99K90
MaxQBiQ99K90
PaxDbiQ99K90
PRIDEiQ99K90

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000146444; ENSMUSP00000121266; ENSMUSG00000015755
GeneIDi68652
KEGGimmu:68652
UCSCiuc007eir.2 mouse

Organism-specific databases

CTDi23118
MGIiMGI:1915902 Tab2
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IK8E Eukaryota
ENOG410XPAC LUCA
GeneTreeiENSGT00530000063642
HOGENOMiHOG000261646
HOVERGENiHBG056952
InParanoidiQ99K90
KOiK04404
OMAiREGNRMN
OrthoDBiEOG091G0AYA
PhylomeDBiQ99K90
TreeFamiTF332021

Enzyme and pathway databases

ReactomeiR-MMU-168638 NOD1/2 Signaling Pathway
R-MMU-202424 Downstream TCR signaling
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-450302 activated TAK1 mediates p38 MAPK activation
R-MMU-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-MMU-5357956 TNFR1-induced NFkappaB signaling pathway
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-9020702 Interleukin-1 signaling
R-MMU-937042 IRAK2 mediated activation of TAK1 complex
R-MMU-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-MMU-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Miscellaneous databases

ChiTaRSiTab2 mouse
EvolutionaryTraceiQ99K90
PROiPR:Q99K90
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015755 Expressed in 311 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiQ99K90 baseline and differential
GenevisibleiQ99K90 MM

Family and domain databases

InterProiView protein in InterPro
IPR003892 CUE
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PfamiView protein in Pfam
PF02845 CUE, 1 hit
SMARTiView protein in SMART
SM00546 CUE, 1 hit
SM00547 ZnF_RBZ, 1 hit
SUPFAMiSSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAB2_MOUSE
AccessioniPrimary (citable) accession number: Q99K90
Secondary accession number(s): Q3UGP1
, Q8BTP4, Q8CHD3, Q99KP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again